Dbfetch
ID HLA00167; SV 5; standard; DNA; HUM; 4079 BP. XX AC HLA00167; XX SV HLA00167.5 XX DT 14-NOV-1991 (Rel. 1.00.0, Created, Version 1) DT 20-JAN-2017 (Rel. 3.27.0, Last Updated, Version 5) XX DE HLA-B*15:04:01:01, Human MHC Class I sequence XX KW Human MHC; HLA; Class I; HLA-B; Allele; HLA-B*15:04:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.57.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX RN [1] RP 1-4079 RX PUBMED; 1589035. RA Watkins DI, McAdam SN, Liu X, Strang CR, Milford EL, Levine CG, Garber TL, RA Dogon AL, Lord CI, Ghim SH, Troup GM, Hughes AL, Letvin NL; RT "New recombinant HLA-B alleles in a tribe of South American Amerindians RT indicate rapid evolution of MHC class I loci."; RL Nature 357:329-333(1992). XX RN [2] RP 1-4079 RX PUBMED; 1317015. RA Belich MP, Madrigal JA, Hildebrand WH, Zemmour J, Williams RC, Luz R, RA Petzl-Erler ML, Parham P; RT "Unusual HLA-B alleles in two tribes of Brazilian Indians."; RL Nature 357:326-329(1992). XX RN [3] RP 1-4079 RX PUBMED; 12622774. RA Cox ST, McWhinnie AJ, Robinson J, Marsh SGE, Parham P, Madrigal JA, Little RA AM; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). XX DR EMBL; AJ292970; AJ292970.1. DR EMBL; KC677666; KC677666.1. DR EMBL; KC677667; KC677667.1. DR EMBL; KU319239; KU319239.1. DR EMBL; M84382; M84382.1. XX FH Key Location/Qualifiers FH FT source 1..4079 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Admixed, European, Native American" FT /cell_line="GRC-138" FT /cell_line="GRC-150" FT /cell_line="GRC-187" FT /cell_line="KG" FT /cell_line="MDA0000072" FT /cell_line="MDA0000073" FT CDS join(270..342,472..741,987..1262,1838..2113,2218..2334, FT 2776..2808,2915..2958) FT /codon_start=1 FT /gene="HLA-B" FT /allele="HLA-B*15:04:01:01" FT /product="MHC Class I HLA-B*15:04:01:01 sequence" FT /translation="MRVTAPRTVLLLLSGALALTETWAGSHSMRYFYTAMSRPGRGEPR FT FIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQISKTNTQTYRESLRN FT LRGYYNQSEAGSHTWQTMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTAADTA FT AQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHE FT ATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRY FT TCHVQHEGLPKPLTLRWEPSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRRKSSGGK FT GGSYSQAASSDSAQGSDVSLTA" FT UTR 1..269 FT exon 270..342 FT /number="1" FT intron 343..471 FT /number="1" FT exon 472..741 FT /number="2" FT intron 742..986 FT /number="2" FT exon 987..1262 FT /number="3" FT intron 1263..1837 FT /number="3" FT exon 1838..2113 FT /number="4" FT intron 2114..2217 FT /number="4" FT exon 2218..2334 FT /number="5" FT intron 2335..2775 FT /number="5" FT exon 2776..2808 FT /number="6" FT intron 2809..2914 FT /number="6" FT exon 2915..2958 FT /number="7" FT UTR 2959..4079 SQ Sequence 4079 BP; 763 A; 1147 C; 1237 G; 932 T; 0 other; ccaggtcccg gacggggctc tcagggtctc aggctccgag agccttgtct gcattgggga 60 ggcgcagcgt tggggattcc ccactcccac gagtttcact tcttctccca acctatgtcg 120 ggtccttctt ccaggatact cgtgacgcgt ccccatttcc cactcccatt gggtgtcggg 180 tgtctagaga agccaatcag tgtcgccggg gtcccagttc taaagtcccc acgcacccac 240 ccggactcaa aatctcctca gacgccgaga tgcgggtcac ggcgccccga accgtcctcc 300 tgctgctctc gggagccctg gccctgaccg agacctgggc cggtgagtgc ggggtcggca 360 gggaaatggc ctctgtgggg aggagcgagg ggaccgcagg cgggggcgca ggacccgggg 420 agccgcgccg ggaggagggt cgggcgggtc tcagcccctc ctcgccccca ggctcccact 480 ccatgaggta tttctacacc gccatgtccc ggcccggccg cggggagccc cgcttcatcg 540 cagtgggcta cgtggacgac acccagttcg tgaggttcga cagcgacgcc gcgagtccga 600 ggatggcgcc ccgggcgcca tggatagagc aggaggggcc ggagtattgg gaccgggaga 660 cacagatctc caagaccaac acacagactt accgagagag cctgcggaac ctgcgcggct 720 actacaacca gagcgaggcc ggtgagtgac cccggcctgg ggcgcaggtc acgactcccc 780 atcccccacg tacggcccgg gtcgccccga gtctccgggt ccgagatccg cccccctgag 840 gccgcgggac ccgcccaaac cctcgaccgg cgagagcccc aggcgcgttt acccggtttc 900 attttcagtt gaggccaaaa tccccgcggg ttggtcgggg cggggcgggg ctcgggggac 960 ggggctgacc gcggggcctg ggccagggtc tcacacttgg cagacgatgt atggctgcga 1020 cgtggggccg gacgggcgcc tcctccgcgg gcatgaccag tccgcctacg acggcaagga 1080 ttacatcgcc ctgaacgagg acctgagctc ctggaccgcg gcggacacgg cggctcagat 1140 cacccagcgc aagtgggagg cggcccgtga ggcggagcag tggagagcct acctggaggg 1200 cctgtgcgtg gagtggctcc gcagatacct ggagaacggg aaggagacgc tgcagcgcgc 1260 gggtaccagg ggcagtgggg agccttcccc atctcctata ggtcgccggg gatggcctcc 1320 cacgagaaga ggaggaaaat gggatcagcg ctagaatgtc gccctccctt gaatggagaa 1380 tggcatgagt tttcctgagt ttcctctgag ggccccctct tctctctagg acaattaagg 1440 gatgacgtct ctgaggaaat ggaggggaag acagtcccta ggatagtgat caggggtccc 1500 ctttgacccc tgcagcagcc ttgggaaccg tgacttttcc tctcaggcct tgttctctgc 1560 ctcacactca gtgtgtttgg ggctctgatt ccagcacttc tgagtcactt tacctccact 1620 cagatcagga gcagaagtcc ctgttccccg ctcagagact cgaactttcc aatgaatagg 1680 agattatccc aggtgcctgc gtccaggctg gtgtctgggt tctgtgcccc ttccccaccc 1740 caggtgtcct gtccattctc aggctggtca catgggtggt cctagggtgt cccatgagag 1800 atgcaaagcg cctgaatttt ctgactcttc ccatcagacc ccccaaagac acatgtgacc 1860 caccacccca tctctgacca tgaggccacc ctgaggtgct gggccctggg cttctaccct 1920 gcggagatca cactgacctg gcagcgggat ggcgaggacc aaactcagga caccgagctt 1980 gtggagacca gaccagcagg agatagaacc ttccagaagt gggcagctgt ggtggtgcct 2040 tctggagaag agcagagata cacatgccat gtacagcatg aggggctgcc gaagcccctc 2100 accctgagat ggggtaagga gggggatgag gggtcatatc tgttctcagg gaaagcagga 2160 gcccttctgg agcccttcag cagggtcagg gcccctcatc ttcccctcct ttcccagagc 2220 catcttccca gtccaccatc cccatcgtgg gcattgttgc tggcctggct gtcctagcag 2280 ttgtggtcat cggagctgtg gtcgctactg tgatgtgtag gaggaagagc tcaggtaggg 2340 aaggggtgag gggtggggtc tgggttttct tgtcccactg ggggtttcaa gccccaggta 2400 gaagtgttcc ctgcctcatt actgggaagc agcatccaca caggggctaa cgcagcctgg 2460 gaccctgtgt gccagcactt actcttttgt gcagcacatg tgacaatgaa ggacagatgt 2520 atcgccttga tggttgtggt gttggggtcc tgattccagc attcatgagt caggggaagg 2580 tccctgctaa ggacagacct taggagggca gttggtccag gacccacact tgctttcctc 2640 gtgtttcctg atcctgccct gggtctgtag tcatacttct ggaaattcct tttggttcca 2700 agacgaggag gttcctctaa gatctcatgg tcctgcttcc tcccagtccc ctcacaggac 2760 attttcttcc cacaggtgga aaaggaggga gctactctca ggctgcgtgt aagtggtggg 2820 ggtgggagtg tggaggagct cacccacccc ataattcctc ctgtcccacg tctcctgcgg 2880 gctctgacca ggtcctgttt ttgttctact ccagccagcg acagtgccca gggctctgat 2940 gtgtctctca cagcttgaaa aggtgagatt cttggggtct agagtgggtg gggtggcggg 3000 tctgggggtg ggtggggcag tggggaaagg cctgggtaat ggagattctt tgattgggat 3060 gtttcgcgtg tgtcgtgggc tgttcagagt gtcatcactt accatgacta accagaattt 3120 gttcatgact gttgttttct gtagcctgag acagctgtct tgtgagggac cgagatgcag 3180 gatttcttca cgcctcccct ttgtgacttc aagagcctct ggcatctctt tctgcaaagg 3240 cacctgaatg tgtctgcgtc cctgttagca taatgtgagg aggtggagag acagcccacc 3300 cttgtgtcca ctgtgacccc tgttcccatg ctgatctgtg tttcctcccc agtcatcttt 3360 cttgttccag agaggtgggg ctggatgtct ccatctctgt ctcaacttta tgtgcactga 3420 gctgcaactt cttacttccc tactgaaaat aagaatctga atataaattt gttttctcaa 3480 atatttgcta tgagaggttg atggattaat taaataagtc aattcctgga atttgaaaga 3540 gcaaataaag acctgagaac cttccagaat ctgcatgttc gctgtgctga gtctgttgca 3600 ggtggggtgt ggagaaggct gtggggggcc gagtgtggat ggggcctgtg cccatttggt 3660 gttgagtcca tcatgggctt tatgtggtta gtcgtcagct gggtcacctt cactgctcca 3720 ttgtccttgt cccttcagtg gaaacttgtc cagtgggagc tgtgaccaca gaggctcaca 3780 catcgcccag ggtggcccct gcacacgggg gtctctgtgc attctgagac aaattttcag 3840 agccattcac ctcctgccct gcttctagag ctccttttct gctctgctct cctgccctct 3900 ctccctgccc tggttctagt gatcttggtg ctgaatccaa tcccaactcc tgaatctgta 3960 aagcagagtc taatttagac ttacatttgt ctgtgaaatt ggacccgtca tcaaggactg 4020 ttctttcctg aagagagaac ctgattgtgt gctgcagtgt gctggggcag ggggtgcgg 4079 //