PDBsum entry 2gzq

Lipid binding protein

PDB id: 2gzq

Contents

Protein chain

191 a.a. *

Waters ×282

* Residue conservation analysis

PDB id:

2gzq

Name:

Lipid binding protein

Title:

Phosphatidylethanolamine-binding protein from plasmodium vivax

Structure:

Phosphatidylethanolamine-binding protein. Chain: a. Engineered: yes

Source:

Plasmodium vivax. Malaria parasite p. Vivax. Organism_taxid: 5855. Gene: hpf.Pfl0955c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.30Å R-factor: 0.161 R-free: 0.180

Authors:

T.L.Arakaki,E.A.Merritt,Structural Genomics Of Pathogenic Protozoa Consortium (Sgpp)

Key ref:

T.Arakaki et al. (2007). The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix. Acta Crystallogr Sect F Struct Biol Cryst Commun, 63, 178-182. PubMed id: 17329808

Date:

11-May-06 Release date: 23-May-06

Protein chain

A5K000  (A5K000_PLAVS) -  Phosphatidylethanolamine-binding protein, putative from Plasmodium vivax (strain Salvador I)

Seq: 191 a.a.

Struc: 191 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Acta Crystallogr Sect F Struct Biol Cryst Commun 63:178-182 (2007)

PubMed id: 17329808

The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.

T.Arakaki, H.Neely, E.Boni, N.Mueller, F.S.Buckner, W.C.Van Voorhis, A.Lauricella, G.DeTitta, J.Luft, W.G.Hol, E.A.Merritt.

ABSTRACT

The structure of a putative Raf kinase inhibitor protein (RKIP) homolog from the eukaryotic parasite Plasmodium vivax has been studied to a resolution of 1.3 A using multiple-wavelength anomalous diffraction at the Se K edge. This protozoan protein is topologically similar to previously studied members of the phosphatidylethanolamine-binding protein (PEBP) sequence family, but exhibits a distinctive left-handed alpha-helical region at one side of the canonical phospholipid-binding site. Re-examination of previously determined PEBP structures suggests that the P. vivax protein and yeast carboxypeptidase Y inhibitor may represent a structurally distinct subfamily of the diverse PEBP-sequence family.