PDBsum entry 2vph

Hydrolase

PDB id: 2vph

Contents

Protein chains

98 a.a. *

92 a.a. *

Waters ×72

* Residue conservation analysis

PDB id:

2vph

Name:

Hydrolase

Title:

Crystal structure of the human protein tyrosine phosphatase, non- receptor type 4, pdz domain

Structure:

Tyrosine-protein phosphatase non-receptor type 4. Chain: a, b. Fragment: pdz domain, residues 513-606. Synonym: protein-tyrosine phosphatase meg1, ptpase-meg1, meg. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-rosetta-prare2.

Resolution:

1.90Å R-factor: 0.210 R-free: 0.243

Authors:

A.K.Roos,J.Wang,N.Burgess-Brown,J.M.Elkins,K.Kavanagh,A.C.W.Pike, P.Filippakopoulos,C.H.Arrowsmith,J.Weigelt,A.Edwards,F.Von Delft, C.Bountra,S.Knapp

Key ref:

A.K.Roos et al. Crystal structure of the human protein tyrosine phosphatase, Non-Receptor type 4, Pdz domain. To be published, .

Date:

29-Feb-08 Release date: 18-Mar-08

Protein chain

P29074  (PTN4_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 4 from Homo sapiens

Seq: 926 a.a.

Struc: 98 a.a.*

Protein chain

P29074  (PTN4_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 4 from Homo sapiens

Seq: 926 a.a.

Struc: 92 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site