PDBsum entry 1tpy

Transferase

PDB id: 1tpy

Contents

Protein chain

285 a.a. *

Ligands

CO3

SAH

16A

Waters ×192

* Residue conservation analysis

PDB id:

1tpy

Name:

Transferase

Title:

Structure of the cyclopropane synthase mmaa2 from mycobacterium tuberculosis

Structure:

Methoxy mycolic acid synthase 2. Chain: a. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mmaa2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.20Å R-factor: 0.194 R-free: 0.232

Authors:

C.V.Smith,J.C.Sacchettini

Key ref:

C.V.Smith and j.c.sacchettini Structure of the cyclopropane synthase mmaa2 from mycobacterium tuberculosis. To be published, .

Date:

16-Jun-04 Release date: 19-Oct-04

Protein chain

Q79FX6  (MMAA2_MYCTU) -  Cyclopropane mycolic acid synthase MmaA2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 287 a.a.

Struc: 285 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.79 - cyclopropane-fatty-acyl-phospholipid synthase.
• Reaction: a 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = a 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + S-adenosyl-L-homocysteine + H⁺

1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + S-adenosyl-L-homocysteine + H(+) (Bound ligand (Het Group name = SAH) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site