PDBsum entry 1vk6

Hydrolase

PDB id

1vk6

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Contents

			Protein chain

					257 a.a. *

			Ligands

					MPD ×3

			Metals

					_ZN

			Waters ×96

* Residue conservation analysis

PDB id:

1vk6

Links

Name:

Hydrolase

Title:

Crystal structure of nadh pyrophosphatase (1790429) from escherichia coli k12 at 2.20 a resolution

Structure:

Nadh pyrophosphatase. Chain: a. Engineered: yes

Source:

Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: nudc, b3996. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.20Å

R-factor:

0.188

R-free:

0.220

Authors:

Joint Center For Structural Genomics (Jcsg)

Key ref:

Joint center for structural genomics (jcsg) Crystal structure of nadh pyrophosphatase (1790429) from escherichia coli k12 at 2.20 a resolution. To be published, .

Date:

30-Apr-04

Release date:

11-May-04

PROCHECK

	Headers

	References

Protein chain

P32664 (NUDC_ECOLI) - NAD-capped RNA hydrolase NudC from Escherichia coli (strain K12)

Seq: Struc:					257 a.a. 257 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class 2:

E.C.3.6.1.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Enzyme class 3:

E.C.3.6.1.22 - NAD(+) diphosphatase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

1.	NAD⁺ + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H⁺
2.	NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H⁺

NAD(+)	+	H2O	=	beta-nicotinamide D-ribonucleotide	+	AMP	+	2 × H(+)

NADH	+	H2O	=	reduced beta-nicotinamide D-ribonucleotide	+	AMP	+	2 × H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site