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PDBsum entry 1ztl
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with n-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-2-{6-oxo- 5-[(quinolin-8-ylmethyl)-amino]-2-m-tolyl-6h-pyrimidin-1-yl}- acetamide
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Structure:
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Coagulation factor xi. Chain: a. Fragment: catalytic domain. Synonym: plasma thromboplastin antecedent, pta, fxi. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Resolution:
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2.60Å
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R-factor:
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0.208
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R-free:
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0.237
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Authors:
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P.Nagafuji,L.Jin,M.Rynkiewicz,J.Quinn,F.Bibbins,H.Meyers,R.Babine, J.E.Strickler,S.S.Abdel-Meguid
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Key ref:
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P.Nagafuji
et al.
Pyrimidinone inhibitors of a thrombolytic protease.
To be published,
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Date:
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27-May-05
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Release date:
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09-May-06
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PROCHECK
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Headers
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References
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P03951
(FA11_HUMAN) -
Coagulation factor XI from Homo sapiens
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Seq:
Struc:
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625 a.a.
237 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
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Enzyme class:
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E.C.3.4.21.27
- coagulation factor XIa.
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Reaction:
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Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
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Links
