PDBsum entry: 2f7f

Transferase

PDB id: 2f7f

Contents

Protein chain

482 a.a. *

Ligands

SO4 ×8

NIO ×2

DPO

GOL

Waters ×390

* Residue conservation analysis

PDB id:

2f7f

Name:

Transferase

Title:

Crystal structure of enterococcus faecalis putative nicotina phosphoribosyltransferase, new york structural genomics con

Structure:

Nicotinate phosphoribosyltransferase, putative. Chain: a. Engineered: yes

Source:

Enterococcus faecalis. Organism_taxid: 226185. Strain: v583. Gene: ef2626. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Tetramer (from PDB file)

Resolution:

2.00Å R-factor: 0.172 R-free: 0.214

Authors:

Y.Patskovsky,S.C.Almo,S.K.Burley,New York Sgx Research Cente Structural Genomics (Nysgxrc)

Key ref:

Y.Patskovsky and s.c.almo Crystal structure of enterococcus faecalis nicotinate phosphoribosyltransferase. To be published,

Date:

30-Nov-05 Release date: 13-Dec-05

Protein chain

Q830Y8  (Q830Y8_ENTFA) -  Nicotinate phosphoribosyltransferase

Seq: 494 a.a.

Struc: 482 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.4.2.11 - Nicotinate phosphoribosyltransferase.
• Reaction: Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha- D-ribose 1-diphosphate

Nicotinate D-ribonucleotide + diphosphate (Bound ligand (Het Group name = DPO) corresponds exactly) = nicotinate (Bound ligand (Het Group name = NIO) corresponds exactly) + 5-phospho-alpha- D-ribose 1-diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (1 term)
• Biological process: pyridine nucleotide biosynthetic process (3 terms)
• Biochemical function: transferase activity (4 terms)