EC - Cathepsin B

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IntEnz Enzyme Nomenclature


Accepted name:
cathepsin B
Other names:
cathepsin B1 [obsolete]
cathepsin II
Systematic name:



An intracellular (lysosomal) enzyme in peptidase family C1 (papain family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004213
CAS Registry Number: 9047-22-7
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Bond, J.S. and Barrett, A.J.
    Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase.
    Biochem. J. 189: 17-25 (1980). [PMID: 7458901]
  2. Barrett, A.J. and Kirschke, H.
    Cathepsin B, cathepsin H and cathepsin L.
    Methods Enzymol. 80C: 535-561 (1981). [PMID: 7043200]
  3. Polgár, L. and Csoma, C.
    Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.
    J. Biol. Chem. 262: 14448-14453 (1987). [PMID: 3312190]
  4. Barrett, A.J., Buttle, D.J. and Mason, R.W.
    Lysosomal cysteine proteinases.
    ISI Atlas of Science: Biochemistry 1: 256-260 (1988).
  5. Kirschke, H., Wikstrom, P. and Shaw, E.
    Active center differences between cathepsins L and B: the S1 binding region.
    FEBS Lett. 228: 128-130 (1988). [PMID: 3342870]

[EC created 1972]