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Why do modelling?

Modelling can help in many different ways to increase our understanding of a particular biological system:

The new insights derived from mathematical modelling can lead to the conceptualisation of new biological questions and hypotheses, as well as the design and execution of experiments to test them. The data generated from these experiments can be fed back into the models, allowing this iterative cycle to continue (Fig 1, Puniya et al, 2024). Refer to a published review for a description of how modelling has contributed to biological advancements, along with an analysis of the challenges faced: Perspectives on computational modeling of biological systems and the significance of the SysMod community.

Figure 1 The Computational Systems Biology iterative cycle, showing how new knowledge arising from the use of mathematical modelling leads to new biological questions and hypotheses which, in turn, generate new experimental data that can be fed back into the computational models (This figure has been reproduced from Puniya et al, 2024).