PDBsum entry 6tpm

Hydrolase

PDB id: 6tpm

Contents

Protein chain

358 a.a.

Ligands

PEG

MK7

MES

SO4 ×2

Metals

_CL

_ZN ×2

Waters ×312

PDB id:

6tpm

Name:

Hydrolase

Title:

Crystal structure of ampc from e.Coli with relebactam (mk-7655)

Structure:

Beta-lactamase. Chain: a. Synonym: cephalosporinase. Engineered: yes

Source:

Escherichia coli (strain k12). Organism_taxid: 83333. Gene: ampc, ampa, b4150, jw4111. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Resolution:

1.72Å R-factor: 0.170 R-free: 0.195

Authors:

P.A.Lang,T.M.Leissing,C.J.Schofield,J.Brem

Key ref:

P.A.Lang et al. Crystal structure of ampc from e.Coli with relebactam. To be published, . PubMed id: 33199391

Date:

13-Dec-19 Release date: 25-Nov-20

Protein chain

P00811  (AMPC_ECOLI) -  Beta-lactamase from Escherichia coli (strain K12)

Seq: 377 a.a.

Struc: 358 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)