PDBsum entry 2ybe

Transferase

PDB id: 2ybe

Contents

Protein chain

410 a.a.

Ligands

LA8-ALF-3PG

Metals

_MG

_CL

Waters ×116

PDB id:

2ybe

Name:

Transferase

Title:

The structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride at 2.0 a resolution

Structure:

Phosphoglycerate kinase 1. Chain: a. Synonym: phosphoglycerate kinase, cell migration-inducing gene 10 protein, primer recognition protein 2, prp 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.00Å R-factor: 0.196 R-free: 0.243

Authors:

M.W.Bowler,L.Chaloin,C.Lionne

Key ref:

P.Lallemand et al. (2011). Interaction of human 3-phosphoglycerate kinase with its two substrates: is substrate antagonism a kinetic advantage? J Mol Biol, 409, 742-757. PubMed id: 21549713

Date:

07-Mar-11 Release date: 27-Apr-11

Protein chain

P00558  (PGK1_HUMAN) -  Phosphoglycerate kinase 1 from Homo sapiens

Seq: 417 a.a.

Struc: 410 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.2.3 - phosphoglycerate kinase.
• Pathway: Calvin Cycle (carbon fixation stages)
• Reaction: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP

(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP (Bound ligand (Het Group name = LA8) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

J Mol Biol 409:742-757 (2011)

PubMed id: 21549713

Interaction of human 3-phosphoglycerate kinase with its two substrates: is substrate antagonism a kinetic advantage?

P.Lallemand, L.Chaloin, B.Roy, T.Barman, M.W.Bowler, C.Lionne.

ABSTRACT

No abstract given.