_EC 2.1.1.43 Histone-lysine N-methyltransferase. 154 PDB entries  
EC 2.-.-.- Transferases. [17,772 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,717 PDB entries]
EC 2.1.1.- Methyltransferases. [1,369 PDB entries]
EC 2.1.1.43 Histone-lysine N-methyltransferase. [154 PDB entries]    
1e0n

Reaction: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
 


S-adenosyl-L-methionine
+ L-lysine-[histone]
=
S-adenosyl-L-homocysteine
+ N(6)-methyl-L-lysine-[histone]
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Protein methylase 3. Protein methylase Iii. Protein methyltransferase Ii. Protein-lysine N-methyltransferase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 154 PDB entries in enzyme class E.C.2.1.1.43

  PDB code Protein
1e0n
Yjq8ww domain from saccharomyces cerevisae
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (27 residues)
1g6z
Solution structure of the clr4 chromo domain
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: clr4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (70 residues) CATH domain: 2.40.50.40
1h3i
Crystal structure of the histone methyltransferase set7/9
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (293 residues) CATH domains: 2.20.110.10 2.170.270.10
1ml9
Structure of the neurospora set domain protein dim-5, a histone lysine methyltransferase
Source: Neurospora crassa. Organism_taxid: 5141. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (260 residues) CATH domain: 2.170.270.10
1mt6
Structure of histone h3 k4-specific methyltransferase set7/9 with adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (280 residues) CATH domains: 2.20.110.10 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1muf
Structure of histone h3 k4-specific methyltransferase set7/9
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (257 residues) CATH domains: Unassigned 2.170.270.10
1mvh
Structure of the set domain histone lysine methyltransferase clr4
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domain: 2.170.270.10
1mvx
Structure of the set domain histone lysine methyltransferase clr4
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domain: 2.170.270.10
1n6a
Structure of set7/9
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (234 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1n6c
Structure of set7/9
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (283 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1nw3
Structure of the catalytic domain of human dot1l, a non-set nucleosomal histone methyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (328 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1o9s
Crystal structure of a ternary complex of the human histone methyltransferase set7/9
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, B (250 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH is 96.00% similar to enzyme product S-adenosylhomocysteine
1peg
Structural basis for the product specificity of histone lysine methyltransferases
Source: Neurospora crassa. Organism_taxid: 5141. Expressed in: escherichia coli. Expression_system_taxid: 562. (Stratagene). Synthetic: yes. Other_details: the histone h3 peptide (n-terminal residues 1-15) is synthesized.
Chains: A, B (266 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1u2z
Crystal structure of histone k79 methyltransferase dot1p from yeast
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: dot1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (379 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1xqh
Crystal structure of a ternary complex of the methyltransferase set9 (also known as set7/9) with a p53 peptide and sah
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in humans.
Chains: A, E (250 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1zkk
Crystal structure of hset8 in ternary complex with h4 peptide (16-24) and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: set8, prset7, set07. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chain e, f, g, h are synthetic peptide from new england peptide corresponding to residue 15-24 of the
Chains: A, B, C, D (160 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2a7o
Solution structure of the hset2/hypb sri domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hset2/hypb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (100 residues)
2agh
Structural basis for cooperative transcription factor binding to the cbp coactivator
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: myb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: cbp, crebbp. Homo sapiens. Human.
Chain: C (31 residues)
2bqz
Crystal structure of a ternary complex of the human histone methyltransferase pr-set7 (also known as set8)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, E (161 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH is 96.00% similar to enzyme product S-adenosylhomocysteine
2c5z
Structure and ctd binding of the set2 sri domain
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (93 residues)
2daq
Solution structure of second pwwp domain of whsc1l1 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: whsc1l1. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (110 residues) CATH domain: 2.30.30.160
2f69
Ternary complex of set7/9 bound to adohcy and a taf10 peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: set7, kiaa1717. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Other_details: synthetic human taf10 peptide
Chain: A (244 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2igq
Human euchromatic histone methyltransferase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (251 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2j2s
Solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone methyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (72 residues) CATH domain: Unassigned
2j8a
X-ray structure of the n-terminus rrm domain of set1
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: s228c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (114 residues) CATH domain: 3.30.70.330
2jv0
Set domain of riz1 tumor suppressor (prdm2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prdm2, riz. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (163 residues) CATH domain: 2.170.270.10
2jyi
Solution structure of mll cxxc domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll, all1, hrx, htrx, trx1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (57 residues) CATH domain: Unassigned
2kkf
Solution structure of mll cxxc domain in complex with palindromic cpg DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: all1, cxxc7, hrx, htrx, kmt2a, mll, trx1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: palindromic DNA
Chain: A (57 residues) CATH domain: Unassigned
2ku7
Solution structure of mll1 phd3-cyp33 rrm chimeric protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (140 residues) CATH domain: Unassigned
2kyu
The solution structure of the phd3 finger of mll
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll, all1, cxxc7, hrx, htrx, kmt2a, mll1, trx1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (67 residues) CATH domain: 3.30.40.10
2l7p
Ashh2 a cw domain
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: ashh2, efs, sdg8, set8, at1g77300, t14n5.15. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (100 residues) CATH domain: Unassigned
2lv9
Solution nmr structure of the phd domain of human mll5, nort structural genomics consortium target hr6512a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll5, kmt2e. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (80 residues) CATH domain: Unassigned
2lxe
S4wyild
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: suvr4, sdg31, set31, at3g04380, t27c4.2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (109 residues) CATH domain: Unassigned
2lxs
Allosteric communication in the kix domain proceeds through re-packing of the hydrophobic core
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: crebbp, cbp. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mll, all1, cxxc7, hrx, htrx, kmt2a, mll1, trx1.
Chain: B (19 residues)
2lxt
Allosteric communication in the kix domain proceeds through re-packing of the hydrophobic core
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: crebbp, cbp. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mll, all1, cxxc7, hrx, htrx, kmt2a, mll1, trx1. Gene: creb1.
Chain: B (19 residues)
2msr
Solution structure of ledgf/p75 ibd in complex with mll1 pep 160)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kmt2a, all1, cxxc7, hrx, htrx, mll, mll1, trx1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: psip1, dfs70, ledgf, psip2.
Chain: A (21 residues)
2o8j
Human euchromatic histone methyltransferase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt2, bat8, g9a, ng36. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (254 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2qpw
Methyltransferase domain of human pr domain-containing protein 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prdm2, riz. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (147 residues) CATH domain: 2.170.270.10
2qxv
Structural basis of ezh2 recognition by eed
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: heed. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: ezh2, enx1h.
Chain: B (29 residues)
2r3a
Methyltransferase domain of human suppressor of variegation 3-9 homolog 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: suv39h2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (270 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
2rfi
Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic dimethylated h3k9 peptide
Chains: A, B (261 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2w5y
Binary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chain: A (170 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2w5z
Ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chain: A (180 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2ysm
Solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll3, halr, kiaa1506. Other_details: cell-free protein synthesis
Chain: A (111 residues) CATH domain: Unassigned
2yuk
Solution structure of the hmg box of human myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll3. Other_details: cell-free protein synthesis
Chain: A (90 residues) CATH domain: Unassigned
3b7b
Euhmt1 (glp) ankyrin repeat domain (structure 1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (236 residues) CATH domain: 1.25.40.20
3b95
Euhmt1 (glp) ankyrin repeat domain (structure 2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (236 residues) CATH domain: 1.25.40.20
3bo5
Crystal structure of methyltransferase domain of human histo n-methyltransferase setmar
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setmar. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3cbm
Set7/9-er-adomet complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: er peptide
Chain: A (243 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3cbo
Set7/9-er-adohcy complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: er peptide
Chain: A (239 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3cbp
Set7/9-er-sinefungin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: er peptide
Chain: A (239 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SFG is 51.43% similar to enzyme product S-adenosylhomocysteine
3dlm
Crystal structure of tudor domain of human histone-lysine n- methyltransferase setdb1
Source: Homo sapiens. Organism_taxid: 9606. Gene: setdb1, kiaa0067, kmt1e. Expressed in: escherichia coli.
Chain: A (208 residues) CATH domains: Unassigned Unassigned Unassigned
3f2k
Structure of the transposase domain of human histone-lysine n-methyltransferase setmar
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setmar. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (197 residues) CATH domain: Unassigned
3f9w
Structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20 / adohcy
Source: Homo sapiens. Organism_taxid: 9606. Gene: setd8, kmt5a, prset7, set07, set8. Expressed in: escherichia coli. Synthetic: yes. Other_details: synthetic peptide corresponding to residues 16-25 of human histone h4
Chains: A, B, C, D (160 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3f9x
Structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me2 / adohcy
Source: Homo sapiens. Organism_taxid: 9606. Gene: setd8, kmt5a, prset7, set07, set8. Expressed in: escherichia coli. Synthetic: yes. Other_details: synthetic peptide corresponding to residues 16-25 of human histone h4
Chains: A, B, C, D (160 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3f9y
Structural insights into lysine multiple methylation by set methyltransferases, set8-y334f / h4-lys20me1 / adohcy
Source: Homo sapiens. Organism_taxid: 9606. Gene: setd8, kmt5a, prset7, set07, set8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide corresponding to residues human histone h4
Chains: A, B (159 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3f9z
Structural insights into lysine multiple methylation by set domain methyltransferases, set8-y245f / h4-lys20 / adohcy
Source: Homo sapiens. Organism_taxid: 9606. Gene: setd8, kmt5a, prset7, set07, set8. Expressed in: escherichia coli. Synthetic: yes. Other_details: synthetic peptide corresponding to residues 16-25 of human histone h4
Chains: A, B, C, D (156 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3fpd
G9a-like protein lysine methyltransferase inhibition by bix- 01294
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (261 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3h6l
Methyltransferase domain of human set domain-containing prot
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd2, hif1, hypb, kiaa1732, kmt3a, set2, hspc069. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (231 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3hna
Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono- methylated h3k9 peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Gene: ehmt1, euhmtase1, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (280 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3k5k
Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a po inhibitor of histone lysine methyltransferase, g9a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt2, bat8, c6orf30, g9a, kmt1c, ng36. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (272 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3k9j
Transposase domain of metnase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setmar. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (201 residues) CATH domain: Unassigned
3k9k
Transposase domain of metnase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setmar. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (211 residues) CATH domain: Unassigned
3lqh
Crystal structure of mll1 phd3-bromo in the free form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll, all1, cxxc7, hrx, htrx, kmt2a, mll1, trx1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (174 residues) CATH domains: Unassigned 1.20.920.10
3lqi
Crystal structure of mll1 phd3-bromo complexed with h3(1-9)k peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans.
Chains: A, B, C (176 residues) CATH domains: Unassigned 1.20.920.10
3lqj
Crystal structure of mll1 phd3-bromo complexed with h3(1-9)k peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans.
Chains: A, B (177 residues) CATH domains: Unassigned 1.20.920.10
3m53
Set7/9 in complex with taf10 peptide and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (246 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m54
Set7/9 y305f in complex with taf10 peptide and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (245 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m55
Set7/9 y305f in complex with taf10-k189me1 peptide and adohc
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (244 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m56
Set7/9 y305f in complex with taf10-k189me2 peptide and adohc
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (244 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m57
Set7/9 y245a in complex with taf10 peptide and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (244 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m58
Set7/9 y245a in complex with taf10-k189me1 peptide and adohc
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (253 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m59
Set7/9 y245a in complex with taf10-k189me2 peptide and adohc
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (245 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3m5a
Set7/9 y245a in complex with taf10-k189me3 peptide and adohc
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: kiaa1717, kmt7, set7, set9, setd7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (246 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3mek
Crystal structure of human histone-lysine n- methyltransferase smyd3 in complex with s-adenosyl-l- methionine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (423 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3mo0
Human g9a-like (glp, also known as ehmt1) in complex with in e11
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (251 residues) CATH domain: 2.170.270.10
3mo2
Human g9a-like (glp, also known as ehmt1) in complex with in e67
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (255 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3mo5
Human g9a-like (glp, also known as ehmt1) in complex with in e72
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (255 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3mqm
Crystal structure of the bromodomain of human ash1l
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ash1l, kiaa1420, kmt2h. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (126 residues) CATH domain: 1.20.920.10
3mts
Chromo domain of human histone-lysine n-methyltransferase su
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kmt1a, suv39h, suv39h1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (62 residues) CATH domain: 2.40.50.40
3n71
Crystal structure of cardiac specific histone methyltransfer
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: mcg_127279, smyd1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (468 residues) CATH domains: Unassigned Unassigned Unassigned
3ooi
Crystal structure of human histone-lysine n-methyltransferas domain in complex with s-adenosyl-l-methionine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nsd1, ara267, kmt3b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (232 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3ope
Structural basis of auto-inhibitory mechanism of histone methyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ash1l, kiaa1420, kmt2h. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (213 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3os5
Set7/9-dnmt1 k142me1 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (249 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3oxf
Human lysine methyltransferase smyd3 in complex with adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (426 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3oxg
Human lysine methyltransferase smyd3 in complex with adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (424 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3oxl
Human lysine methyltransferase smyd3 in complex with adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (426 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3pdn
Crystal structure of smyd3 in complex with methyltransferase sinefungin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (427 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SFG is 51.43% similar to enzyme product S-adenosylhomocysteine
3q0b
Crystal structure of suvh5 sra- fully methylated cg DNA comp space group p42212
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: at2g35160, sdg9, set9, suvh5, t4c15.17. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized
Chain: X (148 residues) CATH domain: Unassigned
3q0c
Crystal structure of suvh5 sra-fully methylated cg DNA compl space group p6122
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: at2g35160, sdg9, set9, suvh5, t4c15.17. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized
Chains: X, A (147 residues) CATH domain: Unassigned
3q0d
Crystal structure of suvh5 sra- hemi methylated cg DNA compl
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: at2g35160, sdg9, set9, suvh5, t4c15.17. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized. Other_details: chemically synthesized
Chains: X, A (140 residues) CATH domain: Unassigned
3q0f
Crystal structure of suvh5 sra- methylated chh DNA complex
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: at2g35160, sdg9, set9, suvh5, t4c15.17. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized. Other_details: chemically synthesized
Chains: X, A (145 residues) CATH domain: Unassigned
3qow
Dot1l structure in complex with sam
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (322 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3qox
Dot1l structure in complex with sah
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (326 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3qwp
Crystal structure of set and mynd domain containing 3; zinc mynd domain-containing protein 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (425 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3rjw
Crystal structure of histone lysine methyltransferase g9a wi inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt2, bat8, c6orf30, g9a, kmt1c, ng36. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (268 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3rq4
Crystal structure of suppressor of variegation 4-20 homolog
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: suv420h2, kmt5c, pp7130. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (240 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3ru0
Cocrystal structure of human smyd3 with inhibitor sinefungin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smyd3, zmynd1, znfn3a1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (425 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group SFG is 51.43% similar to enzyme product S-adenosylhomocysteine
3s8p
Crystal structure of the set domain of human histone-lysine methyltransferase suv420h1 in complex with s-adenosyl-l-met
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cgi-85, kmt5b, suv420h1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (233 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3s8s
Crystal structure of the rrm domain of human setd1a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd1a, kiaa0339, kmt2f, set1, set1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (107 residues) CATH domain: 3.30.70.330
3smt
Crystal structure of human set domain-containing protein3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd3, c14orf154. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (465 residues) CATH domains: 3.90.1410.10 3.90.1420.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3sr4
Crystal structure of human dot1l in complex with a selective
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group TT8 is 96.30% similar to enzyme product S-adenosylhomocysteine
3sw9
Glp (g9a-like protein) set domain in complex with dnmt3ak44m
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, glp, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.
Chains: A, B (261 residues) CATH domain: 2.170.270.10
3swc
Glp (g9a-like protein) set domain in complex with dnmt3ak44m
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, glp, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.
Chains: A, B (261 residues) CATH domain: 2.170.270.10
3sx0
Crystal structure of dot1l in complex with a brominated sah
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (324 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group SX0 is 89.29% similar to enzyme product S-adenosylhomocysteine
3u88
Crystal structure of human menin in complex with mll1 and le
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: men1, scg2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: all1, cxxc7, hrx, htrx, kmt2a, mll, mll1, trx1. Gene: dfs70, ledgf, psip1, psip2.
Chains: M, N (56 residues) CATH domain: Unassigned
3uvk
Crystal structure of wdr5 in complex with the wdr5-interacti of mll2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wdr5, big3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chain: B (11 residues)
3uwp
Crystal structure of dot1l in complex with 5-iodotubercidin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (341 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group 5ID is 58.62% similar to enzyme product S-adenosylhomocysteine
3vuz
Crystal structure of histone methyltransferase set7/9 in com aam-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: cell-free synthesis.
Chain: A (246 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group K15 is 45.00% similar to enzyme product S-adenosylhomocysteine
3vv0
Crystal structure of histone methyltransferase set7/9 in com daam-3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: cell-free synthesis.
Chain: A (235 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group KH3 is 41.86% similar to enzyme product S-adenosylhomocysteine
4au7
The structure of the suv4-20h2 ternary complex with histone
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 10090
Chains: A, B (243 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4bup
A novel route to product specificity in the suv4-20 family of histone h4k20 methyltransferases
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (232 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
4e47
Set7/9 in complex with inhibitor (r)-(3-(3-cyanophenyl)-1-ox (pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinolin sulfonamide and s-adenosylmethionine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (246 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
4ek9
Crystal structure of dot1l in complex with epz000004
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (325 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group EP4 is 62.07% similar to enzyme product S-adenosylhomocysteine
4ekg
Crystal structure of dot1l in complex with epz003696
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (319 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group 0QJ is 40.00% similar to enzyme product S-adenosylhomocysteine
4eki
Crystal structure of dot1l in complex with epz004777
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (319 residues) CATH domains: Unassigned 3.40.50.150
4eqz
Crystal structure of human dot1l in complex with inhibitor f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (332 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group AW0 is 40.91% similar to enzyme product S-adenosylhomocysteine
4er0
Crystal structure of human dot1l in complex with inhibitor f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (315 residues) CATH domains: Unassigned 3.40.50.150
4er3
Crystal structure of human dot1l in complex with inhibitor e
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (311 residues) CATH domains: Unassigned 3.40.50.150
4er5
Crystal structure of human dot1l in complex with 2 molecules epz004777
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (329 residues) CATH domains: Unassigned 3.40.50.150
4er6
Crystal structure of human dot1l in complex with inhibitor s
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (335 residues) CATH domains: Unassigned 3.40.50.150
4er7
Crystal structure of human dot1l in complex with inhibitor s
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (326 residues) CATH domains: Unassigned 3.40.50.150
4erq
X-ray structure of wdr5-mll2 win motif peptide binary comple
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: big3, wdr5. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: D, E, F (13 residues)
4ery
X-ray structure of wdr5-mll3 win motif peptide binary comple
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: big3, wdr5. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chain: D (14 residues)
4erz
X-ray structure of wdr5-mll4 win motif peptide binary comple
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: big3, wdr5. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: D, E, F (12 residues)
4esg
X-ray structure of wdr5-mll1 win motif peptide binary comple
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: big3, wdr5. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: C, D (16 residues)
4fmu
Crystal structure of methyltransferase domain of human set d containing protein 2 compound: pr-snf
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd2, hif1, hypb, kiaa1732, kmt3a, set2, hspc069. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (235 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group 0UM is 47.37% similar to enzyme product S-adenosylhomocysteine
4gnd
Crystal structure of nsd3 tandem phd5-c5hch domains
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: whsc1l1, nsd3, dc28. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (98 residues) CATH domain: Unassigned
4gne
Crystal structure of nsd3 tandem phd5-c5hch domains complexe peptide 1-7
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: whsc1l1, nsd3, dc28. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic
Chain: A (98 residues) CATH domain: Unassigned
4gnf
Crystal structure of nsd3 tandem phd5-c5hch domains complexe peptide 1-15
Source: Homo sapiens. Organism_taxid: 9606. Gene: whsc1l1, nsd3, dc28. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Human. Other_details: synthetic
Chain: A (96 residues) CATH domain: Unassigned
4gng
Crystal structure of nsd3 tandem phd5-c5hch domains complexe h3k9me3 peptide
Source: Homo sapiens. Organism_taxid: 9606. Gene: whsc1l1, nsd3, dc28. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Human. Other_details: synthetic
Chains: A, D (95 residues) CATH domain: Unassigned
4gq6
Human menin in complex with mll peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: men1, scg2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chain: B (12 residues)
4h12
The crystal structure of methyltransferase domain of human s containing protein 2 in complex with s-adenosyl-l-homocyste
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd2, hif1, hypb, kiaa1732, kmt3a, set2, hspc069. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (233 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4h4h
Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, glp, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: ( residues)
4hra
Crystal structure of dot1l in complex with epz-5676
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dot1l, kiaa1814, kmt4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (320 residues) CATH domains: Unassigned 3.40.50.150
4i51
Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt1, euhmtase1, glp, kiaa1876, kmt1d. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chains: A, B (261 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4ij8
Crystal structure of the complex of setd8 with sam
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd8, kmt5a, prset7, set07, set8. Expressed in: escherichia coli. Expression_system_taxid: 511693. Unidentified. Organism_taxid: 32644. Expression_system_taxid: 562
Chains: A, B (161 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
4ijd
Crystal structure of methyltransferase domain of human pr do containing protein 9
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prdm9, pfm6. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (215 residues) CATH domains: 2.170.270.10 3.30.160.60
4j7f
Set7/9y335paf in complex with taf10 peptide and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetically produced peptide
Chain: A (241 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4j7i
Set7/9y335f in complex with taf10 peptide and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetically produced peptide
Chain: A (244 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4j83
Set7/9 in complex with taf10k189a peptide and adomet
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetically produced peptide
Chain: A (242 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
4j8o
Set7/9 in complex with taf10k189a peptide and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetically produced peptide
Chain: A (245 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4jds
Setd7 in complex with inhibitor pf-5426 and s-adenosyl-methi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (245 residues) CATH domains: Unassigned 2.170.270.10
4jlg
Setd7 in complex with inhibitor (r)-pfi-2 and s-adenosyl-met
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd7, kiaa1717, kmt7, set7, set9. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (247 residues) CATH domains: Unassigned 2.170.270.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
4l58
Crystal structure of the mll5 phd finger in complex with h3k
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mll5, kmt2e. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the modified peptide was synthesized.
Chain: A (65 residues) CATH domain: Unassigned
4mi0
Human enhancer of zeste (drosophila) homolog 2(ezh2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ezh2, kmt6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (208 residues) CATH domain: 2.170.270.10
4mi5
Crystal structure of the ezh2 set domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ezh2, kmt6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (208 residues) CATH domain: 2.170.270.10
4nvq
Human g9a in complex with inhibitor a-366
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehmt2, bat8, c6orf30, g9a, kmt1c, ng36. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domain: 2.170.270.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4nw3
Crystal structure of mll cxxc domain in complex with a cpg d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kmt2a, all1, cxxc7, hrx, htrx, mll, mll1, trx1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes
Chain: A (51 residues) CATH domain: Unassigned
4o30
Crystal structure of atxr5 in complex with histone h3.1 and
Source: Ricinus communis. Castor bean. Organism_taxid: 3988. Gene: rcom_1460410. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide (genescript), histone h3
Chains: A, B (217 residues) CATH domain: Unassigned
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4pzi
Zinc finger region of mll2 in complex with cpg DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kmt2b, hrx2, kiaa0304, mll2, mll4, trx2, wbp7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic DNA
Chain: A (61 residues) CATH domain: Unassigned
4qen
Crystal structure of kryptonite in complex with mchh DNA and
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: suvh4, kyp, sdg33, set33, at5g13960, mac12.7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chain: A (472 residues)
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4qeo
Crystal structure of kryptonite in complex with mchh DNA, h3 peptide and sah
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: suvh4, kyp, sdg33, set33, at5g13960, mac12.7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Xenopus laevis. Clawed frog,common platanna,platanna.
Chain: A (472 residues)
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4qep
Crystal structure of kryptonite in complex with mchg DNA and
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: suvh4, kyp, sdg33, set33, at5g13960, mac12.7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chain: A (467 residues)
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine