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What is PRIDE?

What is proteomics?

Proteomics is the large-scale study of proteomes, the complete sets of proteins present in a cell, tissue or organism. The study of proteomics comprises the applications of technologies for the identification and quantification of the whole proteome. Mass spectrometry is the main approach used in the field. Since proteomics is a well-established discipline, data repositories have emerged to store the data and results coming from different proteomics approaches and technologies.

PRIDE

The PRIDE (PRoteomics IDEntifications) database is a publicly-accessible repository (Figure 1) for mass spectrometry (MS)-based proteomics data, which covers: protein and peptide identifications (including post-translational modifications), protein and peptide expression values, technical and biological metadata and any other supporting evidence (both peak lists and raw data).

Figure 1 Overview of PRIDE submission.

PRIDE is a founding and core member of the ProteomeXchange (PX) consortium (Figure 2), which provides a standard framework for the submission and dissemination of (MS)-based proteomics data to public-domain repositories. Datasets are then submitted to ProteomeXchange via PRIDE and are handled by expert biocurators. PRIDE also integrates proteomics data into other resources such as UniProt (protein sequence information), Ensembl and Expression Atlas (quantitative proteomics experiments).

Figure 2 ProteomeXchange Consortium.

Finally, the PRIDE team is responsible for the development and maintenance of several tools to help you to submit and/or visualise your data before or after data submission: e.g. PRIDE Inspector and the ProteomeXchange submission tool.

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