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PDBsum entry 4z29
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Signaling protein
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PDB id
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4z29
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the magnetobacterial protein mtxa c-Terminal domain reveals a new sequence-Structure relationship.
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Authors
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G.Davidov,
F.D.Müller,
J.Baumgartner,
R.Bitton,
D.Faivre,
D.Schüler,
R.Zarivach.
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Ref.
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Front Mol Biosci, 2015,
2,
25.
[DOI no: ]
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PubMed id
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Abstract
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Magnetotactic bacteria (MTB) are a diverse group of aquatic bacteria that have
the magnetotaxis ability to align themselves along the geomagnetic field lines
and to navigate to a microoxic zone at the bottom of chemically stratified
natural water. This special navigation is the result of a unique linear assembly
of a specialized organelle, the magnetosome, which contains a biomineralized
magnetic nanocrystal enveloped by a cytoplasmic membrane. The Magnetospirillum
gryphiswaldense MtxA protein (MGR_0208) was suggested to play a role in
bacterial magnetotaxis due to its gene location in an operon together with
putative signal transduction genes. Since no homology is found for MtxA, and to
better understand the role and function of MtxA in MTBés magnetotaxis, we
initiated structural and functional studies of MtxA via X-ray crystallography
and deletion mutagenesis. Here, we present the crystal structure of the MtxA
C-terminal domain and provide new insights into its sequence-structure
relationship.
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