- Course overview
- Search within this course
- What is CATH database?
- Functional families and structural clusters in CATH
- Search data in CATH
- Summary
- Quiz: Check your learning
- Your feedback
- Get help and support
- References
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Summary
- CATH provides classification of protein domains into structural classes, architectures, folds, and homologous superfamilies.
- An homologous superfamily is subdivided into distinct protein functional families.
- Data in CATH can be searched using text/keyword/superfamily ID, amino acid sequence or 3D structure of the query using https://www.cathdb.info/search/.
- CATH structural classification can be browsed using http://www.cathdb.info/browse/tree.
- A CATH superfamily page provides data on protein domain, visualisation of structure, associated functional families, structure clusters, species diversity, GO and EC annotations.
- Data in CATH is useful to identify/predict protein functions via the functional families (FunFams). The FunFams are also useful in function prediction and in providing information on the evolution of function.
- All the data in CATH are freely available to download from the CATH website.