- Course overview
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- What is Open Targets?
- What is the Open Targets Platform?
- Deep dive into common disease genetics data (GWAS and QTL studies)
- Getting data from the Open Targets Platform
- Summary
- Your feedback
- Get help and support on Open Targets’ informatics tools
- References
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Project SCORE
Project SCORE is a web portal that allows researchers to explore the results of CRISPR-Cas9 whole-genome dropout screens across a diverse collection of human cancer cell models, and to identify dependencies in cancer cells to help guide precision cancer medicines.
The web portal is available at https://score.depmap.sanger.ac.uk/.
This project also developed a scoring framework to prioritise which genes have the potential to make the best cancer therapeutic targets. The framework aggregates and summarises evidence on the expression level of the gene, fitness scores based on the CRISPR data generated within the project, association with a potential therapeutic biomarker, and clinical relevance based on expression in patient tumours.
Introduction to the Cancer Dependency Map (DepMap) project. Video created by Wellcome Sanger Institute. [3]
For further information:
- Read the Project Score publication: Behan et al. (2019)
- Take a look at Open Targets’ blog post about Project SCORE, as well as their interview with lead researcher Fiona Behan
- Read an explainer to understand how Project SCORE fits into the DepMap project’s broader vision