EC 3.1.3.86 - Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.1.3.86

Names

Accepted name:
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Other names:
SHIP1
SHIP
p150Ship
SHIP2
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase

Reaction

Comments:

This enzyme hydrolyses phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward PtdIns(1,3,4,5)P4 [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (16) [show] [UniProt]

References

  1. Lioubin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, A., Rohrschneider, L. R.
    p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
    Genes Dev. 10: 1084-1095 (1996). [PMID: 8654924]
  2. Damen, J. E., Liu, L., Rosten, P., Humphries, R. K., Jefferson, A. B., Majerus, P. W., Krystal, G.
    The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
    Proc. Natl. Acad. Sci. USA 93: 1689-1693 (1996). [PMID: 8643691]
  3. Giuriato, S., Payrastre, B., Drayer, A. L., Plantavid, M., Woscholski, R., Parker, P., Erneux, C., Chap, H.
    Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
    J. Biol. Chem. 272: 26857-26863 (1997). [PMID: 9341117]
  4. Drayer, A. L., Pesesse, X., De Smedt, F., Woscholski, R., Parker, P., Erneux, C.
    Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
    Biochem. Biophys. Res. Commun. 225: 243-249 (1996). [PMID: 8769125]
  5. Pesesse, X., Moreau, C., Drayer, A. L., Woscholski, R., Parker, P., Erneux, C.
    The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.
    FEBS Lett. 437: 301-303 (1998). [PMID: 9824312]

[EC 3.1.3.86 created 2011]