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PDBsum entry 3o3c
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Glycogen synthase basal state udp complex
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Structure:
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Glycogen [starch] synthase isoform 2. Chain: a, b, c, d. Engineered: yes. Mutation: yes
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Source:
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Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: gsy2, ylr258w, l8479.8. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Resolution:
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3.51Å
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R-factor:
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0.221
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R-free:
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0.249
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Authors:
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S.Baskaran,T.D.Hurley
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Key ref:
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S.Baskaran
et al.
(2010).
Structural basis for glucose-6-phosphate activation of glycogen synthase.
Proc Natl Acad Sci U S A,
107,
17563-17568.
PubMed id:
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Date:
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23-Jul-10
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Release date:
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06-Oct-10
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PROCHECK
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Headers
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References
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P27472
(GYS2_YEAST) -
Glycogen [starch] synthase isoform 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
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Seq:
Struc:
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705 a.a.
611 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
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Enzyme class:
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E.C.2.4.1.11
- glycogen(starch) synthase.
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Pathway:
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Glycogen
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Reaction:
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[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D- glucosyl](n+1) + UDP + H+
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[(1->4)-alpha-D-glucosyl](n)
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+
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UDP-alpha-D-glucose
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=
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[(1->4)-alpha-D- glucosyl](n+1)
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+
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UDP
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+
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H(+)
Bound ligand (Het Group name = )
corresponds exactly
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Proc Natl Acad Sci U S A
107:17563-17568
(2010)
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PubMed id:
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Structural basis for glucose-6-phosphate activation of glycogen synthase.
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S.Baskaran,
P.J.Roach,
A.A.DePaoli-Roach,
T.D.Hurley.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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V.S.Tagliabracci,
C.Heiss,
C.Karthik,
C.J.Contreras,
J.Glushka,
M.Ishihara,
P.Azadi,
T.D.Hurley,
A.A.DePaoli-Roach,
and
P.J.Roach
(2011).
Phosphate incorporation during glycogen synthesis and Lafora disease.
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Cell Metab,
13,
274-282.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
