PDBsum entry 1pyh Go to PDB code:  Tunnel analysis for: 1pyh calculated with MOLE 2.0 PDB id 1pyh Tunnels calculated on whole structure Tunnels calculated excluding ligands View options MOLEonline 2.0 manipulation and visualization with HETATM: without HETATM:   5 tunnels, coloured by tunnel radius 41 tunnels, coloured by tunnel radius 41 tunnels, coloured as in list below Tunnels are interior spaces connected with the protein surrounding. Only channels longer than 15 Å are shown. Tunnels Free R Length HPathy HPhob Polar Rel Mut Residue..type Ligands Radius 1 2.57 2.57 32.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 175 A UNK 178 A UNK 182 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A UNK 222 A BCL 301 A BPH 401 A UNK 36 B UNK 38 B UNK 39 B UNK 63 B UNK 67 B UNK 129 B UNK 146 B UNK 150 B BCL 303 B UNK 22 V UNK 25 V UNK 20 X UNK 21 X UNK 24 X UNK 25 X 2 1.97 1.97 32.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BCL 302 A BPH 401 A UNK 99 B UNK 152 B UNK 153 B UNK 156 B UNK 160 B UNK 168 B UNK 172 B UNK 173 B UNK 186 B UNK 189 B UNK 192 B UNK 205 B UNK 273 B UNK 274 B UNK 276 B UNK 277 B UNK 280 B UNK 284 B UNK 287 B UNK 288 B BCL 303 B 3 1.55 1.55 33.2 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 175 A UNK 178 A UNK 182 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A UNK 222 A BCL 301 A BPH 401 A UNK 36 B UNK 38 B UNK 39 B UNK 63 B UNK 67 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B BCL 303 B UNK 22 V UNK 25 V UNK 20 X UNK 21 X UNK 24 X UNK 25 X 4 1.91 1.91 34.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 155 A UNK 157 A UNK 158 A UNK 159 A UNK 162 A UNK 167 A UNK 168 A UNK 177 A UNK 181 A UNK 184 A BCL 301 A BCL 302 A BPH 401 A UNK 152 B UNK 153 B UNK 186 B UNK 187 B UNK 190 B UNK 191 B UNK 195 B UNK 196 B UNK 205 B UNK 206 B UNK 209 B UNK 273 B UNK 274 B UNK 276 B UNK 277 B BCL 303 B BCL 304 B 5 1.67 1.67 36.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 189 A UNK 218 A UNK 219 A UNK 220 A BPH 401 A UNK 22 B UNK 23 B UNK 25 B UNK 51 B UNK 52 B UNK 53 B UNK 129 B UNK 132 B UNK 133 B UNK 135 B UNK 136 B UNK 139 B UNK 146 B UNK 147 B UNK 150 B UNK 12 N UNK 14 N UNK 13 P UNK 14 P 6 1.91 1.91 36.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 150 A UNK 153 A UNK 157 A UNK 167 A UNK 168 A UNK 177 A UNK 181 A UNK 184 A UNK 244 A BCL 301 A BCL 302 A BPH 401 A UNK 152 B UNK 153 B UNK 186 B UNK 205 B UNK 206 B UNK 207 B UNK 209 B UNK 210 B UNK 273 B UNK 274 B UNK 276 B UNK 277 B BCL 303 B BCL 304 B BPH 402 B 7 1.91 1.91 39.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 175 A UNK 178 A UNK 181 A UNK 182 A UNK 184 A UNK 185 A UNK 220 A UNK 222 A BCL 301 A BPH 401 A UNK 36 B UNK 38 B UNK 39 B UNK 63 B UNK 67 B UNK 126 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 22 V UNK 25 V UNK 20 X UNK 21 X UNK 24 X UNK 25 X 8 1.97 1.97 44.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 168 A UNK 169 A UNK 174 A UNK 177 A UNK 178 A UNK 181 A UNK 184 A UNK 260 A UNK 263 A BCL 301 A BCL 302 A BPH 401 A UNK 90 B UNK 91 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 160 B UNK 179 B UNK 180 B UNK 182 B UNK 184 B UNK 186 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B 9 2.59 2.59 49.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A BCL 301 A BCL 302 A BPH 401 A UNK 63 B UNK 67 B UNK 99 B UNK 126 B UNK 129 B UNK 146 B UNK 150 B UNK 156 B UNK 157 B UNK 160 B UNK 168 B UNK 172 B UNK 173 B UNK 178 B UNK 182 B UNK 186 B UNK 189 B UNK 192 B UNK 284 B UNK 287 B UNK 288 B BCL 303 B 10 1.61 1.61 50.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A BCL 301 A BCL 302 A BPH 401 A UNK 63 B UNK 67 B UNK 99 B UNK 126 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 156 B UNK 157 B UNK 160 B UNK 168 B UNK 172 B UNK 173 B UNK 178 B UNK 182 B UNK 186 B UNK 189 B UNK 192 B UNK 284 B UNK 287 B UNK 288 B BCL 303 B 11 2.18 2.18 50.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 185 A UNK 188 A UNK 189 A UNK 218 A UNK 219 A UNK 220 A BCL 301 A BPH 401 A UNK 22 B UNK 23 B UNK 25 B UNK 51 B UNK 52 B UNK 53 B UNK 56 B UNK 59 B UNK 60 B UNK 63 B UNK 129 B UNK 132 B UNK 135 B UNK 136 B UNK 139 B UNK 146 B UNK 150 B BCL 303 B UNK 12 N UNK 14 N UNK 13 P UNK 14 P 12 1.95 1.95 50.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 119 B UNK 120 B UNK 122 B UNK 123 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 160 B UNK 161 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 29 N UNK 30 N UNK 33 N UNK 34 N UNK 28 P UNK 31 P UNK 32 P 13 1.96 1.96 53.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 163 B UNK 166 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 29 L UNK 30 L UNK 33 L UNK 29 N UNK 32 N UNK 35 N 14 2.55 2.55 54.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 175 A UNK 178 A UNK 182 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A UNK 222 A BCL 301 A BPH 401 A UNK 36 B UNK 38 B UNK 39 B UNK 63 B UNK 67 B UNK 129 B UNK 146 B UNK 150 B BCL 303 B UNK 18 V UNK 19 V UNK 22 V UNK 25 V UNK 17 X UNK 20 X UNK 21 X UNK 25 X 15 1.81 1.81 55.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 185 A UNK 186 A UNK 188 A UNK 189 A UNK 193 A UNK 194 A UNK 207 A UNK 208 A UNK 209 A UNK 212 A UNK 216 A UNK 220 A UNK 222 A UNK 224 A UNK 225 A UNK 226 A UNK 229 A BPH 401 A UNK 146 B UNK 150 B UNK 232 B UNK 233 B UNK 234 B UNK 235 B UNK 236 B UNK 239 B UNK 66 C UNK 67 C UNK 68 C UNK 70 C UNK 121 C UNK 123 C UNK 127 C 16 2.53 2.53 55.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 119 B UNK 120 B UNK 122 B UNK 123 B UNK 126 B UNK 129 B UNK 146 B UNK 150 B UNK 157 B UNK 161 B UNK 162 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 29 N UNK 30 N UNK 33 N UNK 34 N UNK 28 P UNK 31 P UNK 32 P 17 1.54 1.54 56.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 175 A UNK 178 A UNK 182 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A UNK 222 A BCL 301 A BPH 401 A UNK 36 B UNK 38 B UNK 39 B UNK 63 B UNK 67 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B BCL 303 B UNK 18 V UNK 19 V UNK 22 V UNK 25 V UNK 17 X UNK 20 X UNK 21 X UNK 25 X 18 1.64 1.64 56.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 119 B UNK 120 B UNK 122 B UNK 123 B UNK 126 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 157 B UNK 161 B UNK 162 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 29 N UNK 30 N UNK 33 N UNK 34 N UNK 28 P UNK 31 P UNK 32 P 19 1.91 1.91 56.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 19 L UNK 22 L UNK 23 L UNK 25 L UNK 26 L UNK 29 L UNK 19 M UNK 21 N UNK 24 N UNK 25 N UNK 28 N UNK 29 N 20 1.69 1.69 57.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 185 A UNK 186 A UNK 189 A UNK 193 A UNK 194 A UNK 207 A UNK 208 A UNK 209 A UNK 212 A UNK 216 A UNK 219 A UNK 220 A UNK 222 A UNK 224 A UNK 225 A UNK 226 A UNK 229 A BPH 401 A UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 232 B UNK 233 B UNK 234 B UNK 235 B UNK 236 B UNK 239 B UNK 66 C UNK 67 C UNK 68 C UNK 70 C UNK 121 C UNK 123 C UNK 127 C 21 2.57 2.57 57.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 150 A UNK 153 A UNK 157 A UNK 167 A UNK 168 A UNK 177 A UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A UNK 244 A BCL 301 A BCL 302 A BPH 401 A UNK 63 B UNK 67 B UNK 126 B UNK 129 B UNK 146 B UNK 150 B UNK 156 B UNK 157 B UNK 160 B UNK 178 B UNK 182 B UNK 186 B UNK 205 B UNK 206 B UNK 207 B UNK 209 B UNK 210 B BCL 303 B BCL 304 B BPH 402 B 22 1.95 1.95 58.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A UNK 185 A UNK 218 A UNK 219 A UNK 220 A BCL 301 A BPH 401 A UNK 22 B UNK 23 B UNK 25 B UNK 51 B UNK 52 B UNK 53 B UNK 56 B UNK 59 B UNK 60 B UNK 63 B UNK 126 B UNK 129 B UNK 132 B UNK 135 B UNK 136 B UNK 139 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 12 N UNK 14 N UNK 13 P UNK 14 P 23 2.54 2.54 58.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 129 B UNK 146 B UNK 150 B UNK 157 B UNK 158 B UNK 162 B UNK 163 B UNK 166 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 29 L UNK 30 L UNK 33 L UNK 29 N UNK 32 N UNK 35 N 24 1.57 1.57 59.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 150 A UNK 153 A UNK 157 A UNK 167 A UNK 168 A UNK 177 A UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A UNK 244 A BCL 301 A BCL 302 A BPH 401 A UNK 63 B UNK 67 B UNK 126 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 156 B UNK 157 B UNK 160 B UNK 178 B UNK 182 B UNK 186 B UNK 205 B UNK 206 B UNK 207 B UNK 209 B UNK 210 B BCL 303 B BCL 304 B BPH 402 B 25 1.66 1.66 59.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BCL 302 A BPH 401 A UNK 95 B UNK 96 B UNK 98 B UNK 101 B UNK 111 B UNK 152 B UNK 153 B UNK 156 B UNK 160 B UNK 172 B UNK 173 B UNK 174 B UNK 175 B UNK 176 B UNK 185 B UNK 186 B UNK 189 B UNK 205 B UNK 273 B UNK 274 B UNK 276 B UNK 277 B UNK 280 B UNK 284 B BCL 303 B 26 1.66 1.66 59.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 157 B UNK 158 B UNK 162 B UNK 163 B UNK 166 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 29 L UNK 30 L UNK 33 L UNK 29 N UNK 32 N UNK 35 N 27 2.55 2.55 61.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 129 B UNK 146 B UNK 150 B UNK 157 B UNK 158 B UNK 162 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 19 L UNK 22 L UNK 23 L UNK 25 L UNK 26 L UNK 29 L UNK 19 M UNK 21 N UNK 24 N UNK 25 N UNK 28 N UNK 29 N 28 1.94 1.94 61.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 175 A UNK 178 A UNK 181 A UNK 182 A UNK 184 A UNK 185 A UNK 220 A UNK 222 A BCL 301 A BPH 401 A UNK 36 B UNK 38 B UNK 39 B UNK 63 B UNK 67 B UNK 126 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 18 V UNK 19 V UNK 22 V UNK 25 V UNK 17 X UNK 20 X UNK 21 X UNK 25 X 29 1.69 1.69 63.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 157 B UNK 158 B UNK 162 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 19 L UNK 22 L UNK 23 L UNK 25 L UNK 26 L UNK 29 L UNK 19 M UNK 21 N UNK 24 N UNK 25 N UNK 28 N UNK 29 N 30 1.94 1.94 69.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 148 B UNK 151 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 18 J UNK 19 J UNK 17 L UNK 18 L UNK 20 L UNK 21 L UNK 22 L UNK 25 L UNK 25 N UNK 28 N UNK 29 N 31 1.97 1.97 69.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 152 B UNK 153 B UNK 155 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B UNK 282 B UNK 285 B BCL 303 B UNK 16 C UNK 26 J UNK 27 J UNK 29 J UNK 30 J UNK 25 L UNK 26 L UNK 28 L UNK 29 L UNK 31 L UNK 32 L UNK 25 N UNK 28 N UNK 29 N 32 1.96 1.96 70.2 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A UNK 201 A BCL 301 A BPH 401 A UNK 23 B UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 131 B UNK 134 B UNK 138 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 14 L UNK 18 L UNK 22 L UNK 25 L UNK 13 N UNK 14 N UNK 18 N UNK 21 N UNK 25 N UNK 28 N UNK 29 N 33 1.98 1.98 71.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 124 B UNK 126 B UNK 127 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 19 N UNK 20 N UNK 22 N UNK 23 N UNK 25 N UNK 26 N UNK 29 N BCL 38 N UNK 18 O UNK 19 O UNK 22 O UNK 20 P UNK 21 P UNK 24 P UNK 25 P 34 2.54 2.54 76.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 122 B UNK 123 B UNK 124 B UNK 126 B UNK 127 B UNK 129 B UNK 146 B UNK 150 B UNK 157 B UNK 158 B UNK 162 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 19 N UNK 20 N UNK 22 N UNK 23 N UNK 25 N UNK 26 N UNK 29 N BCL 38 N UNK 18 O UNK 19 O UNK 22 O UNK 20 P UNK 21 P UNK 24 P UNK 25 P 35 1.64 1.64 75.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 188 A UNK 189 A UNK 220 A BCL 301 A BCL 302 A BPH 401 A UNK 63 B UNK 67 B UNK 95 B UNK 96 B UNK 98 B UNK 101 B UNK 111 B UNK 126 B UNK 129 B UNK 146 B UNK 150 B UNK 156 B UNK 157 B UNK 160 B UNK 172 B UNK 173 B UNK 174 B UNK 175 B UNK 176 B UNK 178 B UNK 182 B UNK 185 B UNK 186 B UNK 189 B UNK 284 B BCL 303 B 36 1.88 1.88 77.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 182 A UNK 184 A UNK 185 A UNK 186 A UNK 189 A UNK 193 A UNK 194 A UNK 207 A UNK 208 A UNK 209 A UNK 212 A UNK 216 A UNK 220 A UNK 222 A UNK 224 A UNK 225 A UNK 226 A UNK 229 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 126 B UNK 152 B UNK 153 B UNK 156 B UNK 157 B UNK 232 B UNK 233 B UNK 234 B UNK 235 B UNK 236 B UNK 239 B UNK 273 B UNK 274 B UNK 277 B BCL 303 B UNK 66 C UNK 67 C UNK 68 C UNK 70 C UNK 121 C UNK 123 C UNK 127 C 37 1.68 1.68 77.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A BCL 301 A BPH 401 A UNK 63 B UNK 67 B UNK 122 B UNK 123 B UNK 124 B UNK 126 B UNK 127 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 157 B UNK 158 B UNK 162 B UNK 175 B UNK 176 B UNK 177 B UNK 178 B UNK 182 B BCL 303 B UNK 19 N UNK 20 N UNK 22 N UNK 23 N UNK 25 N UNK 26 N UNK 29 N BCL 38 N UNK 18 O UNK 19 O UNK 22 O UNK 20 P UNK 21 P UNK 24 P UNK 25 P 38 1.58 1.58 77.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 185 A UNK 189 A UNK 219 A UNK 220 A BCL 301 A BCL 302 A BPH 401 A UNK 63 B UNK 67 B UNK 95 B UNK 96 B UNK 98 B UNK 101 B UNK 111 B UNK 126 B UNK 129 B UNK 133 B UNK 146 B UNK 147 B UNK 150 B UNK 156 B UNK 157 B UNK 160 B UNK 172 B UNK 173 B UNK 174 B UNK 175 B UNK 176 B UNK 178 B UNK 182 B UNK 185 B UNK 186 B UNK 189 B UNK 284 B BCL 303 B 39 1.96 1.96 86.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 148 B UNK 151 B UNK 152 B UNK 153 B UNK 154 B UNK 155 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B UNK 278 B BCL 303 B UNK 22 C UNK 23 C UNK 25 C UNK 26 C UNK 21 H UNK 22 H UNK 25 H UNK 18 J UNK 21 J UNK 22 J UNK 25 L UNK 25 N UNK 28 N UNK 29 N 40 1.95 1.95 87.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 148 B UNK 151 B UNK 152 B UNK 153 B UNK 154 B UNK 155 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 273 B UNK 274 B UNK 277 B UNK 278 B BCL 303 B UNK 23 C UNK 26 C UNK 27 C UNK 30 C UNK 60 C UNK 12 H UNK 14 H UNK 15 H UNK 18 H UNK 13 J UNK 16 J UNK 17 J UNK 18 J UNK 22 J UNK 25 L UNK 25 N UNK 28 N UNK 29 N 41 1.94 1.94 105.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 181 A UNK 184 A UNK 199 A BCL 301 A BPH 401 A UNK 122 B UNK 123 B UNK 126 B UNK 127 B UNK 145 B UNK 148 B UNK 151 B UNK 152 B UNK 153 B UNK 154 B UNK 155 B UNK 156 B UNK 157 B UNK 158 B UNK 160 B UNK 162 B UNK 175 B UNK 176 B UNK 182 B UNK 238 B UNK 239 B UNK 240 B UNK 241 B UNK 263 B UNK 273 B UNK 274 B UNK 277 B UNK 278 B BCL 303 B UNK 23 C UNK 27 C UNK 30 C UNK 34 C UNK 37 C UNK 38 C UNK 62 C UNK 72 C UNK 74 C UNK 75 C UNK 78 C UNK 82 C UNK 116 C UNK 14 J UNK 18 J UNK 22 J UNK 25 L UNK 25 N UNK 28 N UNK 29 N Residue-type_colouring Positive Negative Neutral Aliphatic Aromatic Pro & Gly Cysteine H,K,R D,E S,T,N,Q A,V,L,I,M F,Y,W P,G C Acknowledgement Tunnels were calculated by MOLE 2.0 program version 2.5.13.11.08 and visualized using Pymol 0.97rc.