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Vertebrate Genomics Team - Research


A summary of our research interest:

Computational Epigenomics


Our goal is to create automatic, evidence-based functional annotation of the genome through the integration of data high-throughput epigenomics assays and maps of open chromatin. Our models include specific data types including DNase I hypersensitivity, histone modifications, and DNA methylation. The Ensembl Regulatory Build is our first effort at whole genome functional annotation and is one of the major early outcomes and it is now moving into limited projection within Ensembl. In support of this effort we have active collaborations with biology labs at the University of Cambridge and are participating in both the US-based ENCODE (ENCyclopedia Of DNA Elements) project and the European-based HEROIC (High-throughput Epigenetic Regulatory Organisation In Chromatin) project.

Short sequence informatics


Whole genome resequencing, in addition to many of the functional assays described above now use massively-parallel short read sequencing technology. In collaboration the Birney and Bertone Groups at the EBI, we are working to develop methods to analyse, store and process these data.



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