- Course overview
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- What is InterPro?
- InterPro data
- Searching InterPro
- Visualising InterPro data
- Getting data from InterPro
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- References
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What is InterPro?
Classifying proteins into families and identifying important domains and sites is invaluable for helping biologists to identify distantly related proteins and to predict their functions. A daunting array of resources, each with different strengths and weaknesses, is now available for searching genomes and proteomes with ‘protein signatures’ – diagnostic entities that are used to recognise a particular domain or family.
InterPro combines protein signatures from multiple, diverse databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool for protein sequence classification.
Applications
InterPro is used in the large-scale analysis of whole proteomes, genomes and metagenomes, as well as for the characterisation of individual proteins. Within EMBL-EBI, we use InterPro to help us annotate protein sequences in UniProtKB.