PDBsum entry 3o4z

Protein binding

PDB id

3o4z

Loading ...

Contents

			Protein chains

					572 a.a. *

* Residue conservation analysis

PDB id:

3o4z

Links

Name:

Protein binding

Title:

Tel2 structure and function in the hsp90-dependent maturation of mtor and atr complexes

Structure:

Telomere length regulation protein tel2. Chain: a, b, c, d. Engineered: yes

Source:

Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: tel2, ygr099w. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hi-5 insect cells

Resolution:

3.10Å

R-factor:

0.223

R-free:

0.239

Authors:

Y.Xie,N.P.Pavletich

Key ref:

H.Takai et al. (2010). Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev, 24, 2019-2030. PubMed id: 20801936

Date:

27-Jul-10

Release date:

15-Sep-10

PROCHECK

	Headers

	References

Protein chains

P53038 (TEL2_YEAST) - Telomere length regulation protein TEL2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: Struc:

Seq: Struc:					688 a.a. 572 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Genes Dev 24:2019-2030 (2010)
PubMed id: 20801936

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
H.Takai, Y.Xie, T.de Lange, N.P.Pavletich.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23263282

V.Fernández-Sáiz, B.S.Targosz, S.Lemeer, R.Eichner, C.Langer, L.Bullinger, C.Reiter, J.Slotta-Huspenina, S.Schroeder, A.M.Knorn, J.Kurutz, C.Peschel, M.Pagano, B.Kuster, and F.Bassermann (2013).
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

Nat Cell Biol, 15, 72-81.

20947357

R.L.Flynn, and L.Zou (2011).
ATR: a master conductor of cellular responses to DNA replication stress.

Trends Biochem Sci, 36, 133-140.

22068330

T.Glatter, R.B.Schittenhelm, O.Rinner, K.Roguska, A.Wepf, M.A.Jünger, K.Köhler, I.Jevtov, H.Choi, A.Schmidt, A.I.Nesvizhskii, H.Stocker, E.Hafen, R.Aebersold, and M.Gstaiger (2011).
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.

Mol Syst Biol, 7, 547.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.