PDBsum entry 4dkc

Cytokine

PDB id

4dkc

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Contents

			Protein chain

					161 a.a.

			Ligands

					NAG-NAG-BMA ×2

			Waters ×446

PDB id:

4dkc

Links

Name:

Cytokine

Title:

Crystal structure of human interleukin-34

Structure:

Interleukin-34. Chain: a, b. Synonym: il-34. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: il34, c16orf77. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tni pro

Resolution:

1.85Å

R-factor:

0.175

R-free:

0.203

Authors:

X.Ma,J.F.Bazan,M.A.Starovasnik

Key ref:

X.Ma et al. (2012). Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 676-687. PubMed id: 22483114

Date:

03-Feb-12

Release date:

11-Apr-12

PROCHECK

	Headers

	References

Protein chains

Q6ZMJ4 (IL34_HUMAN) - Interleukin-34 from Homo sapiens

Seq: Struc:					242 a.a. 161 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Structure 20:676-687 (2012)
PubMed id: 22483114

Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
X.Ma, W.Y.Lin, Y.Chen, S.Stawicki, K.Mukhyala, Y.Wu, F.Martin, J.F.Bazan, M.A.Starovasnik.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22902366

J.Elegheert, N.Bracke, P.Pouliot, I.Gutsche, A.V.Shkumatov, N.Tarbouriech, K.Verstraete, A.Bekaert, W.P.Burmeister, D.I.Svergun, B.N.Lambrecht, B.Vergauwen, and S.N.Savvides (2012).
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.

Nat Struct Mol Biol, 19, 938-947.

PDB codes:

3uez 3uf2 3uf5 4adf 4adq

23076159

K.Verstraete, and S.N.Savvides (2012).
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.

Nat Rev Cancer, 12, 753-766.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.