PDBsum entry 2zn7

Hydrolase

PDB id: 2zn7

Contents

Protein chain

297 a.a. *

Ligands

410

Waters ×218

* Residue conservation analysis

PDB id:

2zn7

Name:

Hydrolase

Title:

Crystal structures of ptp1b-inhibitor complexes

Structure:

Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: catalytic domain, residues 1-299. Synonym: protein-tyrosine phosphatase 1b, ptp-1b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptp1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.10Å R-factor: 0.179 R-free: 0.206

Authors:

W.Xu,J.Wu

Key ref:

Z.K.Wan et al. (2008). Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24. Chemmedchem, 3, 1525-1529. PubMed id: 18798205

Date:

22-Apr-08 Release date: 07-Oct-08

Protein chain

P18031  (PTN1_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 1 from Homo sapiens

Seq: 435 a.a.

Struc: 297 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

Chemmedchem 3:1525-1529 (2008)

PubMed id: 18798205

Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.

Z.K.Wan, J.Lee, R.Hotchandani, A.Moretto, E.Binnun, D.P.Wilson, S.J.Kirincich, B.C.Follows, M.Ipek, W.Xu, D.Joseph-McCarthy, Y.L.Zhang, M.Tam, D.V.Erbe, J.F.Tobin, W.Li, S.Y.Tam, T.S.Mansour, J.Wu.

ABSTRACT

No abstract given.