PDBsum entry 2pl2

Protein binding

PDB id

2pl2

Loading ...

Contents

			Protein chains

					194 a.a. *

			Waters ×56

* Residue conservation analysis

PDB id:

2pl2

Links

Name:

Protein binding

Title:

Crystal structure of ttc0263: a thermophilic tpr protein in thermus thermophilus hb27

Structure:

Hypothetical conserved protein ttc0263. Chain: a, b. Fragment: residues 25-241. Engineered: yes

Source:

Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.50Å

R-factor:

0.236

Authors:

H.Lim,K.Kim,D.Han,J.Oh

Key ref:

H.Lim et al. (2007). Crystal structure of TTC0263, a thermophilic TPR protein from Thermus thermophilus HB27. Mol Cells, 24, 27-36. PubMed id: 17846496

Date:

18-Apr-07

Release date:

04-Mar-08

PROCHECK

	Headers

	References

Protein chains

Q72L02 (Q72L02_THET2) - Hypothetical conserved protein from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)

Seq: Struc:					355 a.a. 194 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Mol Cells 24:27-36 (2007)
PubMed id: 17846496

Crystal structure of TTC0263, a thermophilic TPR protein from Thermus thermophilus HB27.
H.Lim, K.Kim, D.Han, J.Oh, Y.Kim.

ABSTRACT

The hypothetical protein TTC0263 of Thermus thermophilus HB27 is a thermophilic tetratricopeptide repeat (TPR)-containing protein. In the present study, the TPR region (residues 26-230) was resolved at 2.5 A with R-factors of R/Rfree = 23.6%/28.6%. TTC0263 consists of 11 helices that form five TPR units. Uniquely, it contains one atypical "extended" TPR (eTPR) unit. This comprises extended helical residues near the loop region of TTC0263, such that the helical length of eTPR is longer than that of the canonical TPR sequence. In addition, the hybrid TPR domain of TTC0263 possesses oligomer-forming characteristics. TPR domains are generally involved in forming multi-subunit complexes by interacting with each other or with other subunit proteins. The dynamic structure of TTC0263 described here goes some way to explaining how TPR domains mediate the formation of multi-subunit complexes.

Literature references that cite this PDB file's key reference

PubMed id

Reference

18606795

S.Park, and R.L.Ely (2008).
Candidate stress genes of Nitrosomonas europaea for monitoring inhibition of nitrification by heavy metals.

Appl Environ Microbiol, 74, 5475-5482.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.