_EC 2.1.1.45 Thymidylate synthase. 208 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,711 PDB entries]
EC 2.1.1.- Methyltransferases. [1,381 PDB entries]
EC 2.1.1.45 Thymidylate synthase. [208 PDB entries]    
1aiq

Pathway: Folate Coenzymes
Reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
 


5,10-methylenetetrahydrofolate
+
dUMP
=
dihydrofolate
+
dTMP
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 208 PDB entries in enzyme class E.C.2.1.1.45

  PDB code Protein
1aiq
Crystal structure of thymidylate synthase r126e mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1ajm
Crystal structure of thymidylate synthase r126e mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1an5
E. Coli thymidylate synthase in complex with cb3717
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
1aob
E. Coli thymidylate synthase complexed with ddurd
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group DDU is 75.00% similar to enzyme reactant dUMP
1axw
E. Coli thymidylate synthase in complex with methotrexate (mtx) and 2'-deoxyuridine 5'-monophosphate (dump)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group MTX is 94.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1b02
Crystal structure of thymidylate synthase a from bacillus su
Source: Bacillus subtilis. Organism_taxid: 1423. Strain: 168. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (279 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group C2F corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.24% similar to enzyme reactant dUMP
1bdu
E. Coli thymidylate synthase complexed with durd
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chain: A (265 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group DUR is 80.00% similar to enzyme reactant dUMP
1bid
E. Coli thymidylate synthase complexed with dump
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chain: A (265 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1bjg
D221(169)n mutant does not promote opening of the cofactor imidazolidine ring
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Plasmid: pthya-d169n
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group TMF corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.24% similar to enzyme reactant dUMP
1bko
Thermostable thymidylate synthase a from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: x2913.
Chains: A, B, C, D (278 residues) CATH domain: 3.30.572.10
1bkp
Thermostable thymidylate synthase a from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: x2913.
Chains: A, B (278 residues) CATH domain: 3.30.572.10
1bo7
Thymidylate synthase r179t mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: e. Coli chi-2913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: synthetic gene
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group U corresponds to enzyme reactant dUMP
1bo8
Thymidylate synthase r178t mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: e. Coli chi-2913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: synthetic gene
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group U corresponds to enzyme reactant dUMP
1bp0
Thymidylate synthase r23i mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: chi-2913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: synthetic gene
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1bp6
Thymidylate synthase r23i, r179t double mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: e. Coli chi-2913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: synthetic gene
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1bpj
Thymidylate synthase r178t, r179t double mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: e. Coli chi-2913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: synthetic gene
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1bq1
E. Coli thymidylate synthase mutant n177a in complex with cb 2'-deoxyuridine 5'-monophosphate (dump)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1bq2
E. Coli thymidylate synthase mutant n177a
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chain: A (264 residues) CATH domain: 3.30.572.10
1bsf
Thermostable thymidylate synthase a from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: x2913.
Chains: A, B (278 residues) CATH domain: 3.30.572.10
1bsp
Thermostable thymidylate synthase a from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: x2913.
Chains: A, B (277 residues) CATH domain: 3.30.572.10
1ci7
Ternary complex of thymidylate synthase from pneumocystis carinii
Source: Pneumocystis carinii. Organism_taxid: 4754. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (292 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1ddu
E. Coli thymidylate synthase in complex with cb3717 and 2', 5'-dideoxyuridine (ddurd)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group DDU is 75.00% similar to enzyme reactant dUMP
1dna
D221(169)n mutant does not promote opening of the cofactor imidazolidine ring
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913. Statagene).
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1ev5
Crystal structure analysis of ala167 mutant of escherichia c
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1ev8
Crystal structure analysis of cys167 mutant of escherichia c
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1evf
Crystal structure analysis of cys167 mutant of escherichia c
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1evg
Crystal structure analysis of cys167 mutant of escherichia c unmodified catalytic cysteine
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1f28
Crystal structure of thymidylate synthase from pneumocystis carinii bound to dump and bw1843u89
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (295 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group F89 is 46.00% similar to enzyme product 7,8-dihydrofolate
1f4b
Crystal structure of escherichia coli thymidylate synthase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1f4c
Crystal structure of e. Coli thymidylate synthase covalently at c146 with n-[tosyl-d-prolinyl]amino-ethanethiol
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.30.572.10
1f4d
Crystal structure of e. Coli thymidylate synthase c146s, l14 covalently modified at c143 with n-[tosyl-d-prolinyl]amino- ethanethiol
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
1f4e
Crystal structure of e. Coli thymidylate synthase complexed tosyl-d-proline
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1f4f
Crystal structure of e. Coli thymidylate synthase complexed 722
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group TP3 is 41.86% similar to enzyme product 7,8-dihydrofolate
1f4g
Crystal structure of e. Coli thymidylate synthase complexed 876
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.30.572.10
1ffl
Crystal structure of the apo-thymidylate synthase r166q muta
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (264 residues) CATH domain: 3.30.572.10
1fwm
Crystal structure of the thymidylate synthase r166q mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
1hvy
Human thymidylate synthase complexed with dump and raltitrex antifolate drug, is in the closed conformation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (288 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1hw3
Structure of human thymidylate synthase suggests advantages chemotherapy with noncompetitive inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (263 residues) CATH domain: 3.30.572.10
1hw4
Structure of thymidylate synthase suggests advantages of che with noncompetitive inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (263 residues) CATH domain: 3.30.572.10
1hzw
Crystal structure of human thymidylate synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (280 residues) CATH domain: 3.30.572.10
1i00
Crystal structure of human thymidylate synthase, ternary com dump and tomudex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (278 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1j3i
Wild-type plasmodium falciparum dihydrofolate reductase- thymidylate synthase (pfdhfr-ts) complexed with wr99210, NADPH, and dump
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (223 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
1j3j
Double mutant (c59r+s108n) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with pyrimethamine, NADPH, and dump
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (221 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
1j3k
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, NADPH, and dump
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (221 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
1jg0
Crystal structure of escherichia coli thymidylate synthasE C with 2'-deoxyuridine-5'-monophosphate and n,o-didansyl-l-ty
Source: Escherichia coli. Organism_taxid: 562. Gene: esherichia coli. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (263 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1jmf
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229a mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1jmg
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229g mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1jmh
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229i mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1jmi
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229s mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1jtq
E. Coli ts complex with dump and the pyrrolo(2,3-d)pyrimidin antifolate ly341770
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1jtu
E. Coli thymidylate synthase in a complex with dump and ly33 polyglutamylated pyrrolo(2,3-d)pyrimidine-based antifolate
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1ju6
Human thymidylate synthase complex with dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (286 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group LYA is 40.00% similar to enzyme product 7,8-dihydrofolate
1juj
Human thymidylate synthase bound to dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (286 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group LYA is 40.00% similar to enzyme product 7,8-dihydrofolate
1jut
E. Coli thymidylate synthase bound to dump and ly338529, a p 3-d)pyrimidine-based antifolate
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1kce
E. Coli thymidylate synthase mutant e58q in complex with cb3 2'-deoxyuridine 5'-monophosphate (dump)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1kzi
Crystal structure of ects/dump/thf complex
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group THG corresponds to enzyme product 7,8-dihydrofolate
1kzj
Crystal structure of ects w80g/dump/cb3717 complex
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1lca
Lactobacillus casei thymidylate synthase ternary complex with dump and cb3717
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1lcb
Lactobacillus casei thymidylate synthase ternary complex wit h2folate
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group DHF corresponds to enzyme product 7,8-dihydrofolate
  Het Group TMP corresponds to enzyme product dTMP
1lce
Lactobacillus casei thymidylate synthase ternary complex wit ch2thf
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group TMF corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1nce
Crystal structure of a ternary complex of e. Coli thymidylat d169c with dump and the antifolate cb3717
Source: Escherichia coli, escherichia coli o15 ,. Organism_taxid: 562,83334. Strain: , o157:h7. Gene: thya or b2827 or z4144 or ecs3684. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1nja
Thymidylate synthase, mutation, n229c with 2'-deoxycytidine monophosphate (dcmp)
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229c mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthase gene). Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group DCM is 90.48% similar to enzyme reactant dUMP
1njb
Thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Cell_line: chi-2913. Gene: n229c mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthase gene). Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1njc
Thymidylate synthase, mutation, n229d with 2'-deoxycytidine monophosphate (dcmp)
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229d mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthase gene). Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group DCM is 90.48% similar to enzyme reactant dUMP
1njd
Thymidylate synthase, mutation, n229d with 2'-deoxyuridine 5 monophosphate (dump)
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229d mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthase gene). Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1nje
Thymidylate synthase with 2'-deoxycytidine 5'-monophosphate
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthase gene). Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group DCM is 90.48% similar to enzyme reactant dUMP
1qqq
Crystal structure analysis of ser254 mutant of escherichia c thymidylate synthase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1rts
Thymidylate synthase from rat in ternary complex with dump a
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (280 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1syn
E. Coli thymidylate synthase in complex with bw1843u89 and 2'-deoxyuridine 5'-monophosphate (dump)
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group F89 is 46.00% similar to enzyme product 7,8-dihydrofolate
1tda
Structures of thymidylate synthase with a c-terminal deletio thE C-terminus in alignment of d/ump and ch2h4folate
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (315 residues) CATH domain: 3.30.572.10
1tdb
Structures of thymidylate synthase with a c-terminal deletio thE C-terminus in alignment of d/ump and ch2h4folate
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (315 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UFP is 95.24% similar to enzyme reactant dUMP
1tdc
Structures of thymidylate synthase with a c-terminal deletio thE C-terminus in alignment of d/ump and ch2h4folate
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (315 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1tdu
E. Coli thymidylate synthase in complex with cb3717 and 2'- deoxyuridine (durd)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group DUR is 80.00% similar to enzyme reactant dUMP
1thy
Refined structures of substrate-bound and phosphate-bound th synthase from lactobacillus casei
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1tis
Crystal structure of thymidylate synthase from t4 phage
Source: Enterobacteria phage t4. Organism_taxid: 10665
Chain: A (286 residues) CATH domain: 3.30.572.10
1tjs
E. Coli thymidylate synthase
Source: Escherichia coli. Organism_taxid: 562. Cell_line: chi-2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: chi-2913.
Chain: A (265 residues) CATH domain: 3.30.572.10
1tlc
Thymidylate synthase complexed with dgmp and folate analog 1
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group DGP is 79.17% similar to enzyme reactant dUMP
  Het Group F89 is 46.81% similar to enzyme product 7,8-dihydrofolate
1tls
Thymidylate synthase ternary complex with fdump and methylenetetrahydrofolate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain lacks host thymidylate synthase gene
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group C2F corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.24% similar to enzyme reactant dUMP
1trg
E. Coli thymidylate synthase in symmetric complex with cb371 deoxyuridine 5'-monophosphate (dump)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1tsd
Thymidylate synthase complex with 2'-deoxyuridine 5'- monophosphate (dump) and folate analog 1843u89
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (265 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group F89 is 46.00% similar to enzyme product 7,8-dihydrofolate
1tsl
L. Casei thymidylate synthase with species specific inhibito
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
1tsm
L. Casei thymidylate synthase with species specific inhibito
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
1tsn
Thymidylate synthase ternary complex with fdump and methylenetetrahydrofolate
Source: Escherichia coli. Organism_taxid: 562
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group C2F corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.24% similar to enzyme reactant dUMP
1tsv
Thymidylate synthase r179a mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1tsw
Thymidylate synthase r179a mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
1tsx
Thymidylate synthase r179e mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1tsy
Thymidylate synthase r179k mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1tsz
Thymidylate synthase r179k mutant
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: purchased from sigma
Chain: A (316 residues) CATH domain: 3.30.572.10
1tvu
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229a mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1tvv
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229c mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1tvw
Contributions of orientation and hydrogen bonding to catalys 229 mutants of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: n229s mutant of cloned l. Case. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1tys
Water-mediated substrate(slash)product discrimination: the p complex of thymidylate synthase at 1.83 angstroms
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group DHF corresponds to enzyme product 7,8-dihydrofolate
  Het Group TMP corresponds to enzyme product dTMP
1vza
Thymidylate synthase e60d mutant binary complex with 2'- deoxyuridine 5'-monophosphate (dump)
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thymidylate synthase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1vzb
L. Casei thymidylate synthase mutant e60q binary complex with dump
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thymidylate synthase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
1vzc
L. Casei thymidylate synthase mutant e60q binary complex with fdump
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thymidylate synthase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UFP is 95.00% similar to enzyme reactant dUMP
1vzd
L. Casei thymidylate synthase mutant e60q ternary complex with fdump and cb3717
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thymidylate synthase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.00% similar to enzyme reactant dUMP
1vze
L. Casei thymidylate synthase mutant e60q ternary complex with dump and cb3717
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thymidylate synthase. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
1ypv
Structure of human thymidylate synthase at low salt conditio
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
1zpr
E. Coli thymidylate synthase mutant e58q in complex with cb3 2'-deoxyuridine 5'-monophosphate (dump)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2a9w
E. Coli ts complexed with dump and inhibitor ga9
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2aaz
Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate
Source: Filobasidiella neoformans. Organism_taxid: 5207. Gene: tmp1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P (305 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2bbq
Structural basis for recognition of polyglutamyl folates by thymidylate synthase
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2bl9
X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (216 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group CP6 is 42.00% similar to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
2bla
Sp21 double mutant p. Vivax dihydrofolate reductase in complex with pyrimethamine
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (217 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group CP6 is 42.00% similar to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
2blb
X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (218 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group CP7 is 44.00% similar to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
2blc
Sp21 double mutant p. Vivax dihydrofolate reductase in complex with des-chloropyrimethamine
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (215 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group CP7 is 44.00% similar to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
2ftn
E. Coli thymidylate synthase y94f mutant
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
2fto
Y94f mutant of thymidylate synthase bound to thymidine-5'-ph and 10-propargyl-5,8-dideazafolid acid
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group TMP corresponds to enzyme product dTMP
2ftq
E. Coli thymidylate synthase at 1.8 a resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
2g86
L. Casei thymidylate synthase y261f in complex with substrat
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2g89
L. Casei thymidylate synthase y261a in complex with substrat
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2g8a
Lactobacillus casei y261m in complex with substrate, dump
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2g8d
Lactobacillus casei thymidylate synthase y261w-dump complex
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2g8m
Escherichia coli thymidylate synthase y209w in complex with dump, and a cofactor analog, cb3717
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2g8o
High resolution structure of escherichia coli thymidylate sy ternary complex with dump and a cofactor analog, cb3717
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2g8x
Escherichia coli y209w apoprotein
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.30.572.10
2h2q
Crystal structure of trypanosoma cruzi dihydrofolate reducta thymidylate synthase
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (514 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligands:   Het Group DU corresponds to enzyme reactant dUMP
  Het Group NAP is 40.82% similar to enzyme product dTMP
2kce
Binding of the anticancer drug zd1694 to e. Coli thymidylate assessing specificity and affinity
Source: Escherichia coli. Organism_taxid: 562. Cell_line: x2913. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2onb
Human thymidylate synthase at low salt conditions with pdpa
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (264 residues) CATH domain: 3.30.572.10
2rd8
Human thymidylate synthase stabilized in active conformation by r163k mutation: asymmetry and reactivity of cys195
Source: Homo sapiens. Human. Gene: tyms, ts. Expressed in: escherichia coli. Expressed in: escherichia coli
Chains: A, B (283 residues) CATH domain: 3.30.572.10
2rda
Human thymidylate synthase stabilized in active conformation by r163k mutation: asymmetry and reactivity of cys195
Source: Homo sapiens. Human. Gene: tyms, ts. Expressed in: escherichia coli
Chains: A, B, C, D, E, F (282 residues) CATH domain: 3.30.572.10
2tdd
Structures of thymidylate synthase with a c-terminal deletio thE C-terminus in alignment of d/ump and ch2h4folate
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (315 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group THF is 97.06% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.24% similar to enzyme reactant dUMP
2tdm
Structure of thymidylate synthase
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain chi-2913 lacks a thymidylate synthase
Chain: A (316 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2tsc
Structure, multiple site binding, and segmental accomodation in thymidylate synthase on binding d/ump and an anti-folate
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.00% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2tsr
Thymidylate synthase from rat in ternary complex with dump a
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (281 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
2vet
Crystal structure of the thymidylate synthase k48q complexed with dump
Source: Escherichia coli. Organism_taxid: 511693. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
2vf0
Crystal structure of the thymidylate synthase k48q complexed with 5no2dump and bw1843u89
Source: Escherichia coli. Organism_taxid: 511693. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group NDU is 86.00% similar to enzyme reactant dUMP
  Het Group F89 is 46.00% similar to enzyme product 7,8-dihydrofolate
3b5b
Crystal structure of the thymidylate synthase k48q
Source: Escherichia coli bl21. Organism_taxid: 511693. Strain: bl21. Gene: thya. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group NDU is 86.96% similar to enzyme reactant dUMP
3b9h
E. Coli thymidylate synthase complexed with 5-nitro-2'-deoxy
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group NDU is 86.96% similar to enzyme reactant dUMP
3bfi
E. Coli thymidylate synthase y209m mutant complexed with 5-n
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group NDU is 86.96% similar to enzyme reactant dUMP
3bgx
E. Coli thymidylate synthase c146s mutant complexed with dtm
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group MEF corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group TMP corresponds to enzyme product dTMP
3bhl
E.Coli thymidylate synthase complexes with 5-no2dump and tetrahydrofolate at 1.4 a resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group NDU is 86.96% similar to enzyme reactant dUMP
  Het Group THG corresponds to enzyme product 7,8-dihydrofolate
3bhr
E. Coli ts complexed with 5-no2dump and tetrahydrofolate at resolution (space group 152)
Source: Escherichia coli. Organism_taxid: 562. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group NDU is 86.96% similar to enzyme reactant dUMP
  Het Group THG corresponds to enzyme product 7,8-dihydrofolate
3bnz
Crystal structure of thymidylate synthase ternary complex wi and 8a inhibitor
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3byx
Lactobacillus casei thymidylate synthase ternary complex wit the phtalimidic derivative c00 in multiple binding modes
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (313 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3bz0
Lactobacillus casei thymidylate synthase ternary complex wit the phtalimidic derivative c00
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3c06
Lactobacillus casei thymidylate synthase ternary complex wit the phtalimidic derivative 14c in multiple binding modes-mo
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (303 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3c0a
Lactobacillus casei thymidylate synthase ternary complex wit the phtalimidic derivative 14c in multiple binding modes-mo
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (289 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3cl9
Structure of bifunctional tcdhfr-ts in complex with mtx
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (505 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligands:   Het Group MTX is 94.12% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NAP is 40.82% similar to enzyme product dTMP
3clb
Structure of bifunctional tcdhfr-ts in complex with tmq
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (510 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NAP is 40.82% similar to enzyme product dTMP
3dg8
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf670, NADPH, and dump
Source: Plasmodium falciparum. Organism_taxid: 5833. Strain: v1/s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (221 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
3dga
Wild-type plasmodium falciparum dihydrofolate reductase- thymidylate synthase (pfdhfr-ts) complexed with rjf01302, NADPH, and dump
Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (219 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
3eaw
Replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (258 residues) CATH domain: 3.30.572.10
3ebu
Replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domain: 3.30.572.10
3ed7
Replacement of val3 in human thymidylate synthase affects it properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (284 residues) CATH domain: 3.30.572.10
3edw
Replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (260 residues) CATH domain: 3.30.572.10
3ef9
Replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domain: 3.30.572.10
3egy
Crystal structure of human thymidyalte synthase a191k with l 197 stabilized in the inactive conformation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (234 residues) CATH domain: 3.30.572.10
3ehi
Crystal structure of human thymidyalte synthase m190k with l 197 stabilized in the inactive conformation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (273 residues) CATH domain: 3.30.572.10
3ejl
Replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (283 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UFP is 95.00% similar to enzyme reactant dUMP
3gg5
Replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (283 residues) CATH domain: 3.30.572.10
3gh0
Replacement of val3 in human thymidylate synthase affects it properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (284 residues) CATH domain: 3.30.572.10
3gh2
Replacement of val3 in human thymidylate synthase affects it properties and intracellular stability
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (276 residues) CATH domain: 3.30.572.10
3h9k
Structures of thymidylate synthase r163k with substrates and inhibitors show subunit asymmetry
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (281 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UFP is 95.24% similar to enzyme reactant dUMP
3hb8
Structures of thymidylate synthase r163k with substrates and inhibitors show subunit asymmetry
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (281 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3hbb
Structures of dihydrofolate reductase-thymidylate synthase o trypanosoma cruzi in the folate-free state and in complex w antifolate drugs, trimetrexate and methotrexate
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Gene: dhfr-ts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (510 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NAP is 40.82% similar to enzyme product dTMP
3ihh
Crystal structure of mouse thymidylate synthase in complex w
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (287 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3ihi
Crystal structure of mouse thymidylate synthase
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (280 residues) CATH domain: 3.30.572.10
3ijz
Lactobacillus casei thymidylate synthase ternary complex wit pthalimidic derivative 15c
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3ik0
Lactobacillus casei thymidylate synthase in ternary complex and the phtalimidic derivative 7c1
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3ik1
Lactobacillus casei thymidylate synthase in ternary complex and the phtalimidic derivative 20c
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (311 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3inv
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with NADPH, dump and c-448 antifolate
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (514 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group NDP is 40.82% similar to enzyme product dTMP
3irm
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with cycloguanil
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (520 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group 1CY is 42.00% similar to enzyme reactant dUMP
3irn
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with NADPH and cycloguanil
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (516 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligands:   Het Group 1CY is 42.00% similar to enzyme reactant dUMP
  Het Group NDP is 40.00% similar to enzyme product dTMP
3iro
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with NADPH and q-8 antifolate
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (518 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NDP is 40.00% similar to enzyme product dTMP
3ix6
Crystal structure of thymidylate synthase thya from brucella melitensis
Source: Brucella melitensis. Organism_taxid: 29459. Gene: thya, bmei0608. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.30.572.10
3kgb
Crystal structure of thymidylate synthase 1/2 from encephali cuniculi at 2.2 a resolution
Source: Encephalitozoon cuniculi. Microsporidian parasite. Organism_taxid: 284813. Strain: gb-m1. Gene: ts-1, ecu01_0180, ts-2, ecu01_1430. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (254 residues) CATH domain: 3.30.572.10
3n5e
Crystal structure of human thymidylate synthase bound to a p inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide (8mer)
Chains: A, B (263 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group ARG is 40.91% similar to enzyme reactant dUMP
3n5g
Crystal structure of histidine-tagged human thymidylate synt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (263 residues) CATH domain: 3.30.572.10
3ob7
Human thymidylate synthase r163k with cys 195 covalently mod glutathione
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E (281 residues) CATH domain: 3.30.572.10
3qfx
Trypanosoma brucei dihydrofolate reductase pyrimethamine com
Source: Trypanosoma brucei rhodesiense. Organism_taxid: 31286. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (219 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group CP6 is 42.31% similar to enzyme reactant dUMP
  Het Group NDP is 40.82% similar to enzyme product dTMP
3qj7
Crystal structure of the mycobacterium tuberculosis thymidyl synthase (thya) bound to dump
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mt2834, mtv002.29c, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (260 residues)
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
3rg9
Trypanosoma brucei dihydrofolate reductase (tbdhfr) in compl wr99210
Source: Trypanosoma brucei rhodesiense. Organism_taxid: 31286. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (218 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP is 40.82% similar to enzyme product dTMP
3tms
Plastic adaptation toward mutations in proteins: structural of thymidylate synthases
Source: Escherichia coli. Organism_taxid: 562
Chain: A (264 residues) CATH domain: 3.30.572.10
3uwl
Crystal structure of enteroccocus faecalis thymidylate synth in complex with 5-formyl tetrahydrofolate
Source: Enterococcus faecalis. Organism_taxid: 1351. Gene: ef_1576, thya. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (292 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group FOZ is 97.06% similar to enzyme reactant 5,10-methylenetetrahydrofolate
3v8h
Crystal structure of thymidylate synthase from burkholderia thailandensis
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264/atcc 700388/dsm 13276/cip 106301. Gene: thya, bth_i1680. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (312 residues) CATH domain: 3.30.572.10
4dq1
Thymidylate synthase from staphylococcus aureus.
Source: Staphylococcus aureus. Organism_taxid: 158878. Strain: subsp. Aureus mu50. Gene: sav1427, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (312 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4e28
Structure of human thymidylate synthase in inactive conforma a novel non-peptidic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (251 residues) CATH domain: 3.30.572.10
4e5o
Crystal structure of mouse thymidylate synthase in complex w
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (287 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4eb4
Crystal structure of mouse thymidylate synthase in ternary c with dump and tomudex
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (300 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
4eck
Crystal structure of the toxoplasma gondii ts-dhfr
Source: Toxoplasma gondii. Organism_taxid: 5811. Strain: k-12. Gene: drts. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (498 residues) CATH domains: 3.40.430.10 Unassigned 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group FOL corresponds to enzyme product 7,8-dihydrofolate
4eil
Crystal structure of the loop truncated toxoplasma gondii ts
Source: Toxoplasma gondii. Organism_taxid: 5811. Strain: k-12. Gene: drts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (510 residues) CATH domains: 3.40.430.10 Unassigned 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group FOL corresponds to enzyme product 7,8-dihydrofolate
4ez8
Crystal structure of mouse thymidylate sythase in ternary co n(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofa product, dihydrofolate
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (287 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group NOH is 86.36% similar to enzyme reactant dUMP
  Het Group DHF corresponds to enzyme product 7,8-dihydrofolate
4f2v
Crystal structure of de novo designed serine hydrolase, nort structural genomics consortium (nesg) target or165
Source: Artificial gene. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.30.572.10
4fgt
Allosteric peptidic inhibitor of human thymidylate synthase stabilizes inactive conformation of the enzyme.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic. Organism_taxid: 32630
Chain: A (267 residues) CATH domain: 3.30.572.10
4foa
Crystal structure of the mtb thya in complex with 5-fluoro-d
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: mt2834, mtv002.29c, rv2764c, thya. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (261 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UFP corresponds to enzyme reactant dUMP
4fog
Crystal structure of mtb thya in complex with 5-fluoro-dump methyltetrahydrofolic acid
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: mt2834, mtv002.29c, rv2764c, thya. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (260 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group C2F corresponds to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UFP is 95.24% similar to enzyme reactant dUMP
4fox
Crystal structure of mtb thya in complex with dump and ralti
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: mt2834, mtv002.29c, rv2764c, thya. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (261 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
4fqs
Crystal structure of mycobacterium tuberculosis thya in comp ump and pemetrexed
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Gene: mt2834, mtv002.29c, rv2764c, thya. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (263 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group UMP corresponds to enzyme reactant dUMP
  Het Group LYA is 40.00% similar to enzyme product 7,8-dihydrofolate
4g2o
Human thymidylate synthase m190k with bound purpurogallin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ok/sw-cl.29, ts, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (273 residues) CATH domain: 3.30.572.10
4g6w
Human thymidylate synthase m190k with bound 4-bromobenzene-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (270 residues) CATH domain: 3.30.572.10
4g9u
Crystal structure of trichinella spiralis thymidylate syntha complexed with dump
Source: Trichinella spiralis. Trichina worm. Organism_taxid: 6334. Gene: ts, tsp_03568, tyms. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (284 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4gd7
Wild-type human thymidylate synthase with bound purpurogalli
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tys, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (273 residues) CATH domain: 3.30.572.10
4gev
E. Coli thymidylate synthase y209w variant in complex with s and a cofactor analog
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b2827, jw2795, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMC corresponds to enzyme reactant dUMP
4gyh
Structure of human thymidylate synthase at high salt conditi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (263 residues) CATH domain: 3.30.572.10
4h0r
Crystal structure of thymidylate synthase from corynebacteri glutamicum
Source: Corynebacterium glutamicum. Organism_taxid: 196627. Strain: atcc 13032 / dsm 20300 / jcm 1318 / lmg 3730 / ncim gene: cg0966, cgl0844, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (256 residues) CATH domain: 3.30.572.10
4h0u
Crystal structure of thymidylate synthase from corynebacteri glutamicum in complex with dump
Source: Corynebacterium glutamicum. Organism_taxid: 196627. Strain: atcc 13032 / dsm 20300 / jcm 1318 / lmg 3730 / ncim gene: cg0966, cgl0844, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (260 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4h1i
Structure of human thymidylate synthase at low salt conditio
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (281 residues) CATH domain: 3.30.572.10
4iqb
High resolution crystal structure of c.Elegans thymidylate s
Source: Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (288 residues) CATH domain: 3.30.572.10
4iqq
Crystal structure of c.Elegans thymidylate synthase in compl dump and tomudex
Source: Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (289 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group D16 is 47.73% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMP corresponds to enzyme reactant dUMP
4irr
Crystal structure of c.Elegans thymidylate synthase in compl dump
Source: Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (290 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4isk
Crystal structure of e.Coli thymidylate synthase with dump a 945 inhibitor
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: thya, b2827, jw2795. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (264 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4isw
Crystal structure of phosphorylated c.Elegans thymidylate sy complex with dump
Source: Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (290 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4iw5
Thymidylate synthase ternary complex with dump and cb3717
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b2827, jw2795, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMC corresponds to enzyme reactant dUMP
4knz
Thymidylate synthase ternary complex with dump and cb3717
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b2827, jw2795, thya. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.30.572.10
Bound ligands:   Het Group CB3 is 51.11% similar to enzyme reactant 5,10-methylenetetrahydrofolate
  Het Group UMC corresponds to enzyme reactant dUMP
4kpw
Crystal structure of his-tagged human thymidylate synthase r mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyms, ts, ok/sw-cl.29. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (265 residues) CATH domain: 3.30.572.10
4lrr
Ternary complex between e. Coli thymidylate synthase, dump,
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: thya. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (265 residues) CATH domain: 3.30.572.10
Bound ligand:   Het Group UMP corresponds to enzyme reactant dUMP
4tms
Plastic adaptation toward mutations in proteins: structural of thymidylate synthases
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (316 residues) CATH domain: 3.30.572.10