PDBsum entry 3rdh

Signaling protein/inhibitor

PDB id: 3rdh

Contents

Protein chains

233 a.a.

Ligands

3RD ×4

Metals

_NI ×4

Waters ×86

PDB id:

3rdh

Name:

Signaling protein/inhibitor

Title:

X-ray induced covalent inhibition of 14-3-3

Structure:

14-3-3 protein zeta/delta. Chain: a, b, c, d. Synonym: protein kinasE C inhibitor protein 1, kcip-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ywhaz. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.39Å R-factor: 0.235 R-free: 0.287

Authors:

J.R.Horton,A.K.Upadhyay,H.Fu,X.Cheng

Key ref:

J.Zhao et al. (2011). Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl Acad Sci U S A, 108, 16212-16216. PubMed id: 21908710

Date:

01-Apr-11 Release date: 28-Sep-11

Protein chains

P63104  (1433Z_HUMAN) -  14-3-3 protein zeta/delta from Homo sapiens

Seq: 245 a.a.

Struc: 233 a.a.

Proc Natl Acad Sci U S A 108:16212-16216 (2011)

PubMed id: 21908710

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.

J.Zhao, Y.Du, J.R.Horton, A.K.Upadhyay, B.Lou, Y.Bai, X.Zhang, L.Du, M.Li, B.Wang, L.Zhang, J.T.Barbieri, F.R.Khuri, X.Cheng, H.Fu.

ABSTRACT

No abstract given.