Dbfetch
ID HLA01098; SV 4; standard; DNA; HUM; 4786 BP. XX AC HLA01098; XX SV HLA01098.4 XX DT 03-SEP-1999 (Rel. 1.04.0, Created, Version 1) DT 08-APR-2011 (Rel. 3.04.0, Last Updated, Version 4) XX DE HLA-DOB*01:01:01:01, Human MHC Class II sequence XX KW Human MHC; HLA; Class II; HLA-DOB; Allele; HLA-DOB*01:01:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.57.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX RN [1] RP 1-4786 RX PUBMED; 2998758. RA Tonnelle C, DeMars R, Long EO; RT "DO beta: a new beta chain gene in HLA-D with a distinct regulation of RT expression."; RL EMBO Journal 4:2839-2847(1985). XX RN [2] RP 1-4786 RX PUBMED; 2499532. RA Jonsson AK, Rask L; RT "Human class II DNA and DOB genes display low sequence variability."; RL Immunogenetics 29:411-413(1989). XX RN [3] RP 1-4786 RX PUBMED; 12445321. RA Naruse TK, Kawata H, Inoko H, Isshiki G, Yamano K, Hino M, Tatsumi N; RT "The HLA-DOB gene displays limited polymorphism with only one amino acid RT substitution."; RL Tissue Antigens 59:512-519(2002). XX RN [4] RP 1-4786 RX PUBMED; 15140828. RA Stewart CA, Horton R, Allcock RJ, Ashurst JL, Atrazhev AM, Coggill P, RA Dunham I, Forbes S, Halls K, Howson JM, Humphray SJ, Hunt S, Mungall AJ, RA Osoegawa K, Palmer S, Roberts AN, Rogers J, Sims S, Wang Y, Wilming LG, RA Elliott JF, de Jong PJ, Sawcer S, Todd JA, Trowsdale J, Beck S; RT "Complete MHC haplotype sequencing for common disease gene mapping."; RL Genome Research 14:1176-1187(2004). XX DR EMBL; AB035249; AB035249.1. DR EMBL; AL669918; AL669918.5. DR EMBL; M26040; M26040.1. DR EMBL; X03066; X03066.1. XX FH Key Location/Qualifiers FH FT source 1..4786 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Asian, European, Native American, Undefined" FT /cell_line="45.1" FT /cell_line="LCL721" FT /cell_line="PGF" FT /cell_line="SA" FT /cell_line="SPACH" FT /cell_line="SPL" FT CDS join(348..438,1986..2255,2698..2979,3466..3576,3828..3859, FT 4048..4083) FT /codon_start=1 FT /gene="HLA-DOB" FT /allele="HLA-DOB*01:01:01:01" FT /product="MHC Class II HLA-DOB*01:01:01:01 sequence" FT /translation="MGSGWVPWVVALLVNLTRLDSSMTQGTDSPEDFVIQAKADCYFTN FT GTEKVQFVVRFIFNLEEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQAVDGV FT CRHNYRLGAPFTVGRKVQPEVTVYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQE FT ERAGVMSTGPIRNGDWTFQTVVMLEMTPELGHVYTCLVDHSSLLSPVSVEWRAQSEYSW FT RKMLSGIAAFLLGLIFLLVGIVIQLRAQKGYVRTQMSGNEVSRAVLLPQSC" FT UTR 1..347 FT exon 348..438 FT /number="1" FT intron 439..1985 FT /number="1" FT exon 1986..2255 FT /number="2" FT intron 2256..2697 FT /number="2" FT exon 2698..2979 FT /number="3" FT intron 2980..3465 FT /number="3" FT exon 3466..3576 FT /number="4" FT intron 3577..3827 FT /number="4" FT exon 3828..3859 FT /number="5" FT intron 3860..4047 FT /number="5" FT exon 4048..4083 FT /number="6" FT UTR 4084..4786 SQ Sequence 4786 BP; 1188 A; 1036 C; 1111 G; 1451 T; 0 other; cataataaac agtctgccta gttcttctag ggccccataa tatgtcaaac atatattttt 60 acttcttctc ccagcccatt tttagtatac ctaaattact gtcagtgatt ctgcaggcaa 120 acaatggttg agttgtatga cacaactttg tgaaagtatc ctacccagta cctgatgatg 180 caaaactctt ctatcttgat tggttgtcaa tctgaggagt ttccaatcct ggggaagcca 240 gaaaaacagc gatttatact cttaatgggt actttctgac tgaattttat gagctcattc 300 tgaagaggct gacgatttta ctatctcatt tttttccttt ctccagaatg ggttctgggt 360 gggtcccctg ggtggtggct ctgctagtga atctgacccg actggattcc tccatgactc 420 aaggcacaga ctctccaggt aagaacagag caattgtttt tttccagtgt gtatgcaaga 480 attggcatgg gggagtgatg cctttctttg taagtccagg ccacagacca gactggaagt 540 ggcttttggt ttcaaagaac agtgttcttc cctttggcag aaaggtacgc cttgcctctt 600 tacatgggat ggacttcata taccagagcc acctattcaa ggggtaggga ggcaggaaga 660 gggaaacatt gtgtcttgtt taggatcctt attgtgtgta tcaacctcag tcagtgcctg 720 ggcgtgttga aggccttggc ttgggttcga gcctgctggg agaaacaacc tgcagtaggc 780 tgggtcacag aggcaatctg tgattttttg gtcaggacac ggaaacaaat ctcagttggg 840 gtatatgtgg acaaatgaaa ctggaaacaa aggttgctcc ttctgtcatt tattaagcca 900 ctattatatt gtcagaattg tactaaacag ttttgagaag taagagaagt tgaatagaat 960 acattgtcct tgtcctccgg ctaccaggta caagttactt gtcactgtta tttttctagc 1020 acaggtgaca gaatatgcag ccatgaagca atgtgagatg aaagcacata ttaatgagca 1080 gaaacaggat gtaatgtgct aagaacagaa tcccctttgc atgttagttt cattaaatac 1140 aaaagaggaa caaacctggc caggagagat cattattctc agagaataga aaccgccctg 1200 agtttataat gtccattaaa caatacaact gaaaaaaaaa tcagcacaga tgttaaatga 1260 tgatgaaaaa ttcagatttc ccccctggtt tagactacta gaggaaatag agaagagtat 1320 acatgctgag aaattacagg ctggaacttc atctgaaatt agctactgag tgagggataa 1380 gtggggttca cccaggaagg tcattcttat ggctcagttc agagttggag gaggcttctg 1440 aacttagaaa ggaaagtaaa ttacaaccca acattaatag caattatctt tcaagtcttg 1500 acttagatgc aatgtcttca ggacgtcctt cctgacttac ctacattatt aactccattt 1560 gaatttcctt tttattgtag ttgttgttct taagtgcata ggattggttt aattttaccc 1620 aatgagttca cagcacattg taattattgg cagtagtgca agactctctc gtctcttctc 1680 ttgcctccgt tctcattctc tcccctccct agagaatcca ttctaaacgt gtctggtaag 1740 tctctaagta tgagagtggc ttttagaaat atgtagcatt attgctcttt atgtgttttt 1800 aaaatttaat aaatgtcatt ctctgttgaa tcccattctg tttcttttct cacttgacac 1860 tgtgcttttt gagcatactg aggtcaaagg cctcctctta gatccatgtg gtctgacgta 1920 atttaccagg catgggtttt cccagaggag ggggctggtt catggttttg gttttggttt 1980 tccagaagat tttgtgattc aggcaaaggc tgactgttac ttcaccaacg ggacagaaaa 2040 ggtgcagttt gtggtcagat tcatctttaa cttggaggag tatgtacgtt tcgacagtga 2100 tgtggggatg tttgtggcat tgaccaagct ggggcagcca gatgctgagc agtggaacag 2160 ccggctggat ctcttggaga ggagcagaca ggccgtggat ggggtctgta gacacaacta 2220 caggctgggc gcacccttca ctgtggggag aaaaggtgag ctggaagctg aggtctggcg 2280 gggctcagga atgtccccca tgtgaacctg gccatggctc ttctttctta caagcaattt 2340 tctgctttag gataaatggt tgtctgtgta gatgttctgg ccccagctgt gatatattat 2400 cctcacaagt cagccactgt gatcttggtc tcagaccccc aaggttctca gggacttcga 2460 gggctattgt gccctcaaag agaagcagta attgtgggag tacctcagaa agtctaaatc 2520 ctcctgacag gcattgacat accctgttac tgatcttggg ggctgagact tgcctatact 2580 ttgtgttcac ttgggtgatc tgggaaagag attagacata gtgatagtcc ctaaagaatc 2640 tcctgtccca gcttggtggt tttctttcac ggtgtctcat ttttcctccc ttcctagtgc 2700 aaccagaggt gacagtgtac ccagagagga ccccactcct gcaccagcat aatctgctgc 2760 actgctctgt gacaggcttc tatccagggg atatcaagat caagtggttc ctgaatgggc 2820 aggaggagag agctggggtc atgtccactg gccctatcag gaatggagac tggacctttc 2880 agactgtggt gatgctagaa atgactcctg aacttggaca tgtctacacc tgccttgtcg 2940 atcactccag cctgctgagc cctgtttctg tggagtggag tgagaattag tttctagtac 3000 tctctgggcc tgactcagga ctatactgac tcaatacaga gcctgtgtca cttctgcgtt 3060 tatcttggtc acaacatgaa ttattctttc ccttgatctg ggacagtcac agaaaccaga 3120 gtccttgggt tagggtggga gaaaacatgg cagatatcta tcctcatatc ttccaagaaa 3180 tgaggagatc taatcacctc attatgtgct tccaacccta tgaactggtg tcctctaatt 3240 ctttggtctt agtatttagg aggcattctt atgggctgtg agaatctgta accgatgggg 3300 ggtaactcca tgggtgccaa ctttggtttc gaagaacctt ttctaaattt atttattttt 3360 ctctagctag cattggattt ggtgtctagt acagattctg ggattccaag aaagtgcttt 3420 aaatattggg atatttttac taatttaaag acctgtttcc cataggagct cagtctgaat 3480 attcttggag aaagatgctg agtggcattg cagccttcct acttgggcta atcttccttc 3540 tggtgggaat cgtcatccag ctaagggctc agaaaggtaa tgagcctgtg aggagtgccc 3600 tgccacctgt cccagacctt ccccactccc accttcccta acgtcaatga tctgaggcaa 3660 ggaaagctga ttgtgcctct cagggatcac cgggataatt tttttctgaa gctagaaatg 3720 ggataagcag agagagtgct gaccttgcca gccatttgtt cttccctcgg gataatcata 3780 ttgggtccta attggggcaa tccattcttt tctcgatttc tttccaggat atgtgaggac 3840 gcagatgtct ggtaatgagg taatgtctct ttttccttgt ctttgagtgg cagatcattc 3900 tcccggttct ttggccagag ggagatgaca tgggggtagg gaggagtaag gttgctgctg 3960 tctggatggg actgtcccct gagtctctgg aacggctgtg gggggtggtg aggctgcctc 4020 ctgagacctt catcactgtg cctccaggtc tcaagagctg ttctgctccc tcagtcatgc 4080 taaggtcctc actgaagctt ctctctctgg agcctgaagt agtgatgagt agtctgggcc 4140 ctgggtgagg taaaggacat tcatgaggtc aatgttctgg gaataactct cttccctgat 4200 ccttggagga gcccgaactg attctggagc tctgtgttct gagatcatgc atctcccacc 4260 catctgccct tctcccttct acgtgtacat cattaatccc cattgccaag ggcattgtcc 4320 agaaactccc ctgagacctt actccttcca gccccaaatc atttactttt ctgtggtcca 4380 gccctactcc tataagtcat gatctccaaa gctttctgtc ttccaactgc agtctccaca 4440 gtcttcagaa gacaaatgct caggtagtca ctgtttcctt ttcactgttt ttaaaaacct 4500 tttattgtca aataaaatgg agatacaaaa aatgtacatt ttagtgaatt atttaagaaa 4560 aacccctgta atcaagtcaa ggaacaggac tttgccagct ccagcggaag tctctgtacg 4620 tcaggccaat caaagcctct ccttcccctc gaaagtgacc atatcctgat tttattgtaa 4680 cctctttcat gtctttgtag tctagtcccc caggtatgtg ttcctggacg ccacagctta 4740 gttgtctttt acgtctctca tacttcactg gtttctcccc catcag 4786 //