PDBsum entry 3vcm

Hydrolase

PDB id: 3vcm

Contents

Protein chains

335 a.a.

38 a.a.

25 a.a.

Ligands

NAG

Waters ×97

PDB id:

3vcm

Name:

Hydrolase

Title:

Crystal structure of human prorenin

Structure:

Prorenin. Chain: a, b. Fragment: renin (unp residues 67-406). Synonym: angiotensinogenase. Engineered: yes. Prorenin. Chain: p, q. Fragment: activation peptide (unp residues 24-66). Synonym: angiotensinogenase.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek. Expression_system_cell_line: hek

Resolution:

2.93Å R-factor: 0.214 R-free: 0.248

Authors:

R.Morales,Y.Watier,Z.Bocskei

Key ref:

R.Morales et al. (2012). Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor. J Mol Biol, 421, 100-111. PubMed id: 22575890

Date:

04-Jan-12 Release date: 23-May-12

Protein chains

P00797  (RENI_HUMAN) -  Renin from Homo sapiens

Seq: 406 a.a.

Struc: 335 a.a.

Protein chain

P00797  (RENI_HUMAN) -  Renin from Homo sapiens

Seq: 406 a.a.

Struc: 38 a.a.

Protein chain

P00797  (RENI_HUMAN) -  Renin from Homo sapiens

Seq: 406 a.a.

Struc: 25 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, P, Q: E.C.3.4.23.15 - renin.
• Reaction: Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.

J Mol Biol 421:100-111 (2012)

PubMed id: 22575890

Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor.

R.Morales, Y.Watier, Z.Böcskei.

ABSTRACT

No abstract given.