Dbfetch

LOCUS       NM_001043049            7744 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster down syndrome cell adhesion molecule 1,
            transcript variant F (Dscam1), mRNA.
ACCESSION   NM_001043049
VERSION     NM_001043049.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7744)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7744)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7744)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7744)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7744)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7744)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7744)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7744)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7744)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7744)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7744)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7744)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7744)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7744)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 7744)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7744)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 7744)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   24 (bases 1 to 7744)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_033778).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7744
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="2R"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7744
                     /gene="Dscam1"
                     /locus_tag="Dmel_CG17800"
                     /gene_synonym="43Bc; CG17800; CT39257; DmDscam;
                     Dmel\CG17800; Dm_2R:13579; Dm_2R:13612; dscam; dScam;
                     Dscam; DsCam; DScam; DSCAM; Dscam-hv; dscam1; DSCAM1; Dsm;
                     l(2)05518; l(2)43Bc; Neu1; p270"
                     /note="Down syndrome cell adhesion molecule 1"
                     /map="43A4-43B1"
                     /db_xref="FLYBASE:FBgn0033159"
                     /db_xref="GeneID:35652"
     CDS             520..6615
                     /gene="Dscam1"
                     /locus_tag="Dmel_CG17800"
                     /gene_synonym="43Bc; CG17800; CT39257; DmDscam;
                     Dmel\CG17800; Dm_2R:13579; Dm_2R:13612; dscam; dScam;
                     Dscam; DsCam; DScam; DSCAM; Dscam-hv; dscam1; DSCAM1; Dsm;
                     l(2)05518; l(2)43Bc; Neu1; p270"
                     /note="CG17800 gene product from transcript CG17800-RF;
                     CG17800-PF; Dscam1-PF; down syndrome cell adhesion
                     molecule; dscam; down syndrome cell-adhesion molecule;
                     drosophila down syndrome cell adhesion molecule 1; Down's
                     syndrome cell adhesion molecule; lethal(2)43Bc"
                     /codon_start=1
                     /product="down syndrome cell adhesion molecule 1, isoform
                     F"
                     /protein_id="NP_001036514.1"
                     /db_xref="FLYBASE:FBpp0110375"
                     /db_xref="GeneID:35652"
                     /db_xref="FLYBASE:FBgn0033159"
                     /translation="MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKE
                     PTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFR
                     AEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVAQYYEADVNKEHVIRGNSAVIKC
                     LIPSFVADFVEVVSWHTDEEENYFPGAEYDGKYLVLPSGELHIREVGPEDGYKSYQCR
                     TKHRLTGETRLSATKGRLVITEPIASVGPRLLSGNDIKVLQFSASQASTLLCPAQSYP
                     VPVFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESV
                     ETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLR
                     IESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLK
                     CVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCI
                     AKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRA
                     LPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVAPKIASF
                     DFGEEPLNYGEPASVQCTILGGDLPMNVTWLLNNATIDSFHDISFSRIGKRINVLSIE
                     SVSAHHAGFYSCHAQNKAGITAHSARLIVNVPPRWILEPTDKAFAQGSDAKVECKADG
                     FPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGS
                     GLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKN
                     DNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMP
                     YALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQV
                     QKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTW
                     KPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSV
                     VIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGV
                     IKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSV
                     PIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETK
                     TQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDD
                     TFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAG
                     DYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYT
                     LHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKG
                     QKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPD
                     NNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTR
                     IRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVY
                     NQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHST
                     WDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFRE
                     EMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKN
                     SQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEE
                     DQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFN
                     DSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQ
                     QANGAGFTAYDTMAV"
ORIGIN      
        1 agaaccggat ttcagcgcta gtcggcgaat cgcgagagcg tgcgagtatt tgtgtgtgcg
       61 tgtgagcgtt tgttttggga caccgatacg gatacgggta cggatagacg gatatacggc
      121 agcggtacgc gattagcaat ccgccaaccg gttgcagcgg tgctagtgca ccaccctaca
      181 aaaaagtgaa taatagtatg caaagtatct gaaagatagt caagagcaga gcaaagtatc
      241 tgtgtttgtg tgtgccgtgc ttttgtgcgg agtcgccacc cccgtggatt agtggcaccc
      301 tgctgcaaat agcccaccac tctcacaagt gtgtgtgtgt gagtgttaac aattaatcgc
      361 atttaaaaaa caatttggcc agccgcagta acaataacga taattcggac gtgccaaggg
      421 tgcttttcag tggatttttg cgtaaaatcg atagtcagat agacccgctc tctactgcca
      481 acttcacaca acccgctcag cggaaacacg gcatacgaaa tgaatatgcc caacgaacgc
      541 ctcaaatggc taatgctgtt cgcagctgtt gccctcattg cttgtggtag tcagacccta
      601 gctgccaatc ccccagatgc cgaccaaaaa ggacccgtct tcctcaagga acccaccaac
      661 cgcattgact tctccaactc cacgggcgca gagatcgagt gcaaggccag cggcaatccc
      721 atgcccgaga ttatttggat caggagcgac ggtaccgccg tgggtgatgt gcccggattg
      781 cgtcagatct catccgacgg caagctggtc ttccctccat tccgcgccga ggactaccgc
      841 caggaggtcc atgcccaggt gtacgcctgc ctggcccgca accagttcgg atccattatc
      901 tcccgggacg tccatgtgcg agccgtggtt gcccagtact acgaggcgga tgttaacaag
      961 gagcacgtta taagaggcaa ttcggcggtc atcaagtgtc tgattccatc cttcgtggcc
     1021 gatttcgtcg aagtggtgtc ctggcacacc gatgaggagg agaactactt tccgggcgcg
     1081 gaatacgatg gaaagtacct ggtattgccc tctggagagc tgcacatccg tgaggttgga
     1141 cccgaggacg gatacaagag ctaccagtgc cgaaccaaac atcgtctgac cggagaaacc
     1201 cgattaagtg ccacaaaagg acgattggtc atcacagaac ccattgcgag tgtggggccc
     1261 agacttctct ctggtaatga cattaaggtg cttcagttct ctgcgagcca agccagcacc
     1321 ctcttgtgtc cagctcaatc atatccagtg ccagtcttta gatggtacaa gttcatcgaa
     1381 ggaacaaccc gtaaacaagc tgtggtgcta aatgaccgtg tgaagcaggt ctctggtact
     1441 ctcattatta aggacgcagt agtcgaggac tccggaaaat acctgtgcgt ggtgaacaat
     1501 tccgtgggag gcgaaagcgt tgagactgtg cttaccgtca ctgcccccct atccgctaag
     1561 atcgatcctc ccacacagac agttgacttc ggacgccccg ccgtattcac ttgccagtac
     1621 actggaaatc ccatcaagac cgttagctgg atgaaggacg gcaaggctat cggacacagc
     1681 gaacccgtgc tgcgcatcga atccgtgaag aaggaggaca agggcatgta ccagtgcttc
     1741 gtaagaaacg accaggaatc ggcggaggcg agtgctgagc tgaagctcgg aggccgtttc
     1801 gatccccccg tcatccgaca ggccttccag gaagagacca tggaacccgg accaagtgta
     1861 ttcctcaagt gcgtcgccgg cggaaacccc acgcccgaaa tttcctggga actcgacggc
     1921 aagaaaatcg ccaacaacga tcgctatcag gtcggacagt atgtgacggt caacggagat
     1981 gtggtttcct atctgaacat aacctcggtc cacgccaacg atggcggtct ctacaagtgc
     2041 atagccaaga gcaaagtggg cgtggccgaa cactcggcca agttgaatgt atatggactg
     2101 ccctacatcc ggcaaatgga gaagaaggca attgttgctg gagaaaccct gattgtcaca
     2161 tgtcctgtag ctggataccc catcgattcg attgtctggg agcgagataa ccgtgccctg
     2221 cccatcaacc gcaaacagaa ggtcttcccc aacggaacgc tgattatcga gaatgtggaa
     2281 cggaactcag accaagcgac ctacacttgc gttgccaaga atcaggaagg atactctgct
     2341 cgaggatctc tggaagtgca agtcatggtg gctcccaaga tagcgtcctt tgatttcggg
     2401 gaagagcctc tgaactacgg agaacctgcg tcagtacagt gcaccatttt gggtggagac
     2461 ctgcccatga atgtcacctg gttgctgaat aacgccacca ttgatagttt tcatgacatt
     2521 tccttctcgc ggatcgggaa gcggatcaat gtgctctcca ttgagtccgt gtccgctcat
     2581 cacgccggat tctattcgtg tcacgcgcag aacaaggccg gaatcacggc gcactcggcg
     2641 cggctgatcg tgaatgtacc tcccagatgg atcctcgagc ccaccgataa ggccttcgcc
     2701 cagggatccg atgccaaggt tgaatgcaag gctgatggct tccccaaacc ccaagttaca
     2761 tggaagaaag cagttggcga cacccccgga gagtacaagg atctaaagaa gagcgacaac
     2821 atccgcgtgg aagagggcac tctgcatgtc gacaacatcc aaaagaccaa cgagggctac
     2881 tatctgtgcg aggctatcaa tggaataggc tccggcctct cggctgtgat tatgatcagc
     2941 gttcaggccc ctccagagtt cacggagaag ctgcgcaacc agaccgcccg acgaggagaa
     3001 cccgccgtac tccagtgcga ggcgaagggc gagaagccca ttggcatctt gtggaacatg
     3061 aacaacatgc gactggaccc aaagaacgac aatcggtaca ccattcgtga ggagatcctt
     3121 tccaccggag ttatgtccag tctgtcgatc aagcgcaccg agagatccga ctccgcccta
     3181 ttcacctgtg tcgccactaa tgcctttgga tccgatgacg ccagcataaa tatgattgtc
     3241 caggaagttc cggagatgcc atatgctttg aaggtactcg acaaatccgg acgttccgtg
     3301 cagctgagct gggcgcaacc ctacgatggc aactcccctc tggacaggta catcattgag
     3361 tttaagcgtt ctcgtgcctc ctggagcgaa attgatcgcg tcatcgtgcc cggacacacc
     3421 acagaagccc aagtgcagaa gctcagcccc gccaccacct acaacattcg catcgtggcc
     3481 gaaaacgcca tcggcacatc ccaatcctct gaagcggtca ctatcatcac agccgaagaa
     3541 gcaccctccg gcaagcccca gaacatcaag gtagaacccg tgaaccagac caccatgcgc
     3601 gtcacctgga agccaccacc acgcaccgag tggaacggag agatcctggg ctactacgtc
     3661 ggctacaagc tatccaacac taactcgtcc tacgttttcg agaccatcaa cttcatcacc
     3721 gaggagggca aggagcacaa cctggaactg cagaacctgc gcgtgtacac ccagtactcc
     3781 gtggtgatcc aggccttcaa caagatcgga gctggtccac tgagcgaaga ggagaaacaa
     3841 ttcacggccg agggaacgcc cagccagcca cccagtgaca ccgcctgcac caccttaact
     3901 tcgcagacca ttcgcgtcgg atgggtgagc ccacccctgg aatccgccaa cggagtgatc
     3961 aagacctata aggttgtcta tgcccccagt gacgagtggt atgacgagac caagcgacac
     4021 tataagaaga cggcctcctc cgacacagtc ctccatggct taaagaagta caccaactac
     4081 acaatgcagg tcctggccac aacagccgga ggcgatggcg tccgcagcgt tcccatccac
     4141 tgccaaaccg aacccgatgt tcccgaagca cccactgatg taaaggctct tgttatgggt
     4201 aacgccgcta tcctggtatc ctggcgccca ccagcacagc caaacggcat tatcacccag
     4261 tacaccgtgt actccaaggc cgaaggcgct gagactgaga caaagaccca gaaggttccc
     4321 cactaccaga tgagtttcga ggccaccgaa ctggagaaga acaagcccta cgagttctgg
     4381 gtgacagcta gcaccaccat tggcgaaggc cagcagtcta agagcatagt ggccatgccc
     4441 agcgaccagg tgcccgccaa gatcgcctcc ttcgacgaca ccttcactgc caccttcaag
     4501 gaggacgcca agatgccctg cctggccgtt ggagcccccc aacccgagat cacatggaag
     4561 atcaagggcg tcgaattcag tgccaacgat cgcatgcgcg tcctccccga cggatcgctg
     4621 ctgatcaagt cggtaaatcg ccaggatgcc ggagactact cctgccacgc cgagaactcg
     4681 attgctaagg actccatcac gcacaaactg attgttctgg caccaccaca atcgccccac
     4741 gtcaccctct cggcaaccac cactgatgcc ctgactgtaa agttgaagcc ccatgaggga
     4801 gacactgctc ctctgcatgg atacaccctg cactacaagc cagaattcgg agaatgggaa
     4861 acatcggaag tgtctgtcga ctcacagaag cacaacatcg aaggtctctt gtgcggctcc
     4921 cgctatcagg tctatgccac aggattcaat aacattggag ctggcgaagc ttctgacatt
     4981 ttgaacaccc ggaccaaggg acagaagccc aagctgcccg agaaacctcg cttcattgaa
     5041 gtgtcgtcca actcggtgtc cctgcacttc aaggcctgga aagatggagg atgccccatg
     5101 tcgcactttg tggtggagag caagaagcgc gatcaaattg agtggaacca aatttcgaac
     5161 aacgtgaagc ccgataacaa ctacgtggtt ttggacctgg aacccgccac ctggtacaac
     5221 ctccgcatca ctgcccacaa ctcggctggc ttcactgtgg ccgaatacga ctttgccacc
     5281 ttaaccgtta ccggaggcac cattgcgccc ctggacgacg gatccggcca cggcaacgtg
     5341 cacacccgca tccgcctgcc cgcctggatg cccgagtggc tcgatctcaa cttcatggtg
     5401 cccctaattg ccaccgtggt cgtggtggcg gtgggcatct gcgtggtgtg cgtggcccta
     5461 tctcggaggc gagcggacga catgcgcggc ggccaaaagg atgtgtacta cgatgtagtt
     5521 tacaatcaga caatgggacc cggcgccacc ctggacaagc gtcgtccgga cctgcgggat
     5581 gagctcggat acatcgcccc gcccaaccgg aagctgcccc ccgttcccgg atccaactat
     5641 aatacctgtg accggattaa gcgaggccgc ggtggcctcc ggtccaacca ctcgacctgg
     5701 gaccctcgac gcaatcccaa cctgtacgag gagctgaagg ccccgccagt gccgatgcac
     5761 ggcaaccatt acggccacgc ccacggcaat gccgagtgcc actacaggca tccaggcatg
     5821 gaagatgaaa tctgccccta tgccacgttc cacctgctcg gattccgcga ggaaatggac
     5881 cctaccaagg ccatgaactt ccagaccttc ccccaccaga acggacacgc cggcccagtt
     5941 cccggacacg cgggcactat gcttccacca ggacatccag gacacgtgca ctcccgctcc
     6001 ggatcgcaat cgatgcctcg ggccaatcga taccagcgaa agaacagcca gggcggacag
     6061 tcctcaatct acacgccagc tcccgaatac gatgatcccg ccaactgtgc cgaagaggac
     6121 caatatcgtc gatacacccg cgtcaactcg caaggcggta gcctgtactc cggacccgga
     6181 cccgaatacg acgatcccgc caactgcgca cccgaagagg atcagtacgg ctcccagtac
     6241 ggaggaccct atggacagcc ctatgatcac tacggttccc ggggatccat gggacgtcgt
     6301 agcatcggct ctgctcgcaa tcctggcaat ggatcacccg agcctccacc accaccacca
     6361 cgcaaccacg acatgagcaa ctcctcattc aacgactcca aggagagtaa tgagatctca
     6421 gaggcagagt gcgatcgtga ccacggacca cgcggaaact acggagcagt gaagcgatct
     6481 ccacaaccga aagatcagcg caccaccgaa gaaatgcgca aactgataga aagaaacgaa
     6541 accggcccaa aacaactcca actccaacaa gcaaatggcg caggattcac agcctacgat
     6601 actatggcag tgtaatttgt aagcgccctc tgcggcggtg ggcgtggcat tttagcttag
     6661 tgttttaggt gcatgaagtg cgtgggagtt gaatgacact tagagacaca ggacacagat
     6721 acacacagac agatcatcag gacacaagga aagagataga gaaagagagg gagttatata
     6781 ccgaatatac acgtaaaata ttcaactact tcgagtaatt atagcgaagg aatgcaagtt
     6841 tcaagaaaca tatttatatt gtctatgcaa gcagcaaacc aaacttacat aaagtatata
     6901 agtacattca atggataact actataagag agtgctggag acactgaagg aaattactca
     6961 agttattcga gaggaacaga aaacgaaatc tcaagatcaa gatcatactt acgtattcga
     7021 actaattttc aataatgtac tttagtttta agcggtgtct accgaaatat cagagcaaca
     7081 gcaactgaga tggattcttg tgtgtaagag gagatgattc gaaatctgtt tgtgtaaact
     7141 tttgccatct atgccaggag cagaaaactc atcctttgcc tagcctaagt caaagtcata
     7201 atattaactc gtctaattga tatatttagt cgtaacatat gcgtaatatg tatgatttct
     7261 tcctatgcat tttataattc gtatggacag cgcacatttg gagttttgtt tgcgttttgc
     7321 gttgacttgt gatgattgtt aatttacaga gctttgtgag tgagtactta cgattgtgct
     7381 cattactcgc tttgttcttt atttacagac aagtgattgt cctatcttag ttcgccctta
     7441 tttttaattc aaaaatgcgc ttccaacaga acaaatcgaa actgttcaat gcacaaatcg
     7501 cagccacaac aattgaatgt attatacaag atccccagga caccgaaaaa ccaaaacccc
     7561 taacccgaaa cacagataca ctcaagcacg atttattaaa ccaattctga tatagaccgt
     7621 tctgaacatg agttatacgc atttgaagct ttaagagaac ctgaaattgt ttatttcact
     7681 tcatttgatc tatcctaagt tattagttca taagttgcta aatatatgat tttgatttta
     7741 tttt
//