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PDBsum entry 4e5o
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PDB id:
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Transferase
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Title:
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Crystal structure of mouse thymidylate synthase in complex with dump
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Structure:
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Thymidylate synthase. Chain: a, b, c, d, e, f. Synonym: ts, tsase. Engineered: yes
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.70Å
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R-factor:
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0.236
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R-free:
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0.292
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Authors:
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A.Dowiercial,A.Jarmula,W.Rypniewski,M.Sokolowska,T.Fraczyk,J.Ciesla, W.Rode
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Key ref:
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A.Dowiercial
et al.
(2009).
Crystal structures of substrate- And sulfate-Bound mo thymidylate synthase.
Pteridines,
20,
163.
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Date:
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14-Mar-12
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Release date:
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18-Apr-12
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Supersedes:
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PROCHECK
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Headers
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References
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P07607
(TYSY_MOUSE) -
Thymidylate synthase from Mus musculus
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Seq:
Struc:
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307 a.a.
287 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.45
- thymidylate synthase.
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Pathway:
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Folate Coenzymes
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Reaction:
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dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
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dUMP
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+
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(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
Bound ligand (Het Group name = )
corresponds exactly
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=
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7,8-dihydrofolate
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+
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dTMP
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
