_EC 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase. 118 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.1.-.- Acting on ester bonds. [5,973 PDB entries]
EC 3.1.4.- Phosphoric diester hydrolases. [452 PDB entries]
EC 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase. [118 PDB entries]    
1fqj

Reaction: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
 


Guanosine 3',5'-cyclic phosphate
+ H(2)O
=
guanosine 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 118 PDB entries in enzyme class E.C.3.1.4.35

  PDB code Protein
1fqj
Crystal structure of the heterotrimeric complex of the rgs domain of rgs9, the gamma subunit of phosphodiesterase and the gt/i1 chimera alpha subunit [(rgs9)-(pdegamma)- (gt/i1alpha)-(gdp)-(alf4-)-(mg2+)]
Source: Bos taurus, rattus norvegicus. Cattle, norway rat. Organism_taxid: 9913,10116. Strain: ,. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
Chain: C (38 residues) CATH domain: 4.10.980.10
Bound ligand:   Het Group GDP is 44.00% similar to enzyme product nucleoside 5'-phosphate
1rkp
Crystal structure of pde5a1-ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5, pde5a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (311 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group IBM is 50.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
1t9r
Catalytic domain of human phosphodiesterase 5a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (301 residues) CATH domain: 1.10.1300.10
1t9s
Catalytic domain of human phosphodiesterase 5a in complex wi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 5GP corresponds to enzyme product guanosine
1tbf
Catalytic domain of human phosphodiesterase 5a in complex wi sildenafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (326 residues) CATH domain: 1.10.1300.10
1udt
Crystal structure of human phosphodiesterase 5 complexed with sildenafil(viagra)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (313 residues) CATH domain: 1.10.1300.10
1udu
Crystal structure of human phosphodiesterase 5 complexed with tadalafil(cialis)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (313 residues) CATH domain: 1.10.1300.10
1uho
Crystal structure of human phosphodiesterase 5 complexed with vardenafil(levitra)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (313 residues) CATH domain: 1.10.1300.10
1xoz
Catalytic domain of human phosphodiesterase 5a in complex with tadalafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (326 residues) CATH domain: 1.10.1300.10
1xp0
Catalytic domain of human phosphodiesterase 5a in complex wi vardenafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (326 residues) CATH domain: 1.10.1300.10
2chm
Crystal structure of n2 substituted pyrazolo pyrimidinones- a flipped binding mode in pde5
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chain: A (323 residues) CATH domain: 1.10.1300.10
2h40
Crystal structure of the catalytic domain of unliganded pde5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (311 residues) CATH domain: 1.10.1300.10
2h42
Crystal structure of pde5 in complex with sildenafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (326 residues) CATH domain: 1.10.1300.10
2h44
Crystal structure of pde5a1 in complex with icarisid ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (326 residues) CATH domain: 1.10.1300.10
2hd1
Crystal structure of pde9 in complex with ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group IBM is 50.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
2ju4
Nmr structure of the gamma subunit of cgmp phosphodiesterase
Source: Bos taurus. Cattle. Organism_taxid: 9913. Tissue: retina. Gene: pde6g, pdeg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (87 residues) CATH domain: 4.10.1120.10
Bound ligand:   Het Group RCY is 42.86% similar to enzyme reactant Guanosine
2k31
Solution structure of cgmp-binding gaf domain of phosphodiesterase 5
Source: Mus musculus. Mouse. Gene: pde5a. Expressed in: escherichia coli.
Chain: A (149 residues) CATH domain: 3.30.450.40
Bound ligand:   Het Group 35G corresponds to enzyme reactant Guanosine 3',5'-cyclic phosphate
2o8h
Crystal structure of the catalytic domain of rat phosphodiesterase 10a
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pde10a, pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (307 residues) CATH domain: 1.10.1300.10
2oun
Crystal structure of pde10a2 in complex with amp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group AMP is 95.00% similar to enzyme product guanosine 5'-phosphate
2oup
Crystal structure of pde10a
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
2ouq
Crystal structure of pde10a2 in complex with gmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 5GP corresponds to enzyme product guanosine 5'-phosphate
2our
Crystal structure of pde10a2 mutant d674a in complex with camp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group CMP is 95.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
2ous
Crystal structure of pde10a2 mutant d674a
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
2ouu
Crystal structure of pde10a2 mutant d674a in complex with cgmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (329 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 35G corresponds to enzyme reactant Guanosine 3',5'-cyclic phosphate
2ouv
Crystal structure of pde10a2 mutant of d564n
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (325 residues) CATH domain: 1.10.1300.10
2ouy
Crystal structure of pde10a2 mutant d564a in complex with camp.
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pde10a2. Gene: pde10a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group CMP is 95.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
2ovv
Crystal structure of the catalytic domain of rat phosphodies
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pde10a, pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (304 residues) CATH domain: 1.10.1300.10
2ovy
Crystal structure of the catalytic domain of rat phosphodies
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pde10a, pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
2wey
Human pde-papaverine complex obtained by ligand soaking of cross-linked protein crystals
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
2xss
Crystal structure of gafb from the human phosphodiesterase 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (156 residues) CATH domain: Unassigned
2y0j
Triazoloquinazolines as a novel class of phosphodiesterase 1 (pde10a) inhibitors, part 2, lead-optimisation.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (314 residues)
2yy2
Crystal structure of the human phosphodiesterase 9a catalytic domain complexed with ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: e. Coli cell free system
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group IBM is 50.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
2zmf
Crystal structure of thE C-terminal gaf domain of human phosphodiesterase 10a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: cell free (escherichia coli).
Chains: A, B (177 residues) CATH domain: 3.30.450.40
Bound ligand:   Het Group CMP is 95.65% similar to enzyme reactant Guanosine
3b2r
Crystal structure of pde5a1 catalytic domain in complex with vardenafil
Source: Homo sapiens. Human. Gene: pde5a, pde5. Expressed in: escherichia coli.
Chains: A, B (297 residues) CATH domain: 1.10.1300.10
3bjc
Crystal structure of the pde5a catalytic domain in complex with a novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (311 residues) CATH domain: 1.10.1300.10
3dba
Crystal structure of the cgmp-bound gaf a domain from the photoreceptor phosphodiesterase 6c
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Strain: rhode island red. Gene: pde6c. Expressed in: escherichia coli.
Chains: A, B (171 residues) CATH domain: 3.30.450.40
Bound ligand:   Het Group 35G corresponds to enzyme reactant Guanosine
3dy8
Human phosphodiesterase 9 in complex with product 5'-gmp (e+
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 5GP corresponds to enzyme product guanosine
3dyl
Human phosphdiesterase 9 substrate complex (es complex)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group PCG corresponds to enzyme reactant Guanosine
3dyn
Human phosphodiestrase 9 in complex with cgmp (zn inhibited)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group PCG corresponds to enzyme reactant Guanosine
3dyq
Human phosphodiestrase 9 (inhibited by omitting divalent cat complex with cgmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group PCG corresponds to enzyme reactant Guanosine
3dys
Human phosphodiestrase-5'gmp complex (ep), produced by soaki 20mm cgmp+20 mm mncl2+20 mm mgcl2 for 2 hours, and flash-co liquid nitrogen temperature when substrate was still abudan
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 5GP corresponds to enzyme product guanosine
3hc8
Investigation of aminopyridiopyrazinones as pde5 inhibitors: evaluation of modifications to the central ring system.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5, pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Other_details: residues 658-682 from pde4
Chain: A (324 residues) CATH domain: 1.10.1300.10
3hdz
Identification, synthesis, and sar of amino substituted pyrido[3,2b]pryaziones as potent and selective pde5 inhibitors
Source: Homo sapiens. Organism_taxid: 9606. Gene: pde5a, pde5, pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Other_details: residues 658-682 from pde4
Chain: A (323 residues) CATH domain: 1.10.1300.10
3hqw
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues) CATH domain: 1.10.1300.10
3hqy
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
3hqz
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
3hr1
Discovery of novel inhibitors of pde10a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues) CATH domain: 1.10.1300.10
3jsi
Human phosphodiesterase 9 in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group WTC is 40.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
3jsw
Human pde9 in complex with selective inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
3jwq
Crystal structure of chimeric pde5/pde6 catalytic domain com with sildenafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5, pde6c, pdea2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (324 residues) CATH domain: 1.10.1300.10
3jwr
Crystal structure of chimeric pde5/pde6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (ibmx) and pde6 gamma-subunit inhibitory peptide 70-87.
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Human. Other_details: this sequence occurs naturally in humans.
Chains: A, B, C, D (323 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group IBM is 50.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
3k3e
Crystal structure of the pde9a catalytic domain in complex w bay73-6691
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a, pde9a2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (320 residues) CATH domain: 1.10.1300.10
3k3h
Crystal structure of the pde9a catalytic domain in complex w bay73-6691
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a, pde9a2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (321 residues) CATH domain: 1.10.1300.10
3lfv
Crystal structure of unliganded pde5a gaf domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a, pde5a1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (391 residues) CATH domains: Unassigned 3.30.450.40
3lxg
Crystal structure of rat phosphodiesterase 10a in complex wi web-3
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pde10a. Expressed in: baculovirus. Expression_system_taxid: 10469. Expression_system_cell: sf9 insect cells
Chain: A (308 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group Z73 is 48.00% similar to enzyme reactant Guanosine 3',5'-cyclic phosphate
3mf0
Crystal structure of pde5a gaf domain (89-518)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a, pde5a1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (378 residues) CATH domains: Unassigned 3.30.450.40
3n3z
Crystal structure of pde9a (e406a) mutant in complex with ib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group IBM is 50.00% similar to enzyme reactant Guanosine
3qi3
Crystal structure of pde9a(q453e) in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde, pde9a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (325 residues) CATH domain: 1.10.1300.10
3qi4
Crystal structure of pde9a(q453e) in complex with ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (325 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group IBM is 50.00% similar to enzyme reactant Guanosine
3qpn
Structure of pde10-inhibitor complex
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (305 residues) CATH domain: 1.10.1300.10
3qpo
Structure of pde10-inhibitor complex
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (305 residues) CATH domain: 1.10.1300.10
3qpp
Structure of pde10-inhibitor complex
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (305 residues) CATH domain: 1.10.1300.10
3shy
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domain: 1.10.1300.10
3shz
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (297 residues) CATH domain: 1.10.1300.10
3sie
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (297 residues) CATH domain: 1.10.1300.10
3sn7
Highly potent, selective, and orally active phosphodiestaras inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 540 is 41.18% similar to enzyme reactant Guanosine
3sni
Highly potent, selective, and orally active phosphodiestaras inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 546 is 42.42% similar to enzyme reactant Guanosine
3snl
Highly potent, selective, and orally active phosphodiestaras inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
3tge
A novel series of potent and selective pde5 inhibitor1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (324 residues) CATH domain: 1.10.1300.10
3tgg
A novel series of potent and selective pde5 inhibitor2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (324 residues) CATH domain: 1.10.1300.10
3tse
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (297 residues) CATH domain: 1.10.1300.10
3tsf
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues) CATH domain: 1.10.1300.10
3ui7
Discovery of orally active pyrazoloquinoline as a potent pde inhibitor for the management of schizophrenia
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (315 residues) CATH domain: 1.10.1300.10
3uuo
The discovery of potent, selectivity, and orally bioavailabl pyrozoloquinolines as pde10 inhibitors for the treatment of schizophrenia
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (305 residues) CATH domain: 1.10.1300.10
3wi2
Crystal structure of pde10a in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
3ws8
Crystal structure of pde10a in complex with a benzimidazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
3ws9
Crystal structure of pde10a in complex with a benzimdazole i
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (324 residues) CATH domain: 1.10.1300.10
4ael
Pde10a in complex with the inhibitor az5
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (320 residues) CATH domain: 1.10.1300.10
4ajd
Identification and structural characterization of pde10 fragment inhibitors
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (324 residues) CATH domain: 1.10.1300.10
4ajf
Identification and structural characterization of pde10 fragment inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (328 residues) CATH domain: 1.10.1300.10
4ajg
Identification and structural characterization of pde10 fragment inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (321 residues) CATH domain: 1.10.1300.10
4ajm
Development of a plate-based optical biosensor methodology to identify pde10 fragment inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, D (320 residues) CATH domain: 1.10.1300.10
4bbx
Discovery of a potent, selective and orally active pde10a inhibitor for the treatment of schizophrenia
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (312 residues) CATH domain: 1.10.1300.10
4ddl
Pde10a crystal structure complexed with novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4dff
The sar development of dihydroimidazoisoquinoline derivative phosphodiesterase 10a inhibitors for the treatment of schiz
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (307 residues) CATH domain: 1.10.1300.10
4e90
Human phosphodiesterase 9 in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4fcb
Potent and selective phosphodiesterase 10a inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
4fcd
Potent and selective phosphodiesterase 10a inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 0T6 is 45.45% similar to enzyme reactant Guanosine
4g2j
Human pde9 in complex with selective compound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4g2l
Human pde9 in complex with selective compound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4g2w
Crystal structure of pde5a in complex with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues) CATH domain: 1.10.1300.10
4g2y
Crystal structure of pde5a complexed with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (297 residues) CATH domain: 1.10.1300.10
4gh6
Crystal structure of the pde9a catalytic domain in complex w inhibitor 28
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde9a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
4heu
Crystal structure of pde10a with a biaryl ether inhibitor (( ((1h-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piper yl)methanol)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4hf4
Crystal structure of pde10a with a biaryl ether inhibitor (1 (benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4 ethanol)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4i9z
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (296 residues) CATH domain: 1.10.1300.10
4ia0
Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Source: Homo sapiens. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (292 residues) CATH domain: 1.10.1300.10
4lkq
Crystal structure of pde10a2 with fragment zt017
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4llj
Crystal structure of pde10a2 with fragment zt214
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (329 residues) CATH domain: 1.10.1300.10
4llk
Crystal structure of pde10a2 with fragment zt217
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group MEW is 45.83% similar to enzyme reactant Guanosine
4llp
Crystal structure of pde10a2 with fragment zt401
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4llx
Crystal structure of pde10a2 with fragment zt434
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4lm0
Crystal structure of pde10a2 with fragment zt448
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4lm1
Crystal structure of pde10a2 with fragment zt450
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (332 residues) CATH domain: 1.10.1300.10
4lm2
Crystal structure of pde10a2 with fragment zt462
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4lm3
Crystal structure of pde10a2 with fragment zt464
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (331 residues) CATH domain: 1.10.1300.10
4lm4
Crystal structure of pde10a2 with fragment zt902
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group JPZ is 41.67% similar to enzyme reactant Guanosine
4md6
Crystal structure of pde5 in complex with inhibitor 5r
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (299 residues) CATH domain: 1.10.1300.10
4mrw
Crystal structure of pde10a2 with fragment zt0120 (7-chloroq ol)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4mrz
Crystal structure of pde10a2 with fragment zt0429 (4-methyl- nitropyridin-2-amine)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4ms0
Crystal structure of pde10a2 with fragment zt0443 (6-chlorop 2,4-diamine)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4msa
Crystal structure of pde10a2 with fragment zt0449 (5-nitro-1 benzimidazole)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4msc
Crystal structure of pde10a2 with fragment zt1595 (2-[(quino yloxy)methyl]quinoline)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4mse
Crystal structure of pde10a2 with fragment zt1597 (2-({[(2s) 2,3-dihydro-1,3-benzothiazol-5-yl]oxy}methyl)quinoline)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4msh
Crystal structure of pde10a2 with fragment zt0143 ((2s)-4-ch dihydro-1,3-benzothiazol-2-amine)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (328 residues) CATH domain: 1.10.1300.10
4msn
Crystal structure of pde10a2 with fragment zt0451 (8-nitroqu
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (330 residues) CATH domain: 1.10.1300.10
4muw
Crystal structure of pde10a with novel keto-benzimidazole in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (318 residues) CATH domain: 1.10.1300.10
4mvh
Crystal structure of pde10a with novel keto-benzimidazole in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (307 residues) CATH domain: 1.10.1300.10