Searching using UniChem Connectivity Search

Our previous searches with UniChem have shown that yohimbine has an identical InChIKey for each entry in the accessed databases. These results do not include other forms of the yohimbine molecule: those with common atomic connectivity but differing stereochemistry or isotopic forms. These alternate forms might be of interest to an analyst’s work, but would not be indentified using the normal UniChem search tool.

Connectivity Search is an expanded version of the standard UniChem tool that allows us to find these related molecules. For example, you might be interested in data on yohimbine hydrochloride, tritiated forms of yohimbine, or even stereochemical variants of yohimbine, such as rauwolscine. You can see in the ChEMBL entries below how different molecules have very subtle differences in structure (Figure 6).