PDBsum entry 2kso

Protein binding

PDB id: 2kso

Contents

Protein chains

65 a.a.

59 a.a.

PDB id:

2kso

Name:

Protein binding

Title:

Epha2:ship2 sam:sam complex

Structure:

Ephrin type-a receptor 2. Chain: a. Fragment: epha2 sam domain. Synonym: tyrosine-protein kinase receptor eck, epithelial cell kinase. Engineered: yes. Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. Chain: b. Fragment: ship2 sam domain.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: inppl1, ship2.

NMR struc:

15 models

Authors:

P.K.Hota,C.Preeti,L.Stetzik,S.Kim,B.Wang,H.Lee,M.Buck

Key ref:

H.Lee et al. Structure and function of the epha2:ship2 sam domain heterodimer. To be published, .

Date:

10-Jan-10 Release date: 27-Jul-11

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 65 a.a.

Protein chain

O15357  (SHIP2_HUMAN) -  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 from Homo sapiens

Seq: 1258 a.a.

Struc: 59 a.a.

Enzyme reactions

• Enzyme class 2: Chain A: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺
• Enzyme class 3: Chain B: E.C.3.1.3.86 - phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
• Reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4- bisphosphate) + phosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site