|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transcription/DNA
|
|
|
Title:
|
|
Two human c-fos:c-jun:dna complexes
|
|
Structure:
|
|
DNA (5'- d( Ap Ap Tp Gp Gp Ap Tp Gp Ap Gp Tp Cp Ap Tp Ap Gp Gp Ap Gp A)-3'). Chain: a, c. Engineered: yes. DNA (5'- d( Tp Tp Cp Tp Cp Cp Tp Ap Tp Gp Ap Cp Tp Cp Ap Tp Cp Cp Ap T)-3'). Chain: b, d.
|
|
Source:
|
|
Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Biol. unit:
|
|
Dimer (from
)
|
|
Resolution:
|
|
|
3.05Å
|
R-factor:
|
0.230
|
R-free:
|
0.321
|
|
|
Authors:
|
|
J.N.M.Glover,S.C.Harrison
|
|
Key ref:
|
|
J.N.Glover
and
S.C.Harrison
(1995).
Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.
Nature,
373,
257-261.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
07-Mar-95
|
Release date:
|
10-Jul-95
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
P01100
(FOS_HUMAN) -
Proto-oncogene c-Fos
|
|
|
|
Seq:
Struc:
|
|
|
|
380 a.a.
60 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gene Ontology (GO) functional annotation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cellular component
|
nucleus
|
1 term
|
|
|
Biological process
|
regulation of transcription, DNA-dependent
|
1 term
|
|
|
Biochemical function
|
DNA binding
|
4 terms
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Nature
373:257-261
(1995)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.
|
|
J.N.Glover,
S.C.Harrison.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
The Fos and Jun families of eukaryotic transcription factors heterodimerize to
form complexes capable of binding 5'-TGAGTCA-3' DNA elements. We have determined
the X-ray crystal structure of a heterodimer of the bZIP regions of c-Fos and
c-Jun bound to DNA. Both subunits form continuous alpha-helices. The
carboxy-terminal regions form an asymmetric coiled-coil, and the amino-terminal
regions make base-specific contacts with DNA in the major groove. Comparison of
the two crystallographically distinct protein-DNA complexes show that the
coiled-coil is flexibly joined to the basic regions and that the Fos-Jun
heterodimer does not recognize the asymmetric 5'-TGAGTCA-3' recognition element
in a unique orientation. There is an extensive network of electrostatic
interactions between subunits within the coiled-coil, consistent with proposals
that these interactions determine preferential formation of the heterodimer over
either of the homodimers.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.A.Worrall,
and
J.M.Mason
(2011).
Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists.
|
| |
FEBS J, 278,
663-672.
|
|
|
|
|
|
|
M.F.Maritz,
P.J.van der Watt,
N.Holderness,
M.J.Birrer,
and
V.D.Leaner
(2011).
Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression.
|
| |
Biol Chem, 392,
439-448.
|
|
|
|
|
|
|
T.S.Chen,
A.W.Reinke,
and
A.E.Keating
(2011).
Design of peptide inhibitors that bind the bZIP domain of Epstein-Barr virus protein BZLF1.
|
| |
J Mol Biol, 408,
304-320.
|
|
|
|
|
|
|
V.N.Uversky
(2011).
Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes.
|
| |
Chem Soc Rev, 40,
1623-1634.
|
|
|
|
|
|
|
X.Li,
and
P.LuValle
(2011).
Activating transcription factor 2 targets c-Fos, but not c-Jun, in growth plate chondrocytes.
|
| |
J Cell Biochem, 112,
211-216.
|
|
|
|
|
|
|
B.Apostolovic,
M.Danial,
and
H.A.Klok
(2010).
Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials.
|
| |
Chem Soc Rev, 39,
3541-3575.
|
|
|
|
|
|
|
C.Rodrigues-Pousada,
R.A.Menezes,
and
C.Pimentel
(2010).
The Yap family and its role in stress response.
|
| |
Yeast, 27,
245-258.
|
|
|
|
|
|
|
J.Xu,
A.T.De Jong,
G.Chen,
H.K.Chow,
C.O.Damaso,
A.Schwartz Mittelman,
and
J.A.Shin
(2010).
Reengineering natural design by rational design and in vivo library selection: the HLH subdomain in bHLHZ proteins is a unique requirement for DNA-binding function.
|
| |
Protein Eng Des Sel, 23,
337-346.
|
|
|
|
|
|
|
K.L.Seldeen,
C.B.McDonald,
B.J.Deegan,
V.Bhat,
and
A.Farooq
(2010).
Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA.
|
| |
Biochem Biophys Res Commun, 394,
1030-1035.
|
|
|
|
|
|
|
M.Bergbauer,
M.Kalla,
A.Schmeinck,
C.Göbel,
U.Rothbauer,
S.Eck,
A.Benet-Pagès,
T.M.Strom,
and
W.Hammerschmidt
(2010).
CpG-methylation regulates a class of Epstein-Barr virus promoters.
|
| |
PLoS Pathog, 6,
0.
|
|
|
|
|
|
|
M.S.Almén,
J.A.Jacobsson,
J.H.Shaik,
P.K.Olszewski,
J.Cedernaes,
J.Alsiö,
S.Sreedharan,
A.S.Levine,
R.Fredriksson,
C.Marcus,
and
H.B.Schiöth
(2010).
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.
|
| |
BMC Med Genet, 11,
58.
|
|
|
|
|
|
|
R.St-Arnaud,
V.Mandic,
and
B.Elchaarani
(2010).
FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1.
|
| |
Ann N Y Acad Sci, 1192,
338-343.
|
|
|
|
|
|
|
A.Seidi,
M.Mie,
and
E.Kobatake
(2009).
Recombination system based on cre alpha complementation and leucine zipper fusions.
|
| |
Appl Biochem Biotechnol, 158,
334-342.
|
|
|
|
|
|
|
H.Kurokawa,
H.Motohashi,
S.Sueno,
M.Kimura,
H.Takagawa,
Y.Kanno,
M.Yamamoto,
and
T.Tanaka
(2009).
Structural basis of alternative DNA recognition by Maf transcription factors.
|
| |
Mol Cell Biol, 29,
6232-6244.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.L.Seldeen,
C.B.McDonald,
B.J.Deegan,
and
A.Farooq
(2009).
Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimeric transcription factor.
|
| |
Biochemistry, 48,
1975-1983.
|
|
|
|
|
|
|
K.L.Seldeen,
C.B.McDonald,
B.J.Deegan,
V.Bhat,
and
A.Farooq
(2009).
DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif.
|
| |
Biochemistry, 48,
12213-12222.
|
|
|
|
|
|
|
M.Miller
(2009).
The importance of being flexible: the case of basic region leucine zipper transcriptional regulators.
|
| |
Curr Protein Pept Sci, 10,
244-269.
|
|
|
|
|
|
|
O.Etxebeste,
E.Herrero-García,
L.Araújo-Bazán,
A.B.Rodríguez-Urra,
A.Garzia,
U.Ugalde,
and
E.A.Espeso
(2009).
The bZIP-type transcription factor FlbB regulates distinct morphogenetic stages of colony formation in Aspergillus nidulans.
|
| |
Mol Microbiol, 73,
775-789.
|
|
|
|
|
|
|
S.Lindert,
M.Silvestry,
T.M.Mullen,
G.R.Nemerow,
and
P.L.Stewart
(2009).
Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrin.
|
| |
J Virol, 83,
11491-11501.
|
|
|
|
|
|
|
W.L.Liu,
R.A.Coleman,
E.Ma,
P.Grob,
J.L.Yang,
Y.Zhang,
G.Dailey,
E.Nogales,
and
R.Tjian
(2009).
Structures of three distinct activator-TFIID complexes.
|
| |
Genes Dev, 23,
1510-1521.
|
|
|
|
|
|
|
Z.Yuan,
S.Gong,
J.Luo,
Z.Zheng,
B.Song,
S.Ma,
J.Guo,
C.Hu,
G.Thiel,
C.Vinson,
C.D.Hu,
Y.Wang,
and
M.Li
(2009).
Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis.
|
| |
Mol Cell Biol, 29,
2431-2442.
|
|
|
|
|
|
|
Z.Yuchi,
V.P.Pau,
B.X.Lu,
M.Junop,
and
D.S.Yang
(2009).
An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel.
|
| |
FEBS J, 276,
6236-6246.
|
|
|
|
|
|
|
B.Maggio,
G.A.Borioli,
M.Del Boca,
L.De Tullio,
M.L.Fanani,
R.G.Oliveira,
C.M.Rosetti,
and
N.Wilke
(2008).
Composition-driven surface domain structuring mediated by sphingolipids and membrane-active proteins. Above the nano- but under the micro-scale: mesoscopic biochemical/structural cross-talk in biomembranes.
|
| |
Cell Biochem Biophys, 50,
79.
|
|
|
|
|
|
|
C.T.Yu,
J.C.Wu,
M.C.Liao,
S.L.Hsu,
and
C.Y.Huang
(2008).
Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A.
|
| |
J Biomed Sci, 15,
79-87.
|
|
|
|
|
|
|
E.P.Lamber,
L.Vanhille,
L.C.Textor,
G.S.Kachalova,
M.H.Sieweke,
and
M.Wilmanns
(2008).
Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.
|
| |
EMBO J, 27,
2006-2017.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.Vámosi,
N.Baudendistel,
C.W.von der Lieth,
N.Szalóki,
G.Mocsár,
G.Müller,
P.Brázda,
W.Waldeck,
S.Damjanovich,
J.Langowski,
and
K.Tóth
(2008).
Conformation of the c-Fos/c-Jun complex in vivo: a combined FRET, FCCS, and MD-modeling study.
|
| |
Biophys J, 94,
2859-2868.
|
|
|
|
|
|
|
H.K.Chow,
J.Xu,
S.H.Shahravan,
A.T.De Jong,
G.Chen,
and
J.A.Shin
(2008).
Hybrids of the bHLH and bZIP protein motifs display different DNA-binding activities in vivo vs. in vitro.
|
| |
PLoS ONE, 3,
e3514.
|
|
|
|
|
|
|
K.L.Seldeen,
C.B.McDonald,
B.J.Deegan,
and
A.Farooq
(2008).
Evidence that the bZIP domains of the Jun transcription factor bind to DNA as monomers prior to folding and homodimerization.
|
| |
Arch Biochem Biophys, 480,
75-84.
|
|
|
|
|
|
|
N.A.Ciaccio,
M.L.Moreno,
R.L.Bauer,
and
J.S.Laurence
(2008).
High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5.
|
| |
Protein Expr Purif, 62,
235-243.
|
|
|
|
|
|
|
S.H.Fatemi,
T.J.Reutiman,
T.D.Folsom,
and
R.W.Sidwell
(2008).
The role of cerebellar genes in pathology of autism and schizophrenia.
|
| |
Cerebellum, 7,
279-294.
|
|
|
|
|
|
|
X.Y.Wang,
C.F.Song,
W.G.Miao,
Z.L.Ji,
X.Wang,
Y.Zhang,
J.H.Zhang,
J.S.Hu,
W.Borth,
and
J.S.Wang
(2008).
Mutations in the N-terminal coding region of the harpin protein Hpa1 from Xanthomonas oryzae cause loss of hypersensitive reaction induction in tobacco.
|
| |
Appl Microbiol Biotechnol, 81,
359-369.
|
|
|
|
|
|
|
Y.Aikawa,
K.Morimoto,
T.Yamamoto,
H.Chaki,
A.Hashiramoto,
H.Narita,
S.Hirono,
and
S.Shiozawa
(2008).
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1.
|
| |
Nat Biotechnol, 26,
817-823.
|
|
|
|
|
|
|
B.Grondin,
M.Lefrancois,
M.Tremblay,
M.Saint-Denis,
A.Haman,
K.Waga,
A.Bédard,
D.G.Tenen,
and
T.Hoang
(2007).
c-Jun homodimers can function as a context-specific coactivator.
|
| |
Mol Cell Biol, 27,
2919-2933.
|
|
|
|
|
|
|
C.Portela,
F.Albericio,
R.Eritja,
L.Castedo,
and
J.L.Mascareñas
(2007).
ds-Oligonucleotide-peptide conjugates featuring peptides from the leucine-zipper region of Fos as switchable receptors for the oncoprotein Jun.
|
| |
Chembiochem, 8,
1110-1114.
|
|
|
|
|
|
|
C.W.Lee,
S.H.Lee,
J.W.Lee,
J.O.Ban,
S.Y.Lee,
H.S.Yoo,
J.K.Jung,
D.C.Moon,
K.W.Oh,
and
J.T.Hong
(2007).
2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation.
|
| |
J Pharmacol Sci, 104,
19-28.
|
|
|
|
|
|
|
I.S.Chan,
A.V.Fedorova,
and
J.A.Shin
(2007).
The GCN4 bZIP targets noncognate gene regulatory sequences: quantitative investigation of binding at full and half sites.
|
| |
Biochemistry, 46,
1663-1671.
|
|
|
|
|
|
|
I.Waldmann,
S.Wälde,
and
R.H.Kehlenbach
(2007).
Nuclear import of c-Jun is mediated by multiple transport receptors.
|
| |
J Biol Chem, 282,
27685-27692.
|
|
|
|
|
|
|
J.M.Mason,
U.B.Hagemann,
and
K.M.Arndt
(2007).
Improved stability of the Jun-Fos Activator Protein-1 coiled coil motif: A stopped-flow circular dichroism kinetic analysis.
|
| |
J Biol Chem, 282,
23015-23024.
|
|
|
|
|
|
|
M.Ginsberg,
E.Czeko,
P.Müller,
Z.Ren,
X.Chen,
and
J.E.Darnell
(2007).
Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.
|
| |
Mol Cell Biol, 27,
6300-6308.
|
|
|
|
|
|
|
M.K.Yoon,
H.M.Kim,
G.Choi,
J.O.Lee,
and
B.S.Choi
(2007).
Structural basis for the conformational integrity of the Arabidopsis thaliana HY5 leucine zipper homodimer.
|
| |
J Biol Chem, 282,
12989-13002.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Kimura,
T.Yamamoto,
J.Zhang,
K.Itoh,
M.Kyo,
T.Kamiya,
H.Aburatani,
F.Katsuoka,
H.Kurokawa,
T.Tanaka,
H.Motohashi,
and
M.Yamamoto
(2007).
Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.
|
| |
J Biol Chem, 282,
33681-33690.
|
|
|
|
|
|
|
S.Neimanis,
W.Albig,
D.Doenecke,
and
J.Kahle
(2007).
Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport.
|
| |
J Biol Chem, 282,
35821-35830.
|
|
|
|
|
|
|
W.M.Matousek,
B.Ciani,
C.A.Fitch,
B.Garcia-Moreno,
R.A.Kammerer,
and
A.T.Alexandrescu
(2007).
Electrostatic contributions to the stability of the GCN4 leucine zipper structure.
|
| |
J Mol Biol, 374,
206-219.
|
|
|
|
|
|
|
A.V.Fedorova,
I.S.Chan,
and
J.A.Shin
(2006).
The GCN4 bZIP can bind to noncognate gene regulatory sequences.
|
| |
Biochim Biophys Acta, 1764,
1252-1259.
|
|
|
|
|
|
|
B.Miotto,
and
K.Struhl
(2006).
Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains.
|
| |
Mol Cell Biol, 26,
5969-5982.
|
|
|
|
|
|
|
C.Petosa,
P.Morand,
F.Baudin,
M.Moulin,
J.B.Artero,
and
C.W.Müller
(2006).
Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein.
|
| |
Mol Cell, 21,
565-572.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.Stuhlmann-Laeisz,
S.Lang,
A.Chalaris,
P.Krzysztof,
S.Enge,
J.Eichler,
U.Klingmüller,
M.Samuel,
M.Ernst,
S.Rose-John,
and
J.Scheller
(2006).
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.
|
| |
Mol Biol Cell, 17,
2986-2995.
|
|
|
|
|
|
|
L.Heston,
A.El-Guindy,
J.Countryman,
C.Dela Cruz,
H.J.Delecluse,
and
G.Miller
(2006).
Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication.
|
| |
J Virol, 80,
9115-9133.
|
|
|
|
|
|
|
P.Hivin,
C.Arpin-André,
I.Clerc,
B.Barbeau,
and
J.M.Mesnard
(2006).
A modified version of a Fos-associated cluster in HBZ affects Jun transcriptional potency.
|
| |
Nucleic Acids Res, 34,
2761-2772.
|
|
|
|
|
|
|
T.M.Madsen,
T.G.Bolwig,
and
J.D.Mikkelsen
(2006).
Differential regulation of c-Fos and FosB in the rat brain after amygdala kindling.
|
| |
Cell Mol Neurobiol, 26,
87.
|
|
|
|
|
|
|
W.M.Kazmierski,
T.P.Kenakin,
and
K.S.Gudmundsson
(2006).
Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4.
|
| |
Chem Biol Drug Des, 67,
13-26.
|
|
|
|
|
|
|
F.A.Blanco,
and
H.S.Judelson
(2005).
A bZIP transcription factor from Phytophthora interacts with a protein kinase and is required for zoospore motility and plant infection.
|
| |
Mol Microbiol, 56,
638-648.
|
|
|
|
|
|
|
J.A.Listman,
N.Wara-aswapati,
J.E.Race,
L.W.Blystone,
N.Walker-Kopp,
Z.Yang,
and
P.E.Auron
(2005).
Conserved ETS domain arginines mediate DNA binding, nuclear localization, and a novel mode of bZIP interaction.
|
| |
J Biol Chem, 280,
41421-41428.
|
|
|
|
|
|
|
P.M.Bhende,
W.T.Seaman,
H.J.Delecluse,
and
S.C.Kenney
(2005).
BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.
|
| |
J Virol, 79,
7338-7348.
|
|
|
|
|
|
|
S.W.Wu,
T.P.Ko,
C.C.Chou,
and
A.H.Wang
(2005).
Design and characterization of a multimeric DNA binding protein using Sac7d and GCN4 as templates.
|
| |
Proteins, 60,
617-628.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Zhang,
and
J.T.Barbieri
(2005).
A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells.
|
| |
Infect Immun, 73,
7938-7945.
|
|
|
|
|
|
|
D.A.Lindhout,
J.R.Litowski,
P.Mercier,
R.S.Hodges,
and
B.D.Sykes
(2004).
NMR solution structure of a highly stable de novo heterodimeric coiled-coil.
|
| |
Biopolymers, 75,
367-375.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.Coss,
S.B.Jacobs,
C.E.Bender,
and
P.L.Mellon
(2004).
A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone.
|
| |
J Biol Chem, 279,
152-162.
|
|
|
|
|
|
|
D.Panne,
T.Maniatis,
and
S.C.Harrison
(2004).
Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.
|
| |
EMBO J, 23,
4384-4393.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.A.Shin
(2004).
Minimalist proteins: Design of new molecular recognition scaffolds.
|
| |
Pure Appl Chem, 76,
1579-1590.
|
|
|
|
|
|
|
J.C.Sng,
H.Taniura,
and
Y.Yoneda
(2004).
A tale of early response genes.
|
| |
Biol Pharm Bull, 27,
606-612.
|
|
|
|
|
|
|
J.Dai,
C.Punchihewa,
P.Mistry,
A.T.Ooi,
and
D.Yang
(2004).
Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug.
|
| |
J Biol Chem, 279,
46096-46103.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.H.Fong,
A.E.Keating,
and
M.Singh
(2004).
Predicting specificity in bZIP coiled-coil protein interactions.
|
| |
Genome Biol, 5,
R11.
|
|
|
|
|
|
|
J.M.Mason,
and
K.M.Arndt
(2004).
Coiled coil domains: stability, specificity, and biological implications.
|
| |
Chembiochem, 5,
170-176.
|
|
|
|
|
|
|
M.J.Dubin,
P.H.Stokes,
E.Y.Sum,
R.S.Williams,
V.A.Valova,
P.J.Robinson,
G.J.Lindeman,
J.N.Glover,
J.E.Visvader,
and
J.M.Matthews
(2004).
Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.
|
| |
J Biol Chem, 279,
26932-26938.
|
|
|
|
|
|
|
N.Numao,
H.Fujii,
Y.Fukazawa,
N.Hanagata,
and
K.Tanaka
(2004).
Hydrophobic scale: a second parameter to elucidating various specific ligand-protein interactions.
|
| |
Chem Pharm Bull (Tokyo), 52,
377-379.
|
|
|
|
|
|
|
S.Park,
E.R.Hahm,
D.K.Lee,
and
C.H.Yang
(2004).
Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells.
|
| |
J Cell Biochem, 91,
973-986.
|
|
|
|
|
|
|
S.Z.Luo,
Y.M.Li,
W.Qiang,
Y.F.Zhao,
H.Abe,
T.Nemoto,
X.R.Qin,
and
H.Nakanishi
(2004).
Detection of specific noncovalent interaction of peptide with DNA by MALDI-TOF.
|
| |
J Am Soc Mass Spectrom, 15,
28-31.
|
|
|
|
|
|
|
T.N.Lively,
T.N.Nguyen,
S.K.Galasinski,
and
J.A.Goodrich
(2004).
The basic leucine zipper domain of c-Jun functions in transcriptional activation through interaction with the N terminus of human TATA-binding protein-associated factor-1 (human TAF(II)250).
|
| |
J Biol Chem, 279,
26257-26265.
|
|
|
|
|
|
|
A.Singh,
and
S.E.Hitchcock-DeGregori
(2003).
Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding.
|
| |
Biochemistry, 42,
14114-14121.
|
|
|
|
|
|
|
D.Pérez-Sala,
E.Cernuda-Morollón,
and
F.J.Cañada
(2003).
Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2.
|
| |
J Biol Chem, 278,
51251-51260.
|
|
|
|
|
|
|
E.Allahyarov,
H.Löwen,
and
G.Gompper
(2003).
Adsorption of monovalent and multivalent cations and anions on DNA molecules.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys, 68,
061903.
|
|
|
|
|
|
|
J.B.Mascarenhas,
M.A.Rüegg,
U.Winzen,
W.Halfter,
J.Engel,
and
J.Stetefeld
(2003).
Mapping of the laminin-binding site of the N-terminal agrin domain (NtA).
|
| |
EMBO J, 22,
529-536.
|
|
|
|
|
|
|
M.Miller,
J.D.Shuman,
T.Sebastian,
Z.Dauter,
and
P.F.Johnson
(2003).
Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha.
|
| |
J Biol Chem, 278,
15178-15184.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Eferl,
and
E.F.Wagner
(2003).
AP-1: a double-edged sword in tumorigenesis.
|
| |
Nat Rev Cancer, 3,
859-868.
|
|
|
|
|
|
|
R.Richie-Jannetta,
S.H.Francis,
and
J.D.Corbin
(2003).
Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.
|
| |
J Biol Chem, 278,
50070-50079.
|
|
|
|
|
|
|
R.W.Broadhurst,
D.Nietlispach,
M.P.Wheatcroft,
P.F.Leadlay,
and
K.J.Weissman
(2003).
The structure of docking domains in modular polyketide synthases.
|
| |
Chem Biol, 10,
723-731.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.A.Wolfe,
R.A.Grant,
and
C.O.Pabo
(2003).
Structure of a designed dimeric zinc finger protein bound to DNA.
|
| |
Biochemistry, 42,
13401-13409.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
V.Ramirez-Carrozzi,
and
T.Kerppola
(2003).
Asymmetric recognition of nonconsensus AP-1 sites by Fos-Jun and Jun-Jun influences transcriptional cooperativity with NFAT1.
|
| |
Mol Cell Biol, 23,
1737-1749.
|
|
|
|
|
|
|
Y.Yang,
L.Fanning,
and
T.Jack
(2003).
The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins, APETALA3 and PISTILLATA.
|
| |
Plant J, 33,
47-59.
|
|
|
|
|
|
|
A.S.El-Guindy,
L.Heston,
Y.Endo,
M.S.Cho,
and
G.Miller
(2002).
Disruption of Epstein-Barr virus latency in the absence of phosphorylation of ZEBRA by protein kinase C.
|
| |
J Virol, 76,
11199-11208.
|
|
|
|
|
|
|
C.D.Hu,
Y.Chinenov,
and
T.K.Kerppola
(2002).
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation.
|
| |
Mol Cell, 9,
789-798.
|
|
|
|
|
|
|
C.Vinson,
M.Myakishev,
A.Acharya,
A.A.Mir,
J.R.Moll,
and
M.Bonovich
(2002).
Classification of human B-ZIP proteins based on dimerization properties.
|
| |
Mol Cell Biol, 22,
6321-6335.
|
|
|
|
|
|
|
F.Briki,
J.Doucet,
and
C.Etchebest
(2002).
A procedure for refining a coiled coil protein structure using x-ray fiber diffraction and modeling.
|
| |
Biophys J, 83,
1774-1783.
|
|
|
|
|
|
|
G.H.Bird,
A.R.Lajmi,
and
J.A.Shin
(2002).
Sequence-specific recognition of DNA by hydrophobic, alanine-rich mutants of the basic region/leucine zipper motif investigated by fluorescence anisotropy.
|
| |
Biopolymers, 65,
10-20.
|
|
|
|
|
|
|
H.Kusunoki,
H.Motohashi,
F.Katsuoka,
A.Morohashi,
M.Yamamoto,
and
T.Tanaka
(2002).
Solution structure of the DNA-binding domain of MafG.
|
| |
Nat Struct Biol, 9,
252-256.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Fassler,
D.Landsman,
A.Acharya,
J.R.Moll,
M.Bonovich,
and
C.Vinson
(2002).
B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners.
|
| |
Genome Res, 12,
1190-1200.
|
|
|
|
|
|
|
J.P.Pursiheimo,
J.Saari,
M.Jalkanen,
and
M.Salmivirta
(2002).
Cooperation of protein kinase A and Ras/ERK signaling pathways is required for AP-1-mediated activation of fibroblast growth factor-inducible response element (FiRE).
|
| |
J Biol Chem, 277,
25344-25355.
|
|
|
|
|
|
|
J.R.Moll,
A.Acharya,
J.Gal,
A.A.Mir,
C.Vinson,
and
J.Gal
(2002).
Magnesium is required for specific DNA binding of the CREB B-ZIP domain.
|
| |
Nucleic Acids Res, 30,
1240-1246.
|
|
|
|
|
|
|
K.M.Campbell,
A.J.Sholders,
and
K.J.Lumb
(2002).
Contribution of buried lysine residues to the oligomerization specificity and stability of the fos coiled coil.
|
| |
Biochemistry, 41,
4866-4871.
|
|
|
|
|
|
|
L.Bakiri,
K.Matsuo,
M.Wisniewska,
E.F.Wagner,
and
M.Yaniv
(2002).
Promoter specificity and biological activity of tethered AP-1 dimers.
|
| |
Mol Cell Biol, 22,
4952-4964.
|
|
|
|
|
|
|
M.H.Godsey,
E.E.Zheleznova Heldwein,
and
R.G.Brennan
(2002).
Structural biology of bacterial multidrug resistance gene regulators.
|
| |
J Biol Chem, 277,
40169-40172.
|
|
|
|
|
|
|
P.K.Vogt
(2002).
Fortuitous convergences: the beginnings of JUN.
|
| |
Nat Rev Cancer, 2,
465-469.
|
|
|
|
|
|
|
P.R.Hardwidge,
J.Wu,
S.L.Williams,
K.M.Parkhurst,
L.J.Parkhurst,
and
L.J.Maher
(2002).
DNA bending by bZIP charge variants: a unified study using electrophoretic phasing and fluorescence resonance energy transfer.
|
| |
Biochemistry, 41,
7732-7742.
|
|
|
|
|
|
|
P.S.Renshaw,
P.Panagiotidou,
A.Whelan,
S.V.Gordon,
R.G.Hewinson,
R.A.Williamson,
and
M.D.Carr
(2002).
Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence.
|
| |
J Biol Chem, 277,
21598-21603.
|
|
|
|
|
|
|
R.I.Boysen,
A.J.Jong,
J.A.Wilce,
G.F.King,
and
M.T.Hearn
(2002).
Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun.
|
| |
J Biol Chem, 277,
23-31.
|
|
|
|
|
|
|
T.Ahrens,
O.Pertz,
D.Haussinger,
C.Fauser,
T.Schulthess,
and
J.Engel
(2002).
Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains.
|
| |
J Biol Chem, 277,
19455-19460.
|
|
|
|
|
|
|
U.Narendra,
L.Zhu,
B.Li,
J.Wilken,
and
M.A.Weiss
(2002).
Sex-specific gene regulation. The Doublesex DM motif is a bipartite DNA-binding domain.
|
| |
J Biol Chem, 277,
43463-43473.
|
|
|
|
|
|
|
Y.Li,
S.Mui,
J.H.Brown,
J.Strand,
L.Reshetnikova,
L.S.Tobacman,
and
C.Cohen
(2002).
The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site.
|
| |
Proc Natl Acad Sci U S A, 99,
7378-7383.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.J.DaFonseca,
F.Shu,
and
J.J.Zhang
(2001).
Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.
|
| |
Proc Natl Acad Sci U S A, 98,
3034-3039.
|
|
|
|
|
|
|
C.Jain,
and
J.G.Belasco
(2001).
Structural model for the cooperative assembly of HIV-1 Rev multimers on the RRE as deduced from analysis of assembly-defective mutants.
|
| |
Mol Cell, 7,
603-614.
|
|
|
|
|
|
|
J.J.Kohler,
and
A.Schepartz
(2001).
Kinetic studies of Fos.Jun.DNA complex formation: DNA binding prior to dimerization.
|
| |
Biochemistry, 40,
130-142.
|
|
|
|
|
|
|
J.K.Montclare,
L.S.Sloan,
and
A.Schepartz
(2001).
Electrostatic control of half-site spacing preferences by the cyclic AMP response element-binding protein CREB.
|
| |
Nucleic Acids Res, 29,
3311-3319.
|
|
|
|
|
|
|
M.Dlakić,
A.V.Grinberg,
D.A.Leonard,
and
T.K.Kerppola
(2001).
DNA sequence-dependent folding determines the divergence in binding specificities between Maf and other bZIP proteins.
|
| |
EMBO J, 20,
828-840.
|
|
|
|
|
|
|
M.Rep,
M.Proft,
F.Remize,
M.Tamás,
R.Serrano,
J.M.Thevelein,
and
S.Hohmann
(2001).
The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage.
|
| |
Mol Microbiol, 40,
1067-1083.
|
|
|
|
|
|
|
R.G.Vries,
M.Prudenziati,
C.Zwartjes,
M.Verlaan,
E.Kalkhoven,
and
A.Zantema
(2001).
A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.
|
| |
EMBO J, 20,
6095-6103.
|
|
|
|
|
|
|
T.H.Tahirov,
T.Inoue-Bungo,
H.Morii,
A.Fujikawa,
M.Sasaki,
K.Kimura,
M.Shiina,
K.Sato,
T.Kumasaka,
M.Yamamoto,
S.Ishii,
and
K.Ogata
(2001).
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.
|
| |
Cell, 104,
755-767.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.L.Schneider,
and
A.Schepartz
(2001).
Hepatitis B virus protein pX enhances the monomer assembly pathway of bZIP.DNA complexes.
|
| |
Biochemistry, 40,
2835-2843.
|
|
|
|
|
|
|
V.R.Ramirez-Carrozzi,
and
T.K.Kerppola
(2001).
Dynamics of Fos-Jun-NFAT1 complexes.
|
| |
Proc Natl Acad Sci U S A, 98,
4893-4898.
|
|
|
|
|
|
|
Y.Sibéril,
P.Doireau,
and
P.Gantet
(2001).
Plant bZIP G-box binding factors. Modular structure and activation mechanisms.
|
| |
Eur J Biochem, 268,
5655-5666.
|
|
|
|
|
|
|
C.Castagné,
H.Terenzi,
M.M.Zakin,
and
M.Delepierre
(2000).
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*.
|
| |
Biochimie, 82,
739-748.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.A.Erlanson
(2000).
The advantages of ambiguous orientation.
|
| |
Chem Biol, 7,
R81-R84.
|
|
|
|
|
|
|
D.N.Marti,
I.Jelesarov,
and
H.R.Bosshard
(2000).
Interhelical ion pairing in coiled coils: solution structure of a heterodimeric leucine zipper and determination of pKa values of Glu side chains.
|
| |
Biochemistry, 39,
12804-12818.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.Macián,
C.García-Rodríguez,
and
A.Rao
(2000).
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun.
|
| |
EMBO J, 19,
4783-4795.
|
|
|
|
|
|
|
K.B.Ellwood,
Y.M.Yen,
R.C.Johnson,
and
M.Carey
(2000).
Mechanism for specificity by HMG-1 in enhanceosome assembly.
|
| |
Mol Cell Biol, 20,
4359-4370.
|
|
|
|
|
|
|
L.D.Williams,
and
L.J.Maher
(2000).
Electrostatic mechanisms of DNA deformation.
|
| |
Annu Rev Biophys Biomol Struct, 29,
497-521.
|
|
|
|
|
|
|
L.Zhu,
J.Wilken,
N.B.Phillips,
U.Narendra,
G.Chan,
S.M.Stratton,
S.B.Kent,
and
M.A.Weiss
(2000).
Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.
|
| |
Genes Dev, 14,
1750-1764.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
N.C.Horton,
and
J.J.Perona
(2000).
Crystallographic snapshots along a protein-induced DNA-bending pathway.
|
| |
Proc Natl Acad Sci U S A, 97,
5729-5734.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.Burkhard,
R.A.Kammerer,
M.O.Steinmetz,
G.P.Bourenkov,
and
U.Aebi
(2000).
The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges.
|
| |
Structure, 8,
223-230.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.Mallick,
K.E.Goodwill,
S.Fitz-Gibbon,
J.H.Miller,
and
D.Eisenberg
(2000).
Selecting protein targets for structural genomics of Pyrobaculum aerophilum: validating automated fold assignment methods by using binary hypothesis testing.
|
| |
Proc Natl Acad Sci U S A, 97,
2450-2455.
|
|
|
|
|
|
|
S.Kumar,
and
R.Nussinov
(2000).
Fluctuations between stabilizing and destabilizing electrostatic contributions of ion pairs in conformers of the c-Myc-Max leucine zipper.
|
| |
Proteins, 41,
485-497.
|
|
|
|
|
|
|
S.N.Behncken,
N.Billestrup,
R.Brown,
J.Amstrup,
B.Conway-Campbell,
and
M.J.Waters
(2000).
Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation.
|
| |
J Biol Chem, 275,
17000-17007.
|
|
|
|
|
|
|
A.Boss,
A.Nussbaum-Shochat,
and
O.Amster-Choder
(1999).
Characterization of the dimerization domain in BglG, an RNA-binding transcriptional antiterminator from Escherichia coli.
|
| |
J Bacteriol, 181,
1755-1766.
|
|
|
|
|
|
|
A.Francis,
T.Ragoczy,
L.Gradoville,
L.Heston,
A.El-Guindy,
Y.Endo,
and
G.Miller
(1999).
Amino acid substitutions reveal distinct functions of serine 186 of the ZEBRA protein in activation of early lytic cycle genes and synergy with the Epstein-Barr virus R transactivator.
|
| |
J Virol, 73,
4543-4551.
|
|
|
|
|
|
|
A.M.Fry,
L.Arnaud,
and
E.A.Nigg
(1999).
Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif.
|
| |
J Biol Chem, 274,
16304-16310.
|
|
|
|
|
|
|
B.E.Willcox,
G.F.Gao,
J.R.Wyer,
C.A.O'Callaghan,
J.M.Boulter,
E.Y.Jones,
P.A.van der Merwe,
J.I.Bell,
and
B.K.Jakobsen
(1999).
Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.
|
| |
Protein Sci, 8,
2418-2423.
|
|
|
|
|
|
|
C.Wolberger
(1999).
Multiprotein-DNA complexes in transcriptional regulation.
|
| |
Annu Rev Biophys Biomol Struct, 28,
29-56.
|
|
|
|
|
|
|
J.D.Tyndall,
and
D.P.Fairlie
(1999).
Conformational homogeneity in molecular recognition by proteolytic enzymes.
|
| |
J Mol Recognit, 12,
363-370.
|
|
|
|
|
|
|
K.Nadassy,
S.J.Wodak,
and
J.Janin
(1999).
Structural features of protein-nucleic acid recognition sites.
|
| |
Biochemistry, 38,
1999-2017.
|
|
|
|
|
|
|
K.Wagschal,
B.Tripet,
P.Lavigne,
C.Mant,
and
R.S.Hodges
(1999).
The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins.
|
| |
Protein Sci, 8,
2312-2329.
|
|
|
|
|
|
|
L.Chen,
A.Rao,
and
S.C.Harrison
(1999).
Signal integration by transcription-factor assemblies: interactions of NF-AT1 and AP-1 on the IL-2 promoter.
|
| |
Cold Spring Harb Symp Quant Biol, 64,
527-531.
|
|
|
|
|
|
|
L.Chen
(1999).
Combinatorial gene regulation by eukaryotic transcription factors.
|
| |
Curr Opin Struct Biol, 9,
48-55.
|
|
|
|
|
|
|
S.F.Lin,
D.R.Robinson,
G.Miller,
and
H.J.Kung
(1999).
Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.
|
| |
J Virol, 73,
1909-1917.
|
|
|
|
|
|
|
T.Mahmoudi,
and
B.Sarkar
(1999).
Addition of positively charged tripeptide to N-terminus of the Fos basic region leucine zipper domain: implications on DNA bending, affinity, and specificity.
|
| |
Biopolymers, 50,
273-286.
|
|
|
|
|
|
|
X.Zhang,
M.H.Wrzeszczynska,
C.M.Horvath,
and
J.E.Darnell
(1999).
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
|
| |
Mol Cell Biol, 19,
7138-7146.
|
|
|
|
|
|
|
Y.Aizawa,
Y.Sugiura,
and
T.Morii
(1999).
Comparison of the sequence-selective DNA binding by peptide dimers with covalent and noncovalent dimerization domains.
|
| |
Biochemistry, 38,
1626-1632.
|
|
|
|
|
|
|
Y.Fujii,
T.Shimizu,
M.Kusumoto,
Y.Kyogoku,
T.Taniguchi,
and
T.Hakoshima
(1999).
Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
|
| |
EMBO J, 18,
5028-5041.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Eggers,
G.Siemann,
R.Blume,
and
W.Knepel
(1998).
Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein.
|
| |
J Biol Chem, 273,
18499-18508.
|
|
|
|
|
|
|
A.H.Batchelor,
D.E.Piper,
F.C.de la Brousse,
S.L.McKnight,
and
C.Wolberger
(1998).
The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
|
| |
Science, 279,
1037-1041.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Sitlani,
and
D.M.Crothers
(1998).
DNA-binding domains of Fos and Jun do not induce DNA curvature: an investigation with solution and gel methods.
|
| |
Proc Natl Acad Sci U S A, 95,
1404-1409.
|
|
|
|
|
|
|
A.Travers
(1998).
Transcription: activation by cooperating conformations.
|
| |
Curr Biol, 8,
R616-R618.
|
|
|
|
|
|
|
A.V.Khokhlatchev,
B.Canagarajah,
J.Wilsbacher,
M.Robinson,
M.Atkinson,
E.Goldsmith,
and
M.H.Cobb
(1998).
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.
|
| |
Cell, 93,
605-615.
|
|
|
|
|
|
|
C.Wolberger
(1998).
Combinatorial transcription factors.
|
| |
Curr Opin Genet Dev, 8,
552-559.
|
|
|
|
|
|
|
D.A.Leonard,
and
T.K.Kerppola
(1998).
DNA bending determines Fos-Jun heterodimer orientation.
|
| |
Nat Struct Biol, 5,
877-881.
|
|
|
|
|
|
|
I.W.Leung,
and
N.Lassam
(1998).
Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3.
|
| |
J Biol Chem, 273,
32408-32415.
|
|
|
|
|
|
|
J.D.Klemm,
S.L.Schreiber,
and
G.R.Crabtree
(1998).
Dimerization as a regulatory mechanism in signal transduction.
|
| |
Annu Rev Immunol, 16,
569-592.
|
|
|
|
|
|
|
J.R.Lundblad,
R.P.Kwok,
M.E.Laurance,
M.S.Huang,
J.P.Richards,
R.G.Brennan,
and
R.H.Goodman
(1998).
The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove.
|
| |
J Biol Chem, 273,
19251-19259.
|
|
|
|
|
|
|
L.A.Tomky,
J.K.Strauss-Soukup,
and
L.J.Maher
(1998).
Effects of phosphate neutralization on the shape of the AP-1 transcription factor binding site in duplex DNA.
|
| |
Nucleic Acids Res, 26,
2298-2305.
|
|
|
|
|
|
|
L.S.Sloan,
and
A.Schepartz
(1998).
Sequence determinants of the intrinsic bend in the cyclic AMP response element.
|
| |
Biochemistry, 37,
7113-7118.
|
|
|
|
|
|
|
M.Baumann,
H.Mischak,
S.Dammeier,
W.Kolch,
O.Gires,
D.Pich,
R.Zeidler,
H.J.Delecluse,
and
W.Hammerschmidt
(1998).
Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation.
|
| |
J Virol, 72,
8105-8114.
|
|
|
|
|
|
|
M.Chytil,
B.R.Peterson,
D.A.Erlanson,
and
G.L.Verdine
(1998).
The orientation of the AP-1 heterodimer on DNA strongly affects transcriptional potency.
|
| |
Proc Natl Acad Sci U S A, 95,
14076-14081.
|
|
|
|
|
|
|
M.G.Oakley,
and
P.S.Kim
(1998).
A buried polar interaction can direct the relative orientation of helices in a coiled coil.
|
| |
Biochemistry, 37,
12603-12610.
|
|
|
|
|
|
|
M.K.Shirra,
and
U.Hansen
(1998).
LSF and NTF-1 share a conserved DNA recognition motif yet require different oligomerization states to form a stable protein-DNA complex.
|
| |
J Biol Chem, 273,
19260-19268.
|
|
|
|
|
|
|
P.Zhou,
L.J.Sun,
V.Dötsch,
G.Wagner,
and
G.L.Verdine
(1998).
Solution structure of the core NFATC1/DNA complex.
|
| |
Cell, 92,
687-696.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.J.Diebold,
N.Rajaram,
D.A.Leonard,
and
T.K.Kerppola
(1998).
Molecular basis of cooperative DNA bending and oriented heterodimer binding in the NFAT1-Fos-Jun-ARRE2 complex.
|
| |
Proc Natl Acad Sci U S A, 95,
7915-7920.
|
|
|
|
|
|
|
S.Huguier,
J.Baguet,
S.Perez,
H.van Dam,
and
M.Castellazzi
(1998).
Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo.
|
| |
Mol Cell Biol, 18,
7020-7029.
|
|
|
|
|
|
|
S.Yao,
M.Brickner,
E.I.Pares-Matos,
and
J.Chmielewski
(1998).
Uncoiling c-Jun coiled coils: inhibitory effects of truncated Fos peptides on Jun dimerization and DNA binding in vitro.
|
| |
Biopolymers, 47,
277-283.
|
|
|
|
|
|
|
T.K.Kerppola
(1998).
Transcriptional cooperativity: bending over backwards and doing the flip.
|
| |
Structure, 6,
549-554.
|
|
|
|
|
|
|
X.Wu,
C.Spiro,
W.G.Owen,
and
C.T.McMurray
(1998).
cAMP response element-binding protein monomers cooperatively assemble to form dimers on DNA.
|
| |
J Biol Chem, 273,
20820-20827.
|
|
|
|
|
|
|
Y.León,
C.Sanz,
F.Giráldez,
and
I.Varela-Nieto
(1998).
Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle.
|
| |
J Comp Neurol, 398,
323-332.
|
|
|
|
|
|
|
Y.Shi,
Y.F.Wang,
L.Jayaraman,
H.Yang,
J.Massagué,
and
N.P.Pavletich
(1998).
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
|
| |
Cell, 94,
585-594.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Tang,
F.Tie,
I.Boros,
R.Harrod,
M.Glover,
and
C.Z.Giam
(1998).
An extended alpha-helix and specific amino acid residues opposite the DNA-binding surface of the cAMP response element binding protein basic domain are important for human T cell lymphotropic retrovirus type I Tax binding.
|
| |
J Biol Chem, 273,
27339-27346.
|
|
|
|
|
|
|
A.L.Francis,
L.Gradoville,
and
G.Miller
(1997).
Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
|
| |
J Virol, 71,
3054-3061.
|
|
|
|
|
|
|
A.S.Carroll,
D.E.Gilbert,
X.Liu,
J.W.Cheung,
J.E.Michnowicz,
G.Wagner,
T.E.Ellenberger,
and
T.K.Blackwell
(1997).
SKN-1 domain folding and basic region monomer stabilization upon DNA binding.
|
| |
Genes Dev, 11,
2227-2238.
|
|
|
|
|
|
|
D.A.Leonard,
N.Rajaram,
and
T.K.Kerppola
(1997).
Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun.
|
| |
Proc Natl Acad Sci U S A, 94,
4913-4918.
|
|
|
|
|
|
|
D.Meierhans,
M.Sieber,
and
R.K.Allemann
(1997).
High affinity binding of MEF-2C correlates with DNA bending.
|
| |
Nucleic Acids Res, 25,
4537-4544.
|
|
|
|
|
|
|
D.N.Paolella,
Y.Liu,
M.A.Fabian,
and
A.Schepartz
(1997).
Electrostatic mechanism for DNA bending by bZIP proteins.
|
| |
Biochemistry, 36,
10033-10038.
|
|
|
|
|
|
|
D.Porte,
P.Oertel-Buchheit,
M.John,
M.Granger-Schnarr,
and
M.Schnarr
(1997).
DNA binding and transactivation properties of Fos variants with homodimerization capacity.
|
| |
Nucleic Acids Res, 25,
3026-3033.
|
|
|
|
|
|
|
G.Patikoglou,
and
S.K.Burley
(1997).
Eukaryotic transcription factor-DNA complexes.
|
| |
Annu Rev Biophys Biomol Struct, 26,
289-325.
|
|
|
|
|
|
|
H.Wendt,
L.Leder,
H.Härmä,
I.Jelesarov,
A.Baici,
and
H.R.Bosshard
(1997).
Very rapid, ionic strength-dependent association and folding of a heterodimeric leucine zipper.
|
| |
Biochemistry, 36,
204-213.
|
|
|
|
|
|
|
J.K.Strauss-Soukup,
and
L.J.Maher
(1997).
DNA bending by GCN4 mutants bearing cationic residues.
|
| |
Biochemistry, 36,
10026-10032.
|
|
|
|
|
|
|
J.P.Basuyaux,
E.Ferreira,
D.Stéhelin,
and
G.Butticè
(1997).
The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.
|
| |
J Biol Chem, 272,
26188-26195.
|
|
|
|
|
|
|
J.Wu,
M.Sektas,
D.Chen,
and
M.Filutowicz
(1997).
Two forms of replication initiator protein: positive and negative controls.
|
| |
Proc Natl Acad Sci U S A, 94,
13967-13972.
|
|
|
|
|
|
|
K.W.Ng,
P.Ridgway,
D.R.Cohen,
and
D.J.Tremethick
(1997).
The binding of a Fos/Jun heterodimer can completely disrupt the structure of a nucleosome.
|
| |
EMBO J, 16,
2072-2085.
|
|
|
|
|
|
|
L.Fernandes,
C.Rodrigues-Pousada,
and
K.Struhl
(1997).
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions.
|
| |
Mol Cell Biol, 17,
6982-6993.
|
|
|
|
|
|
|
M.D.Temple,
M.J.Cairns,
W.A.Denny,
and
V.Murray
(1997).
Protein-DNA interactions in the human beta-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards.
|
| |
Nucleic Acids Res, 25,
3255-3260.
|
|
|
|
|
|
|
M.G.Oakley,
and
P.S.Kim
(1997).
Protein dissection of the antiparallel coiled coil from Escherichia coli seryl tRNA synthetase.
|
| |
Biochemistry, 36,
2544-2549.
|
|
|
|
|
|
|
M.M.Javadpour,
and
M.D.Barkley
(1997).
Self-assembly of designed antimicrobial peptides in solution and micelles.
|
| |
Biochemistry, 36,
9540-9549.
|
|
|
|
|
|
|
M.R.Conte,
A.N.Lane,
and
G.Bloomberg
(1997).
Solution structure of the ATF-2 recognition site and its interaction with the ATF-2 peptide.
|
| |
Nucleic Acids Res, 25,
3808-3815.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
N.L.Ogihara,
M.S.Weiss,
W.F.Degrado,
and
D.Eisenberg
(1997).
The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies.
|
| |
Protein Sci, 6,
80-88.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
N.Rajaram,
and
T.K.Kerppola
(1997).
DNA bending by Fos-Jun and the orientation of heterodimer binding depend on the sequence of the AP-1 site.
|
| |
EMBO J, 16,
2917-2925.
|
|
|
|
|
|
|
P.J.Ferris,
and
U.W.Goodenough
(1997).
Mating type in Chlamydomonas is specified by mid, the minus-dominance gene.
|
| |
Genetics, 146,
859-869.
|
|
|
|
|
|
|
R.E.Dickerson,
and
T.K.Chiu
(1997).
Helix bending as a factor in protein/DNA recognition.
|
| |
Biopolymers, 44,
361-403.
|
|
|
|
|
|
|
S.J.Metallo,
and
A.Schepartz
(1997).
Certain bZIP peptides bind DNA sequentially as monomers and dimerize on the DNA.
|
| |
Nat Struct Biol, 4,
115-117.
|
|
|
|
|
|
|
S.J.Metallo,
D.N.Paolella,
and
A.Schepartz
(1997).
The role of a basic amino acid cluster in target site selection and non-specific binding of bZIP peptides to DNA.
|
| |
Nucleic Acids Res, 25,
2967-2972.
|
|
|
|
|
|
|
S.Pal,
M.C.Lo,
D.Schmidt,
I.Pelczer,
S.Thurber,
and
S.Walker
(1997).
Skn-1: evidence for a bipartite recognition helix in DNA binding.
|
| |
Proc Natl Acad Sci U S A, 94,
5556-5561.
|
|
|
|
|
|
|
S.Pellegrino,
S.Zhang,
A.Garritsen,
and
W.F.Simonds
(1997).
The coiled-coil region of the G protein beta subunit. Mutational analysis of Ggamma and effector interactions.
|
| |
J Biol Chem, 272,
25360-25366.
|
|
|
|
|
|
|
T.K.Kerppola,
and
T.Curran
(1997).
The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions.
|
| |
EMBO J, 16,
2907-2916.
|
|
|
|
|
|
|
T.K.Kerppola
(1997).
Comparison of DNA bending by Fos-Jun and phased A tracts by multifactorial phasing analysis.
|
| |
Biochemistry, 36,
10872-10884.
|
|
|
|
|
|
|
V.Blank,
and
N.C.Andrews
(1997).
The Maf transcription factors: regulators of differentiation.
|
| |
Trends Biochem Sci, 22,
437-441.
|
|
|
|
|
|
|
W.D.Kohn,
C.T.Mant,
and
R.S.Hodges
(1997).
Alpha-helical protein assembly motifs.
|
| |
J Biol Chem, 272,
2583-2586.
|
|
|
|
|
|
|
X.Zeng,
A.M.Herndon,
and
J.C.Hu
(1997).
Buried asparagines determine the dimerization specificities of leucine zipper mutants.
|
| |
Proc Natl Acad Sci U S A, 94,
3673-3678.
|
|
|
|
|
|
|
X.Zeng,
H.Zhu,
H.A.Lashuel,
and
J.C.Hu
(1997).
Oligomerization properties of GCN4 leucine zipper e and g position mutants.
|
| |
Protein Sci, 6,
2218-2226.
|
|
|
|
|
|
|
A.Sitlani,
and
D.M.Crothers
(1996).
Fos and Jun do not bend the AP-1 recognition site.
|
| |
Proc Natl Acad Sci U S A, 93,
3248-3252.
|
|
|
|
|
|
|
C.Harford,
S.Narindrasorasak,
and
B.Sarkar
(1996).
The designed protein M(II)-Gly-Lys-His-Fos(138-211) specifically cleaves the AP-1 binding site containing DNA.
|
| |
Biochemistry, 35,
4271-4278.
|
|
|
|
|
|
|
D.A.Erlanson,
M.Chytil,
and
G.L.Verdine
(1996).
The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complex.
|
| |
Chem Biol, 3,
981-991.
|
|
|
|
|
|
|
D.Garcia de Viedma,
R.Giraldo,
G.Rivas,
E.Fernández-Tresguerres,
and
R.Diaz-Orejas
(1996).
A leucine zipper motif determines different functions in a DNA replication protein.
|
| |
EMBO J, 15,
925-934.
|
|
|
|
|
|
|
D.Krebs,
B.Dahmani,
M.Monnot,
O.Mauffret,
F.Troalen,
and
S.Fermandjian
(1996).
Dissection of the basic subdomain of the c-Jun oncoprotein: a structural analysis of two peptide fragments by CD, Fourier-transform infrared and NMR.
|
| |
Eur J Biochem, 235,
699-712.
|
|
|
|
|
|
|
F.K.Junius,
S.I.O'Donoghue,
M.Nilges,
A.S.Weiss,
and
G.F.King
(1996).
High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.
|
| |
J Biol Chem, 271,
13663-13667.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.F.King
(1996).
NMR spectroscopy and X-ray crystallography provide complementary information on the structure and dynamics of leucine zippers.
|
| |
Biophys J, 71,
1152-1154.
|
|
|
|
|
|
|
H.Chao,
M.E.Houston,
S.Grothe,
C.M.Kay,
M.O'Connor-McCourt,
R.T.Irvin,
and
R.S.Hodges
(1996).
Kinetic study on the formation of a de novo designed heterodimeric coiled-coil: use of surface plasmon resonance to monitor the association and dissociation of polypeptide chains.
|
| |
Biochemistry, 35,
12175-12185.
|
|
|
|
|
|
|
J.Faix,
M.Steinmetz,
H.Boves,
R.A.Kammerer,
F.Lottspeich,
U.Mintert,
J.Murphy,
A.Stock,
U.Aebi,
and
G.Gerisch
(1996).
Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail.
|
| |
Cell, 86,
631-642.
|
|
|
|
|
|
|
J.L.Kolman,
N.Taylor,
L.Gradoville,
J.Countryman,
and
G.Miller
(1996).
Comparing transcriptional activation and autostimulation by ZEBRA and ZEBRA/c-Fos chimeras.
|
| |
J Virol, 70,
1493-1504.
|
|
|
|
|
|
|
K.H.Heuer,
J.P.Mackay,
P.Podzebenko,
N.P.Bains,
A.S.Weiss,
G.F.King,
and
S.B.Easterbrook-Smith
(1996).
Development of a sensitive peptide-based immunoassay: application to detection of the Jun and Fos oncoproteins.
|
| |
Biochemistry, 35,
9069-9075.
|
|
|
|
|
|
|
L.Gonzalez,
D.N.Woolfson,
and
T.Alber
(1996).
Buried polar residues and structural specificity in the GCN4 leucine zipper.
|
| |
Nat Struct Biol, 3,
1011-1018.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.Vandel,
N.Montreau,
E.Vial,
C.M.Pfarr,
B.Binetruy,
and
M.Castellazzi
(1996).
Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization.
|
| |
Mol Cell Biol, 16,
1881-1888.
|
|
|
|
|
|
|
M.A.Dyer,
R.Naidoo,
R.J.Hayes,
C.J.Larson,
G.L.Verdine,
and
M.H.Baron
(1996).
A DNA-bending protein interacts with an essential upstream regulatory element of the human embryonic beta-like globin gene.
|
| |
Mol Cell Biol, 16,
829-838.
|
|
|
|
|
|
|
M.Chytil,
and
G.L.Verdine
(1996).
The Rel family of eukaryotic transcription factors.
|
| |
Curr Opin Struct Biol, 6,
91.
|
|
|
|
|
|
|
M.John,
R.Leppik,
S.J.Busch,
M.Granger-Schnarr,
and
M.Schnarr
(1996).
DNA binding of Jun and Fos bZip domains: homodimers and heterodimers induce a DNA conformational change in solution.
|
| |
Nucleic Acids Res, 24,
4487-4494.
|
|
|
|
|
|
|
M.L.Martin,
P.M.Lieberman,
and
T.Curran
(1996).
Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
|
| |
Mol Cell Biol, 16,
2110-2118.
|
|
|
|
|
|
|
M.Suckow,
M.Lopata,
A.Seydel,
B.Kisters-Woike,
B.von Wilcken-Bergmann,
and
B.Müller-Hill
(1996).
Mutant bZip-DNA complexes with four quasi-identical protein-DNA interfaces.
|
| |
EMBO J, 15,
598-606.
|
|
|
|
|
|
|
P.J.Hagerman
(1996).
Do basic region-leucine zipper proteins bend their DNA targets ... does it matter?
|
| |
Proc Natl Acad Sci U S A, 93,
9993-9996.
|
|
|
|
|
|
|
R.Fairman,
H.G.Chao,
T.B.Lavoie,
J.J.Villafranca,
G.R.Matsueda,
and
J.Novotny
(1996).
Design of heterotetrameric coiled coils: evidence for increased stabilization by Glu(-)-Lys(+) ion pair interactions.
|
| |
Biochemistry, 35,
2824-2829.
|
|
|
|
|
|
|
R.J.McCormick,
T.Badalian,
and
D.E.Fisher
(1996).
The leucine zipper may induce electrophoretic mobility anomalies without DNA bending.
|
| |
Proc Natl Acad Sci U S A, 93,
14434-14439.
|
|
|
|
|
|
|
R.S.Hodges,
and
R.S.Hodges
(1996).
Boehringer Mannheim award lecture 1995. La conference Boehringer Mannheim 1995. De novo design of alpha-helical proteins: basic research to medical applications.
|
| |
Biochem Cell Biol, 74,
133-154.
|
|
|
|
|
|
|
T.K.Kerppola
(1996).
Fos and Jun bend the AP-1 site: effects of probe geometry on the detection of protein-induced DNA bending.
|
| |
Proc Natl Acad Sci U S A, 93,
10117-10122.
|
|
|
|
|
|
|
T.Sera,
and
P.G.Schultz
(1996).
In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities.
|
| |
Proc Natl Acad Sci U S A, 93,
2920-2925.
|
|
|
|
|
|
|
V.C.Foletta
(1996).
Transcription factor AP-1, and the role of Fra-2.
|
| |
Immunol Cell Biol, 74,
121-133.
|
|
|
|
|
|
|
W.Min,
S.Ghosh,
and
P.Lengyel
(1996).
The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.
|
| |
Mol Cell Biol, 16,
359-368.
|
|
|
|
|
|
|
A.G.Bassuk,
and
J.M.Leiden
(1995).
A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
|
| |
Immunity, 3,
223-237.
|
|
|
|
|
|
|
B.Koldin,
M.Suckow,
A.Seydel,
B.von Wilcken-Bergmann,
and
B.Müller-Hill
(1995).
A comparison of the different DNA binding specificities of the bZip proteins C/EBP and GCN4.
|
| |
Nucleic Acids Res, 23,
4162-4169.
|
|
|
|
|
|
|
D.Krebs,
B.Dahmani,
S.el Antri,
M.Monnot,
O.Convert,
O.Mauffret,
F.Troalen,
and
S.Fermandjian
(1995).
The basic subdomain of the c-Jun oncoprotein. A joint CD, Fourier-transform infrared and NMR study.
|
| |
Eur J Biochem, 231,
370-380.
|
|
|
|
|
|
|
D.Krylov,
M.Olive,
and
C.Vinson
(1995).
Extending dimerization interfaces: the bZIP basic region can form a coiled coil.
|
| |
EMBO J, 14,
5329-5337.
|
|
|
|
|
|
|
D.N.Woolfson,
and
T.Alber
(1995).
Predicting oligomerization states of coiled coils.
|
| |
Protein Sci, 4,
1596-1607.
|
|
|
|
|
|
|
D.Porte,
P.Oertel-Buchheit,
M.Granger-Schnarr,
and
M.Schnarr
(1995).
Fos leucine zipper variants with increased association capacity.
|
| |
J Biol Chem, 270,
22721-22730.
|
|
|
|
|
|
|
| |
Links
