{"id":200,"date":"2020-10-23T11:00:21","date_gmt":"2020-10-23T11:00:21","guid":{"rendered":"http:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/volume-matching-use-case\/"},"modified":"2020-10-23T11:48:36","modified_gmt":"2020-10-23T11:48:36","slug":"volume-matching-use-case","status":"publish","type":"page","link":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/volume-matching-use-case\/","title":{"rendered":"Volume matching use case"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Aligning bacterial ribosomes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The ribosome\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Help:IPA_for_English\"><\/a>is a large and complex molecular machine that serves as the site of biological protein synthesis. The bacterial ribosome is considered to consist of three\u00a0rRNA\u00a0molecules and around 50 proteins. However, it is also the site for a large number of additional proteins that have specific roles in the life cycle of the ribosome. Aligning volume data for ribosomes can help to identify these additional proteins, and any structural changes they may trigger.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tetracycline resistance protein TetO protects the bacterial ribosome from binding the antibiotic tetracycline. It is a translational GTPase with significant similarity to the elongation factor EF-G. We can compare the 9.8&nbsp;\u00c5 volume of a TetO-bound bacterial ribosome (EMD-5562) with a 9.9 \u00c5 volume of a bacterial ribosome with EF-G (and RRF) bound (EMD-1917).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aligning bacterial ribosomes The ribosome\u00a0is a large and complex molecular machine that serves as the site of biological protein synthesis. The bacterial ribosome is considered to consist of three\u00a0rRNA\u00a0molecules and around 50 proteins. However, it is also the site for a large number of additional proteins that have specific roles in the life cycle of&#8230;<\/p>\n","protected":false},"author":30,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-200","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/pages\/200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/comments?post=200"}],"version-history":[{"count":1,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/pages\/200\/revisions"}],"predecessor-version":[{"id":208,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/pages\/200\/revisions\/208"}],"wp:attachment":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/structural-volume-data\/wp-json\/wp\/v2\/media?parent=200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}