PDBsum entry 6zg0

Hydrolase

PDB id: 6zg0

Contents

Protein chains

(+ 1 more) 143 a.a.

157 a.a.

Ligands

EDO ×17

BME ×8

PEG ×2

PGE

PDB id:

6zg0

Name:

Hydrolase

Title:

Sarm1 sam1-2 domains

Structure:

NAD(+) hydrolase sarm1. Chain: a, b, c, d, e, f, g, h. Synonym: hsarm1,NADP(+) hydrolase sarm1,sterile alpha and armadillo repeat protein,sterile alpha and tir motif-containing protein 1, sterile alpha motif domain-containing protein 2,sam domain-containing protein 2,tir-1 homolog,hstir. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sarm1, kiaa0524, samd2, sarm. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f

Authors:

M.Sporny,J.Guez-Haddad,T.Khazma,A.Yaron,M.Dessau,C.Mim,M.N.Isupov, R.Zalk,M.Hons,Y.Opatowsky

Key ref:

m.sporny et al. (2020). The structural basis for SARM1 inhibition and activation under energetic stress. Elife, 9, . PubMed id: 33185189

Date:

18-Jun-20 Release date: 11-Nov-20

Protein chains

Q6SZW1  (SARM1_HUMAN) -  NAD(+) hydrolase SARM1 from Homo sapiens

Seq: 724 a.a.

Struc: 143 a.a.

Protein chain

Q6SZW1  (SARM1_HUMAN) -  NAD(+) hydrolase SARM1 from Homo sapiens

Seq: 724 a.a.

Struc: 157 a.a.

Enzyme reactions

• Enzyme class 2: Chains A, B, C, D, E, F, G, H: E.C.3.2.2.- - ?????
• Enzyme class 3: Chains A, B, C, D, E, F, G, H: E.C.3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
• Reaction: NAD⁺ + H2O = ADP-D-ribose + nicotinamide + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Elife 9: (2020)

PubMed id: 33185189

The structural basis for SARM1 inhibition and activation under energetic stress.

m.sporny, j.guez-haddad, t.khazma, a.yaron, m.dessau, c.mim.n.isupov, r.zalk, m.hons, y.opatowsky.

ABSTRACT

No abstract given.