_EC 2.1.1.79 Cyclopropane-fatty-acyl-phospholipid synthase. 7 PDB entries  
EC 2.-.-.- Transferases. [16,521 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,566 PDB entries]
EC 2.1.1.- Methyltransferases. [1,227 PDB entries]
EC 2.1.1.79 Cyclopropane-fatty-acyl-phospholipid synthase. [7 PDB entries]    
1kp9

Reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid.
 


S-adenosyl-L-methionine
+
phospholipid olefinic fatty acid
=
S-adenosyl- L-homocysteine
+
phospholipid cyclopropane fatty acid
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Cfa synthase. Cyclopropane fatty acid synthase. Cyclopropane synthetase. Unsaturated-phospholipid methyltransferase.
Comments: Adds a methylene group across the 9,10 position of a Delta(9)- olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol forming a cyclopropane derivative (cf. Ec 2.1.1.16).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.2.1.1.79

  PDB code Protein
1kp9
Crystal structure of mycolic acid cyclopropane synthase cmaa1, apo-form
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: cmaa1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (270 residues) CATH domain: 3.40.50.150
1kpg
Crystal structure of mycolic acid cyclopropane synthase cmaa1 complexed with sah and ctab
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: cmaa1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (285 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosyl-L-methionine
1kph
Crystal structure of mycolic acid cyclopropane synthase cmaa1 complexed with sah and dddmab
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: cmaa1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (283 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH is 56.00% similar to enzyme product S-adenosyl-L-methionine
1kpi
Crystal structure of mycolic acid cyclopropane synthase cmaa complexed with sah and dddmab
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: cmaa2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosyl-L-methionine
1l1e
Crystal structure of mycolic acid cyclopropane synthase pcaa complexed with s-adenosyl-l-homocysteine
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: pcaa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (272 residues) CATH domain: 3.40.50.150
1tpy
Structure of the cyclopropane synthase mmaa2 from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mmaa2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (285 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
3hem
Structure of mycobacterium tuberculosis mycolic acid cyclopropane synthase cmaa2 in complex with dioctylamine
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: cma2, cmaa2, mt0524, mtcy20g9.30c, rv0503c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (291 residues) CATH domain: 3.40.50.150