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PDBsum entry 2lv9
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PDB id:
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Transferase
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Title:
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Solution nmr structure of the phd domain of human mll5, northeast structural genomics consortium target hr6512a
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Structure:
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Histone-lysine n-methyltransferase mll5. Chain: a. Fragment: phd-type domain residues 109-188. Synonym: lysine n-methyltransferase 2e, kmt2e, myeloid/lymphoid or mixed-lineage leukemia protein 5. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mll5, kmt2e. Expressed in: escherichia coli. Expression_system_taxid: 562.
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NMR struc:
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20 models
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Authors:
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A.Lemak,A.Yee,S.Houliston,M.Garcia,H.Wu,J.Min,G.T.Montelione, C.Arrowsmith,Northeast Structural Genomics Consortium (Nesg), Structural Genomics Consortium (Sgc),Chaperone-Enabled Studies Of Epigenetic Regulation Enzymes (Cebs)
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Key ref:
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A.Lemak
et al.
Nmr solution structure of the human mll5 phd domain ( target).
To be published,
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Date:
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29-Jun-12
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Release date:
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05-Sep-12
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PROCHECK
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Headers
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References
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Q8IZD2
(KMT2E_HUMAN) -
Inactive histone-lysine N-methyltransferase 2E from Homo sapiens
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Seq:
Struc:
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1858 a.a.
80 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.43
- Transferred entry: 2.1.1.354.
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Reaction:
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S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone]
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S-adenosyl-L-methionine
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+
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L-lysine-[histone]
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=
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S-adenosyl-L-homocysteine
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+
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N(6)-methyl-L-lysine-[histone]
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
