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PDBsum entry 2xss

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protein Protein-protein interface(s) links
Hydrolase PDB id
2xss
Jmol
Contents
Protein chain
156 a.a.
PDB id:
2xss
Name: Hydrolase
Title: Crystal structure of gafb from the human phosphodiesterase 5
Structure: Cgmp-specific 3', 5'-cyclic phosphodiesterase. Chain: a, b. Fragment: gafb domain, residues 346-508. Synonym: cgmp-binding cgmp-specific phosphodiesterase, cgb- engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.50Å     R-factor:   0.251     R-free:   0.317
Authors: C.Schlicker,M.Russwurm,C.Steegborn
Key ref: M.Russwurm et al. (2011). Crystal structure of the GAF-B domain from human phosphodiesterase 5. Proteins, 79, 1682-1687. PubMed id: 21425347
Date:
30-Sep-10     Release date:   18-May-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
O76074  (PDE5A_HUMAN) -  cGMP-specific 3',5'-cyclic phosphodiesterase
Seq:
Struc:
 
Seq:
Struc:
875 a.a.
156 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.4.35  - 3',5'-cyclic-GMP phosphodiesterase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate
Guanosine 3',5'-cyclic phosphate
+ H(2)O
= guanosine 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
Proteins 79:1682-1687 (2011)
PubMed id: 21425347  
 
 
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
M.Russwurm, C.Schlicker, M.Weyand, D.Koesling, C.Steegborn.
 
  ABSTRACT  
 
No abstract given.