PDBsum entry 4z29

Signaling protein

PDB id: 4z29

Contents

Protein chains

176 a.a.

Waters ×140

PDB id:

4z29

Name:

Signaling protein

Title:

Crystal structure of the magnetobacterial protein mtxa c-terminal domain

Structure:

Magnetotaxis protein mtxa. Chain: a, b. Fragment: c-terminal domain, unp residues 25-313. Engineered: yes

Source:

Magnetospirillum gryphiswaldense. Organism_taxid: 55518. Gene: mtxa, mgr_0208. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.03Å R-factor: 0.187 R-free: 0.227

Authors:

R.Zarivach,G.Davidov

Key ref:

G.Davidov et al. (2015). Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship. Front Mol Biosci, 2, 25. PubMed id: 26052516 DOI: 10.3389/fmolb.2015.00025

Date:

29-Mar-15 Release date: 03-Jun-15

Protein chains

A4TUL6  (A4TUL6_9PROT) -  Magnetotaxis protein MtxA from Magnetospirillum gryphiswaldense

Seq: 313 a.a.

Struc: 176 a.a.

DOI no: 10.3389/fmolb.2015.00025

Front Mol Biosci 2:25 (2015)

PubMed id: 26052516

Crystal structure of the magnetobacterial protein MtxA C-terminal domain reveals a new sequence-structure relationship.

G.Davidov, F.D.Müller, J.Baumgartner, R.Bitton, D.Faivre, D.Schüler, R.Zarivach.

ABSTRACT

Magnetotactic bacteria (MTB) are a diverse group of aquatic bacteria that have the magnetotaxis ability to align themselves along the geomagnetic field lines and to navigate to a microoxic zone at the bottom of chemically stratified natural water. This special navigation is the result of a unique linear assembly of a specialized organelle, the magnetosome, which contains a biomineralized magnetic nanocrystal enveloped by a cytoplasmic membrane. The Magnetospirillum gryphiswaldense MtxA protein (MGR_0208) was suggested to play a role in bacterial magnetotaxis due to its gene location in an operon together with putative signal transduction genes. Since no homology is found for MtxA, and to better understand the role and function of MtxA in MTBés magnetotaxis, we initiated structural and functional studies of MtxA via X-ray crystallography and deletion mutagenesis. Here, we present the crystal structure of the MtxA C-terminal domain and provide new insights into its sequence-structure relationship.