PDBsum entry 2p33

Transferase

PDB id: 2p33

Contents

Protein chain

332 a.a.

Ligands

J07

Waters ×44

References listed in PDB file

Key reference

• Title: Synthesis and sar of aminopyrimidines as novel c-Jun n-Terminal kinase (jnk) inhibitors.
• Authors: M.Alam, R.E.Beevers, T.Ceska, R.J.Davenport, K.M.Dickson, M.Fortunato, L.Gowers, A.F.Haughan, L.A.James, M.W.Jones, N.Kinsella, C.Lowe, J.W.Meissner, A.L.Nicolas, B.G.Perry, D.J.Phillips, W.R.Pitt, A.Platt, A.J.Ratcliffe, A.Sharpe, L.J.Tait.
• Ref.: Bioorg Med Chem Lett, 2007, 17, 3463-3467. [DOI no: 10.1016/j.bmcl.2007.03.078]
• PubMed id: 17459703

Abstract

The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.