- Course overview
- Search within this course
- Why do we need a pathway database?
- When to use Reactome
- Who is Reactome for?
- Navigating Reactome
- Understanding the Pathway Browser
- Analysing data
- Programmatic access
- Contributing to Reactome
- Summary
- Try it yourself!
- Your feedback
- Get help and support on Reactome
All materials are free cultural works licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, except where further licensing details are provided.
Content and cross-references
Content
Since its creation in 2002, Reactome has been consistently improving its coverage by accumulating data on human reactions and pathways. With a quarterly release cycle, new information flows into Reactome every four months. Some useful metrics of Reactome content are shown in figure 6.
Cross-references
Reactome uses UniProt accession numbers as the primary external reference identifier for peptides. Other primary external references are: ChEBI for small molecules, NCBI taxonomy IDs for species, Gene Ontology (GO) terms for catalytic molecular functions, cellular compartments and biological processes. Reactome cross-references many other relevant sources of biological, chemical and literature information. Reactome’s primary external reference databases are shown in Figure 7.
