PDBsum entry 4v1c

Hydrolase

PDB id: 4v1c

Contents

Protein chains

270 a.a.

252 a.a.

191 a.a.

Ligands

ARG-THR-BTK-GLN-THR-ALA-ARG ×6

GOL ×6

Metals

_ZN ×5

Obsolete entry

PDB id:

4v1c

Name:

Hydrolase

Title:

Sirtuin 3

Structure:

NAD-dependent protein deacetylase sirtuin-3, mitochondrial. Chain: a. Fragment: catalytic domain, unp residues 121-394. Synonym: hsirt3, regulatory protein sir2 homolog 3, sir2-like protein 3, sirt6. Engineered: yes. NAD-dependent protein deacetylase sirtuin-3, mitochondrial. Chain: b, e, g, k. Fragment: catalytic domain, unp residues 121-394.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta. Synthetic construct. Organism_taxid: 32630.

Resolution:

2.95Å R-factor: 0.227 R-free: 0.278

Authors:

Y.Wang,Q.Hao

Key ref:

X.Bao et al. (2014). Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Elife, 3, . PubMed id: 25369635 DOI: 10.7554/eLife.02999

Date:

25-Sep-14 Release date: 12-Nov-14

Protein chains

Q9NTG7  (SIR3_HUMAN) -  NAD-dependent protein deacetylase sirtuin-3, mitochondrial from Homo sapiens

Seq: 399 a.a.

Struc: 270 a.a.*

Protein chains

Q9NTG7  (SIR3_HUMAN) -  NAD-dependent protein deacetylase sirtuin-3, mitochondrial from Homo sapiens

Seq: 399 a.a.

Struc: 252 a.a.

Protein chain

Q9NTG7  (SIR3_HUMAN) -  NAD-dependent protein deacetylase sirtuin-3, mitochondrial from Homo sapiens

Seq: 399 a.a.

Struc: 191 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B, E, I: E.C.3.5.1.- - ?????

DOI no: 10.7554/eLife.02999

Elife 3: (2014)

PubMed id: 25369635

Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.

X.Bao, Y.Wang, X.Li, X.M.Li, Z.Liu, T.Yang, C.F.Wong, J.Zhang, Q.Hao, X.D.Li.

ABSTRACT

No abstract given.