PDBsum entry 1x88

Cell cycle

PDB id: 1x88

Contents

Protein chains

332 a.a. *

Ligands

ADP ×2

NAT ×2

Metals

_MG ×2

Waters ×698

* Residue conservation analysis

PDB id:

1x88

Name:

Cell cycle

Title:

Human eg5 motor domain bound to mg-adp and monastrol

Structure:

Kinesin-like protein kif11. Chain: a, b. Fragment: kinesin-motor. Synonym: kinesin-related motor protein eg5, kinesin-like spindle protein hksp, thyroid receptor interacting protein 5, trip5, kinesin- like protein 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kif11, knsl1, eg5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.80Å R-factor: 0.203 R-free: 0.225

Authors:

Z.Maliga,T.J.Mitchison

Key ref:

Z.Maliga and t.j.mitchison Structural basis of eg5 inhibition by monastrol. To be published, .

Date:

17-Aug-04 Release date: 15-Nov-05

Protein chains

P52732  (KIF11_HUMAN) -  Kinesin-like protein KIF11 from Homo sapiens

Seq: 1056 a.a.

Struc: 332 a.a.

Enzyme reactions

• Enzyme class: E.C.?