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PDBsum entry 2gzq
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Lipid binding protein
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PDB id
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2gzq
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References listed in PDB file
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Key reference
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Title
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The structure of plasmodium vivax phosphatidylethanolamine-Binding protein suggests a functional motif containing a left-Handed helix.
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Authors
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T.Arakaki,
H.Neely,
E.Boni,
N.Mueller,
F.S.Buckner,
W.C.Van voorhis,
A.Lauricella,
G.Detitta,
J.Luft,
W.G.Hol,
E.A.Merritt.
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Ref.
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Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007,
63,
178-182.
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PubMed id
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Abstract
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The structure of a putative Raf kinase inhibitor protein (RKIP) homolog from the
eukaryotic parasite Plasmodium vivax has been studied to a resolution of 1.3 A
using multiple-wavelength anomalous diffraction at the Se K edge. This protozoan
protein is topologically similar to previously studied members of the
phosphatidylethanolamine-binding protein (PEBP) sequence family, but exhibits a
distinctive left-handed alpha-helical region at one side of the canonical
phospholipid-binding site. Re-examination of previously determined PEBP
structures suggests that the P. vivax protein and yeast carboxypeptidase Y
inhibitor may represent a structurally distinct subfamily of the diverse
PEBP-sequence family.
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