 |
PDBsum entry 2bkt
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Equipotent activity in both enantiomers of a series of ketopiperazine-Based renin inhibitors.
|
|
|
Authors
|
|
N.A.Powell,
E.H.Clay,
D.D.Holsworth,
J.W.Bryant,
M.J.Ryan,
M.Jalaie,
E.Zhang,
J.J.Edmunds.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2005,
15,
2371-2374.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
We have found that both enantiomeric configurations of the
6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin
inhibition activity and similar SAR patterns. This enantiomeric flexibility is
in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.
|
|
|
|
|
|
|
