{"id":244,"date":"2020-10-26T15:58:10","date_gmt":"2020-10-26T15:58:10","guid":{"rendered":"http:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/overlay-tools\/"},"modified":"2021-09-29T08:51:37","modified_gmt":"2021-09-29T08:51:37","slug":"overlay-tools","status":"publish","type":"page","link":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/what-can-i-do-with-reactome\/overlay-tools\/","title":{"rendered":"Overlay tools"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Interactors overlay<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In this feature, protein interactions from the interaction database <a href=\"https:\/\/www.ebi.ac.uk\/intact\/home\" target=\"_blank\" rel=\"noreferrer noopener\">IntAct<\/a> are mapped and overlaid on Reactome molecules (Figure 6).<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.6-1024x594.png\" alt=\"\" class=\"wp-image-258\" width=\"712\" height=\"412\" srcset=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.6-1024x594.png 1024w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.6-300x174.png 300w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.6-768x446.png 768w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.6-1536x892.png 1536w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.6-2048x1189.png 2048w\" sizes=\"auto, (max-width: 712px) 100vw, 712px\" \/><figcaption><strong>Figure 6<\/strong> Molecular interactors from <a href=\"https:\/\/www.ebi.ac.uk\/intact\/\" target=\"_blank\" rel=\"noreferrer noopener\">IntAct<\/a> overlaid on Reactome.<\/figcaption><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Expression overlay<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/reactome.org\/PathwayBrowser\/#TOOL=AT\" target=\"_blank\" rel=\"noreferrer noopener\">The Analyse gene list tool<\/a> overlays user provided omics expression data on Reactome molecules (Figure 7).<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.7-1024x539.png\" alt=\"\" class=\"wp-image-260\" width=\"717\" height=\"377\" srcset=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.7-1024x539.png 1024w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.7-300x158.png 300w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.7-768x404.png 768w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.7-1536x808.png 1536w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.7-2048x1077.png 2048w\" sizes=\"auto, (max-width: 717px) 100vw, 717px\" \/><figcaption><strong>Figure 7<\/strong> Example of expression overlay on Reactome pathways.<\/figcaption><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Disease overlay&nbsp;<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In <a href=\"https:\/\/reactome.org\/overlays\/disgenet\" target=\"_blank\" rel=\"noreferrer noopener\">this feature<\/a>, gene-disease associations from <a rel=\"noreferrer noopener\" href=\"https:\/\/www.disgenet.org\/\" target=\"_blank\">DisGeNet<\/a> database are mapped and overlaid on Reactome molecules (Figure 8).<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.8-1024x604.png\" alt=\"\" class=\"wp-image-262\" width=\"719\" height=\"424\" srcset=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.8-1024x604.png 1024w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.8-300x177.png 300w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.8-768x453.png 768w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.8-1536x905.png 1536w, https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-content\/uploads\/sites\/142\/2020\/10\/1.8-2048x1207.png 2048w\" sizes=\"auto, (max-width: 719px) 100vw, 719px\" \/><figcaption><strong>Figure 8<\/strong> Example of <a href=\"https:\/\/www.disgenet.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">DisGeNET<\/a> overlay analysis.<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Interactors overlay In this feature, protein interactions from the interaction database IntAct are mapped and overlaid on Reactome molecules (Figure 6). Expression overlay The Analyse gene list tool overlays user provided omics expression data on Reactome molecules (Figure 7). Disease overlay&nbsp; In this feature, gene-disease associations from DisGeNet database are mapped and overlaid on Reactome&#8230;<\/p>\n","protected":false},"author":30,"featured_media":0,"parent":8,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-244","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/pages\/244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/comments?post=244"}],"version-history":[{"count":7,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/pages\/244\/revisions"}],"predecessor-version":[{"id":354,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/pages\/244\/revisions\/354"}],"up":[{"embeddable":true,"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/reactome-quick-tour\/wp-json\/wp\/v2\/media?parent=244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}