Torsional scans of sulfonamide S-C bonds in small model systems of a series of
arylsulfonamide factor Xa inhibitors were performed in order to investigate if
conformational effects can help to rationalise the observed SAR. Computational
results were in good agreement with the experimental data indicating that the
sulfonamide conformation plays an important role in determining the activity in
this particular series of factor Xa inhibitors.
