Results

ReactomeGSA analysis calculates up and down regulation of genes/proteins based on the submitted dataset. Results of this analysis are presented similar to that of over-representation (explained in this section) with a few additional elements that are described below (Figure 24):

• Up and down regulation of genes/proteins are indicated as arrow heads pointing up or down respectively. If the value is significant (low p-value), there are two arrow heads. 
  • ▲ indicates non-significantly up-regulated genes/proteins
  • ▲▲ indicates significantly up-regulated genes/proteins
  • ▼ indicates non-significantly down-regulated genes/proteins
  • ▼▼ indicates significantly down-regulated genes/proteins
• The Analysis tab in the Details panel contains an additional column indicating if the pathway is up or down regulated, which corresponds to the average value of all the genes/proteins of that pathway.
• The colour scale (right) in the diagram panel that indicates the expression value of genes/proteins is divided into five categories.
  • Significantly up-regulated
  • Non-significantly up-regulated
  • Not found
  • Non-significantly down-regulated
  • Significantly down-regulated